Molecular endocrinology of female reproductive behavior.

abstract：:Oxytocin (OT) plays an important role in the onset of human labour by stimulating uterine contractions and promoting prostaglandin/inflammatory cytokine synthesis in amnion via oxytocin receptor (OTR) coupling. The OTR-antagonist, Atosiban, is widely used as a tocolytic for the management of acute preterm labour. We f...

journal_title：Molecular and cellular endocrinology

authors： Kim SH,MacIntyre DA,Hanyaloglu AC,Blanks AM,Thornton S,Bennett PR,Terzidou V

更新日期：2016-01-15 00:00:00

abstract：:Previously, we showed that the bio-peptide angiotensin (Ang) II induces interleukin-6 (IL-6) in cultured astrocytes; however, the mechanism(s) involved in this effect were unknown. In the current study, we determined in brainstem and cerebellum astrocytes from the spontaneously hypertensive rat (SHR), the effect of An...

journal_title：Molecular and cellular endocrinology

authors： Gowrisankar YV,Clark MA

更新日期：2016-12-05 00:00:00

abstract：:Exposure of the oestrogen-dominated rat myometrium to either isoproterenol or PGE2 resulted in a rapid but transient accumulation of cyclic AMP, with a progressive loss of responsiveness to the corresponding agonist. Induction of refractoriness was a time- and dose-related phenomenon. In the earliest time, desensitiza...

journal_title：Molecular and cellular endocrinology

authors： Tougui Z,Do Khac L,Harbon S

更新日期：1980-10-01 00:00:00

abstract：:Lipotoxic injury of pancreatic β cells is an important pathological feature in type 2 diabetes mellitus (T2DM). Stimulator of interferon genes (STING) can recognize its own DNA leaked into the cytoplasm from damaged mitochondria or nuclei of the host cell, thus activating its downstream factor interferon regulatory fa...

journal_title：Molecular and cellular endocrinology

authors： Hu HQ,Qiao JT,Liu FQ,Wang JB,Sha S,He Q,Cui C,Song J,Zang N,Wang LS,Sun Z,Chen L,Hou XG

更新日期：2020-12-01 00:00:00

abstract：:Our previous studies have provided evidence for the existence of an intrinsic renin-angiotensin system (RAS) in the rat pancreas, which may play a role in the regulation of pancreatic microcirculation and ductal secretion. Such a pancreatic RAS has recently shown to be activated by chronic hypoxia. The activation of a...

journal_title：Molecular and cellular endocrinology

authors： Leung PS,Chan WP,Nobiling R

更新日期：2000-08-30 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) protects the non-discriminating mineralocorticoid receptor from occupation by glucocorticoids. In man the enzyme is also highly expressed in the placenta where it is thought to also protect the fetus from the high circulating levels of maternal glu...

journal_title：Molecular and cellular endocrinology

authors： Li KX,Smith RE,Ferrari P,Funder JW,Krozowski ZS

更新日期：1996-06-18 00:00:00

abstract：:Granulosa cell (GC) expressed androgen receptors (AR) and intrafollicular androgens are central to fertility. The transactivating domain of the AR contains a polymorphic CAG repeat sequence, which is linked to the transcriptional activity of AR and may influence the GC function. This study aims to evaluate the effects...

journal_title：Molecular and cellular endocrinology

authors： Borgbo T,Macek M Sr,Chrudimska J,Jeppesen JV,Hansen LL,Andersen CY

更新日期：2016-01-05 00:00:00

abstract：OBJECTIVES:The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos. METHODS:The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched bl...

journal_title：Molecular and cellular endocrinology

authors： Sato N,Kawamura K,Fukuda J,Honda Y,Sato T,Tanikawa H,Kodama H,Tanaka T

更新日期：2003-04-28 00:00:00

abstract：:In the presence of retinoic acid (RA), F9 murine teratocarcinoma cells differentiate into cells resembling the extra-embryonic endoderm of the early mouse embryo. Using differential hybridization, we have cloned and characterized six cDNAs corresponding to mRNAs that exhibit reduced expression in F9 cells following RA...

journal_title：Molecular and cellular endocrinology

authors： Faria TN,LaRosa GJ,Wilen E,Liao J,Gudas LJ

更新日期：1998-08-25 00:00:00

abstract：:Melanocortin 4 receptors (MC4R) are mainly expressed in the brain. We previously showed that the anti-inflammatory action of α-melanocyte-stimulating hormone (α-MSH) in rat hypothalamus and in cultured astrocytes involved MC4R activation. However, MC4R mechanisms of action remain undetermined. Since brain-derived neur...

