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Lifestyle, metabolic disorders and male hypogonadism - A one-way ticket?

Abstract：

:Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices, such as dietary habits and sedentarism. Therefore, hypogonadism is part of a pathological triad gathering unhealthy lifestyle, metabolic disease and genetic background. Additionally, hypogonadism harbors the potential to aggravate underlying metabolic disorders, further sustaining the mechanisms leading to disease. To what extent does lifestyle intervention in men suffering from these metabolic disorders can prevent, improve or reverse hypogonadism, is still controversial. Moreover, recent evidence suggests that the metabolic status of the father is related to the risk of inter and transgenerational inheritance of hypogonadism. In this review, we will address the proposed mechanisms of disease, as well as currently available interventions for hypogonadism.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Crisóstomo L,Pereira SC,Monteiro MP,Raposo JF,Oliveira PF,Alves MG

doi

10.1016/j.mce.2020.110945

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

110945

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(20)30245-8

journal_volume

516

pub_type

杂志文章,评审

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