Abstract：
:The electrophoretic mobility and surface charge of thymocytes was reduced on incubation of the cells with growth hormone in vitro. All cells in thymus were not found to be sensitive to the hormone. The proportion of cells whose surface charge was altered by the hormone was 65% in the thymocytes from 5-week-old rats. The subpopulation of hormone-sensitive cells was reduced to 19% of the total teased-out thymocytes in 1-year-old rats and was below the level of detection in thymocytes derived from 11/2-year-old rats. Analytical studies showed that the alteration in the surface charge of the hormone-sensitive subpopulation was nearly of the same order in thymocytes derived from 5-week and 1-year-old rats, suggesting that the binding capacity of the cells for the hormone was presumably similar at the two ages. On the other hand the quantitative preponderance of the subpopulation of cells sensitive to growth hormone diminishes with age, reaching insignificant levels at 11/2 years.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Hanjan SN,Talwar GPdoi
10.1016/0303-7207(75)90044-1keywords:
subject
Has Abstractpub_date
1975-09-01 00:00:00pages
185-201issue
3eissn
0303-7207issn
1872-8057journal_volume
3pub_type
杂志文章abstract：:The protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu) induced the release of both luteinizing hormone (LH) and growth hormone (GH) from proestrous rat anterior pituitary pieces in vitro. Phorbol 12,13-dibutyrate-induced LH, but not GH release was readily inhibited by the phospholipase A2 (PLA2) inhibit...
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
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journal_title：Molecular and cellular endocrinology
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journal_title：Molecular and cellular endocrinology
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2018-05-15 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/j.mce.2017.06.019
更新日期：2017-10-15 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
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更新日期：2000-03-30 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
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更新日期：2006-02-26 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
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更新日期：1990-01-02 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/0303-7207(92)90094-m
更新日期：1992-12-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
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更新日期：1987-04-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/0303-7207(89)90213-x
更新日期：1989-12-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
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更新日期：1998-07-25 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/0303-7207(84)90145-x
更新日期：1984-11-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/j.mce.2015.02.006
更新日期：2015-04-15 00:00:00
abstract：:Urine based gonadotropin assays provide a practical means of analyzing hormone secretion patterns. While research protocols have revealed pulsatile patterns of gonadotropins such as LH in the blood, these assays are of limited clinical use since daily venipuncture sampling is not feasible outside of a research environ...
journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/j.mce.2006.02.020
更新日期：2007-01-02 00:00:00
