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Phytosteroids beyond estrogens: Regulators of reproductive and endocrine function in natural products.

Abstract：

:Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids - chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations. An interesting example, compound A (4-[1-chloro-2-(methylamino)ethyl]phenyl acetate hydrochloride (1:1)) is a promising selective glucocorticoid receptor modulator (SGRM) based on a phytosteroid isolated from Salsola tuberculatiformis Botschantzev. Given that $6.9 billion of herbal supplements are sold each year, is clear that further identification and characterization of phytosteroids is needed to ensure the safe and effective use of botanical supplements.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Dean M,Murphy BT,Burdette JE

doi

10.1016/j.mce.2016.12.013

subject

Has Abstract

pub_date

2017-02-15 00:00:00

pages

98-105

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(16)30519-6

journal_volume

442

pub_type

杂志文章,评审

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