journal_title：Molecular and cellular endocrinology

authors： Caruso C,Carniglia L,Durand D,Gonzalez PV,Scimonelli TN,Lasaga M

更新日期：2012-01-02 00:00:00

abstract：:The concentration of high-affinity estradiol binding sites in the uteri and pituitaries of normal and two dwarf strains of mice was studied. The two dwarf strains are characterized by their total absence of growth hormone or prolactin synthesis and low or absent TSH production. The uteri of the dwarf mice are small bu...

journal_title：Molecular and cellular endocrinology

authors： Sartor P,Slabaugh M,Sakai D,Gorski J

更新日期：1983-01-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) neurons coordinate reproduction. However, whether GnRH neurons directly sense free fatty acids (FFAs) is unknown. We investigated the individual effects of the FFAs docosahexaenoic acid (DHA), palmitate, palmitoleate, and oleate (100 μM each) on Gnrh mRNA expression in the mHypoA-...

journal_title：Molecular and cellular endocrinology

authors： Tran DQ,Ramos EH,Belsham DD

更新日期：2016-05-05 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipogenesis. It is also a central player in energy metabolism, inflammation and immunity. As an important nuclear transcription factor, PPARγ can regulate the expression and function of genes or biological processes directly or indirectly ...

journal_title：Molecular and cellular endocrinology

authors： Su Y,Shen X,Chen J,Isales CM,Zhao J,Shi XM

更新日期：2018-08-15 00:00:00

abstract：:T3 effects on myosin heavy chain gene expression were analysed in muscles undergoing different fates during metamorphosis. Muscle fate was followed by somatic gene transfer of a constitutively expressed luciferase vector. Persistent expression was found in dorsal muscle which is remodelled during metamorphosis whilst ...

journal_title：Molecular and cellular endocrinology

authors： Sachs LM,Lebrun JJ,de Luze A,Kelly PA,Demeneix BA

更新日期：1997-08-08 00:00:00

abstract：:The rapid effects of steroids on spermatozoa have been demonstrated for the first time two decades ago. Progesterone (P), which is present throughout the female genital tract with peaks of levels in the cumulus matrix surrounding the oocyte, stimulates several sperm functions, including hyperactivation and acrosome re...

journal_title：Molecular and cellular endocrinology

authors： Baldi E,Luconi M,Muratori M,Marchiani S,Tamburrino L,Forti G

更新日期：2009-09-24 00:00:00

abstract：:The skin represents a pivotal organ for the human body's vitamin D endocrine system, being both the site of ultraviolet (UV)-B-induced vitamin D synthesis and a target tissue for the pluripotent effects of 1,25(OH)2D3 and other biologically active vitamin D metabolites. As many other steroid hormones, 1,25(OH)2D3 exer...

journal_title：Molecular and cellular endocrinology

authors： Reichrath J,Saternus R,Vogt T

更新日期：2017-09-15 00:00:00

abstract：:The steroid aldosterone plays a major role in the maintenance of total body sodium homeostasis and also contributes to cardiovascular pathophysiology by mediating cardiac hypertrophy and fibrosis. In addition to classical adrenal production of aldosterone, endogenous tissue production of aldosterone has been observed ...

journal_title：Molecular and cellular endocrinology

authors： Rudolph AE,Blasi ER,Delyani JA

更新日期：2000-07-25 00:00:00

abstract：:Inhibin production by cultured granulosa cells from immature diethylstilbestrol (DES)-primed rats was studied in relation to estradiol and progesterone production. The inhibin content in culture media was assayed with a specific radioimmunoassay (RIA) using an antibody to porcine 32 kDa inhibin that recognizes rat inh...

journal_title：Molecular and cellular endocrinology

authors： Suzuki T,Miyamoto K,Hasegawa Y,Abe Y,Ui M,Ibuki Y,Igarashi M

更新日期：1987-12-01 00:00:00

abstract：:We studied the functional properties of hepatic glucagon receptors during rat development. Glucagon binding to liver membranes and isolated hepatocytes was significantly less in foetuses and weaning rats than in adult animals, reflecting changes in the number of receptors rather than any change in receptor affinity fo...

journal_title：Molecular and cellular endocrinology

authors： Blázquez E,Perez Castillo A,de Diego JG

更新日期：1987-02-01 00:00:00

abstract：:The effect of thyroid status on the postnatal development of the two molecular forms of Na+,K+-ATPase, distinguished kinetically on the basis of their ouabain sensitivity, was examined in rat brain. Hypothyroidism induced by PTU from day 1 postnatally significantly reduced the Na+,K+-ATPase activity in cerebellum (22-...

journal_title：Molecular and cellular endocrinology

authors： Atterwill CK,Reid J,Athayde CM

更新日期：1985-05-01 00:00:00

abstract：:Incubation of pituitary GH1 cells with N'-methylnicotinamide, nicotinamide and 3-acetylpyridine which inhibit nuclear ADP-ribosylation and/or the cellular concentration of its substrate NAD+ reduced the amount of nuclear thyroid hormone receptors in a time- and dose-dependent manner without altering the affinity of th...

