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Progesterone and subsequent polar metabolites are essential for completion of the first meiotic division in amphibian oocytes.

Abstract：

:We find that completion of the first meiotic division in Rana pipiens oocytes requires the sequential action of at least two steroids: progesterone and one or more subsequent polar metabolites of progesterone. Progesterone binding in vitro to oocyte surface receptors increases during the first 4-5h of exposure, followed by internalization of plasma membrane together with membrane-bound progesterone over the next hour. The internalized progesterone is metabolized to highly polar polyhydroxylated steroid(s) prior to nuclear membrane disappearance at 8-9h. Polar steroids alone cannot induce meiosis, but do so in oocytes pretreated with progesterone for 1h. Similarly, the non-metabolizable progestin R5020 cannot induce meiosis but does if oocytes are subsequently exposed to polar steroids. An inhibitor of steroid alpha-reductase (4-MA) prevents both progesterone metabolism and progesterone-induced meiosis. However, meiosis does occur if 4-MA is followed by a polar steroid. Thus, progesterone binding at the oocyte surface initiates a process which requires polar progesterone metabolites for completion of the first meiotic division.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Kostellow AB,Morrill GA

doi

10.1016/j.mce.2008.05.013

subject

Has Abstract

pub_date

2008-09-10 00:00:00

pages

50-6

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(08)00229-3

journal_volume

291

pub_type

杂志文章

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