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PTHrP increases pancreatic beta-cell-specific functions in well-differentiated cells.

Abstract：

:Parathyroid hormone-related protein (PTHrP) is reportedly produced in normal islets and insulinomas. PTHrP induces differentiation in some cell-types and growth in others. We examined whether PTHrP production is greater in well-differentiated or growing beta cells and whether PTHrP induces differentiation or growth in beta cells. We used four groups of the well-differentiated mouse beta cell line MIN6 with 17, 25, 31 and 41 passages, and mouse pancreatic islets. With passage, insulin content diminished, whereas the expression of PTHrP, its activating enzyme furin and cell growth gradually increased. PTHrP increased insulin content and mRNA levels more in MIN6-17 cells than in MIN6-41 cells. In contrast, PTHrP increased DNA synthesis more extensively in MIN6-41 cells than in MIN6-17 cells. Dibutyryl cAMP reproduced PTHrP's effect on insulin content and DNA synthesis. We conclude that PTHrP increases insulin expression in well-differentiated beta cells through the cAMP pathway and stimulates growth in growing beta cells.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Sawada Y,Zhang B,Okajima F,Izumi T,Takeuchi T

doi

10.1016/s0303-7207(01)00482-8

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

265-75

issue

2

eissn

0303-7207

issn

1872-8057

pii

S0303720701004828

journal_volume

182

pub_type

杂志文章

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