journal_title：Molecular and cellular endocrinology

authors： Sanchez-Pacheco A,Perez P,Villa A,Pascual A,Aranda A

更新日期：1993-02-01 00:00:00

abstract：:It is well known that ovulation is induced by luteinizing hormone (LH) surge. However, the down-stream factors that mediating LH surge induced ovulation are less clear. The cyclooxygenases (also known as PTGS) as key enzymes for prostaglandins synthesis appear to be important for ovulation in mammals, but their functi...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Liu Y,Li J,Li G,Chen Y,Yin Y,Guo Y,Cheng CH,Liu X,Lin H

更新日期：2017-05-15 00:00:00

abstract：:Mutations in Thyroglobulin (TG) are common genetic causes of congenital hypothyroidism (CH). But the TG mutation spectrum and its frequency in Chinese CH patients have not been investigated. Here we conducted a genetic screening of TG gene in a cohort of 382 Chinese CH patients. We identified 22 rare non-polymorphic v...

journal_title：Molecular and cellular endocrinology

authors： Hu X,Chen R,Fu C,Fan X,Wang J,Qian J,Yi S,Li C,Luo J,Su J,Zhang S,Xie B,Zheng H,Lai Y,Chen Y,Li H,Gu X,Chen S,Shen Y

更新日期：2016-03-05 00:00:00

abstract：:The growth of ZR-75-1 cells, a line of human breast cancer cells in culture, is stimulated by oestradiol and inhibited by anti-oestrogens. Changes in growth rate caused by these agents are accompanied by changes in activity of ornithine decarboxylase, a rate-limiting enzyme for polyamine synthesis. Furthermore, the gr...

journal_title：Molecular and cellular endocrinology

authors： Hoggard N,Green CD

更新日期：1986-06-01 00:00:00

abstract：:With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PCOS-like phenotypes,...

journal_title：Molecular and cellular endocrinology

authors： Abbott DH,Nicol LE,Levine JE,Xu N,Goodarzi MO,Dumesic DA

更新日期：2013-07-05 00:00:00

abstract：:Alternative mRNA splicing diversifies the products encoded by the NCoR and SMRT corepressor loci. There is a programmed alteration in NCoR mRNA splicing during adipocyte differentiation from an NCoRω isoform, which contains three nuclear receptor interaction domains, to an NCoRδ isoform that contains two nuclear recep...

journal_title：Molecular and cellular endocrinology

authors： Snyder CA,Goodson ML,Schroeder AC,Privalsky ML

更新日期：2015-09-15 00:00:00

abstract：:The rate of dissociation of recombinant, purified human estrogen receptor alpha (ERalpha) from a fluorescein-labeled DNA containing the consensus vitellogenin ERE sequence (F-vitERE) was determined in real time using fluorescence anisotropy. The complex of estradiol-occupied ERalpha with F-vitERE had an apparent disso...

journal_title：Molecular and cellular endocrinology

authors： Szatkowski Ozers M,Hill JJ,Ervin K,Royer CA,Gorski J

更新日期：2001-04-25 00:00:00

abstract：:The canonical renin-angiotensin system (RAS) involves the initial action of renin to cleave angiotensinogen to angiotensin I (ANG I), which is then converted to ANG II by the angiotensin converting enzyme (ACE). ANG II plays a critical role in numerous physiological functions, and RAS overactivity underlies many condi...

journal_title：Molecular and cellular endocrinology

authors： Henriksen EJ,Prasannarong M

更新日期：2013-09-25 00:00:00

abstract：:The electrophoretic mobility and surface charge of thymocytes was reduced on incubation of the cells with growth hormone in vitro. All cells in thymus were not found to be sensitive to the hormone. The proportion of cells whose surface charge was altered by the hormone was 65% in the thymocytes from 5-week-old rats. T...

journal_title：Molecular and cellular endocrinology

authors： Hanjan SN,Talwar GP

更新日期：1975-09-01 00:00:00

abstract：:The crucial effects of androgens on the male skeleton are at least partly mediated via the androgen receptor (AR). In addition to hormone binding, the AR activity is regulated by post-translational modifications, including SUMOylation. SUMOylation is a reversible modification in which Small Ubiquitin-related MOdifier ...

journal_title：Molecular and cellular endocrinology

authors： Wu J,Movérare-Skrtic S,Zhang FP,Koskela A,Tuukkanen J,Palvimo JJ,Sipilä P,Poutanen M,Ohlsson C

更新日期：2019-01-05 00:00:00