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Vitamin D and the brain: Genomic and non-genomic actions.

Abstract：

:1,25(OH)2D3 (vitamin D) is well-recognized as a neurosteroid that modulates multiple brain functions. A growing body of evidence indicates that vitamin D plays a pivotal role in brain development, neurotransmission, neuroprotection and immunomodulation. However, the precise molecular mechanisms by which vitamin D exerts these functions in the brain are still unclear. Vitamin D signalling occurs via the vitamin D receptor (VDR), a zinc-finger protein in the nuclear receptor superfamily. Like other nuclear steroids, vitamin D has both genomic and non-genomic actions. The transcriptional activity of vitamin D occurs via the nuclear VDR. Its faster, non-genomic actions can occur when the VDR is distributed outside the nucleus. The VDR is present in the developing and adult brain where it mediates the effects of vitamin D on brain development and function. The purpose of this review is to summarise the in vitro and in vivo work that has been conducted to characterise the genomic and non-genomic actions of vitamin D in the brain. Additionally we link these processes to functional neurochemical and behavioural outcomes. Elucidation of the precise molecular mechanisms underpinning vitamin D signalling in the brain may prove useful in understanding the role this steroid plays in brain ontogeny and function.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Cui X,Gooch H,Petty A,McGrath JJ,Eyles D

doi

10.1016/j.mce.2017.05.035

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

131-143

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(17)30304-0

journal_volume

453

pub_type

杂志文章,评审

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