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Impairment of learning and memory performances induced by BPA: Evidences from the literature of a MoA mediated through an ED.

Abstract：

:Many rodent studies and a few non-human primate data report impairments of spatial and non-spatial memory induced by exposure to bisphenol A (BPA), which are associated with neural modifications, particularly in processes involved in synaptic plasticity. BPA-induced alterations involve disruption of the estrogenic pathway as established by reversal of BPA-induced effects with estrogenic receptor antagonist or by interference of BPA with administered estradiol in ovariectomized animals. Sex differences in hormonal impregnation during critical periods of development and their influence on maturation of learning and memory processes may explain the sexual dimorphism observed in BPA-induced effects in some studies. Altogether, these data highly support the plausibility that alteration of learning and memory and synaptic plasticity by BPA is essentially mediated by disturbance of the estrogenic pathways. As memory function in humans involves similar signaling pathways, this mode of action of BPA has the potential to alter human cognitive abilities.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Mhaouty-Kodja S,Belzunces LP,Canivenc MC,Schroeder H,Chevrier C,Pasquier E

doi

10.1016/j.mce.2018.03.017

subject

Has Abstract

pub_date

2018-11-05 00:00:00

pages

54-73

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(18)30109-6

journal_volume

475

pub_type

杂志文章,评审

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