Tyrosine hydroxylase induction in the young rat: control by thyroid hormones.

abstract：:Cell-cell interactions are crucial role for the proper functioning of endocrine glands. We recently demonstrated that interactions of chromaffin and cortical cells are important for adrenocortical steroidogenesis. However, the molecular mechanisms have not been elucidated and it is unclear if this involves acute and/o...

journal_title：Molecular and cellular endocrinology

authors： Haidan A,Bornstein SR,Liu Z,Walsh LP,Stocco DM,Ehrhart-Bornstein M

更新日期：2000-07-25 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) is a persistent pollutant worldwide and even found in human cord blood and breast milk. Some animal studies have reported that PFOA causes developmental toxicity such as fetal weight loss, but the mechanism is still unclear. This study focused on developmental toxicity of PFOA, particular...

journal_title：Molecular and cellular endocrinology

authors： Suh CH,Cho NK,Lee CK,Lee CH,Kim DH,Kim JH,Son BC,Lee JT

更新日期：2011-04-30 00:00:00

abstract：:FOXL2 is a gene encoding a forkhead transcription factor. Its mutations or misregulation have been shown to cause the blepharophimosis-ptosis-epicanthus inversus (BPES) syndrome and more recently have been associated with the development of Ovarian Granulosa Cell Tumors (OGCT). BPES is a genetic disorder involving mil...

journal_title：Molecular and cellular endocrinology

authors： Caburet S,Georges A,L'Hôte D,Todeschini AL,Benayoun BA,Veitia RA

更新日期：2012-06-05 00:00:00

abstract：:In a series of in vivo and in vitro experiments, the concept has been established that breast cancer cells that express LH/CG or LHRH receptors can be targeted and destroyed by constructs consisting of a lytic peptide moiety and a 15-amino acid segment of the beta-chain of CG or by an LHRH lytic peptide conjugate. Dat...

journal_title：Molecular and cellular endocrinology

authors： Hansel W,Enright F,Leuschner C

更新日期：2007-01-02 00:00:00

abstract：:The juvenoid, methyl farnesoate (MF), is synthesized in the mandibular organs (MOs) of crustaceans, under the control of mandibular organ-inhibiting hormone (MO-IH). Using an in vitro assay to measure synthesis of MF by MOs, the effect of a variety of agents that affect signal transduction pathways was investigated. O...

journal_title：Molecular and cellular endocrinology

authors： Wainwright G,Webster SG,Rees HH

更新日期：1999-08-20 00:00:00

abstract：:Genomewide association studies (GWAS) have indicated that SNPs on a chromosome 16 locus encompassing FTO, as well as IRX3, 5, 6, FTM and FTL are robustly associated with human obesity. GWAS, however, are by nature gene agnostic, and SNPs reaching the appropriate statistical threshold for a given phenotype can appear a...

journal_title：Molecular and cellular endocrinology

authors： Yeo GS

更新日期：2014-11-01 00:00:00

abstract：:Four abundant cDNA clones have been isolated from a rat epididymal cDNA library. Northern blot analysis has shown that these clones partially encode 4.5 kb, 2.8 kb, 1.2 kb and 0.85 kb mRNAs and that their expression is not detectable in total RNA preparations from heart, kidney, liver or testis. Fourteen days after ca...

journal_title：Molecular and cellular endocrinology

authors： Walker JE,Jones R,Moore A,Hamilton DW,Hall L

更新日期：1990-11-12 00:00:00

abstract：:An enzyme system capable of monodeiodinating T4 to T3 and to rT3 in a microsomal fraction of normal human thyroid tissue is characterized. The pH optimum for 5'-monodeiodination of T4 to T3 was around 7.0 The Km (apparent) for the conversion of T4 to T3 was 5.7 mumoles/l. PTU, ipodate and rT3 inhibited T4 deiodination...

journal_title：Molecular and cellular endocrinology

authors： Boye N,Laurberg P

更新日期：1984-10-01 00:00:00

abstract：:The origin of completely novel proteins is a significant question in evolution. The luteinizing hormone (LHB)/chorionic gonadotropin (CGB) gene cluster in humans contains a candidate example of this process. Two genes in this cluster (CGB1 and CGB2) exhibit nucleotide sequence similarity with the other LHB/CGB genes, ...

journal_title：Molecular and cellular endocrinology

authors： Hallast P,Rull K,Laan M

更新日期：2007-01-02 00:00:00

abstract：:Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS completely disrupts the circulating IGF system. Autocrine/paracrine action of local produced IGF-I could explain the mild effect on grow...

journal_title：Molecular and cellular endocrinology

authors： Domené S,Domené HM

更新日期：2020-12-01 00:00:00

abstract：:C-fos promoter activity was examined in FRTL5 rat thyroid cells transiently transfected with a chimeric gene containing the c-fos promoter region linked upstream of the receptor gene chloroamphenicol acetyl transferase (CAT). Thyroid-stimulating hormone (TSH) stimulation of transfected cells increased CAT activity 2- ...

journal_title：Molecular and cellular endocrinology

authors： Damante G,Rapoport B

更新日期：1988-08-01 00:00:00

abstract：:The detergent-soluble extract of rat ovary plasma membranes contained a Gs protein of about 100 kDa as shown by its elution behavior on a Bio Gel A-1.5m column. However, the cell membranes exposed to hCG (37 degrees C, 15 min) contained in addition a higher molecular weight Gs protein complex of 300 kDa comprised of h...

journal_title：Molecular and cellular endocrinology

authors： Seth PK,Bahl OP

更新日期：1991-09-01 00:00:00

abstract：:Central leptin action requires PI3K activity to modulate glucose homeostasis and peripheral metabolism. However, the mechanism behind this phenomenon is not clearly understood. We hypothesize that hypothalamic PI3K activity is important for the modulation of the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxyla...

journal_title：Molecular and cellular endocrinology

authors： Roman EA,Reis D,Romanatto T,Maimoni D,Ferreira EA,Santos GA,Torsoni AS,Velloso LA,Torsoni MA

更新日期：2010-01-15 00:00:00

abstract：:In light of current discussions on multiple forms of inhibin, it was thought of interest to ascertain the identity of the postulated 'iso-hormones' of bull seminal plasma inhibin (Chari et al., 1978). By subjecting the biologically active fraction, obtained by Sephadex G-100 gel filtration of bull seminal plasma aceto...

journal_title：Molecular and cellular endocrinology

authors： Mohapatra SK,Duraiswami S,Chari S

更新日期：1985-07-01 00:00:00

abstract：:Over the last 20 years, aromatase inhibitors have been developed to become a highly effective treatment strategy for treatment of hormone receptor positive breast cancer. Despite their success, poor response and resistance limit the effectiveness of these agents in up to 50% of patients. In recent years, studies using...

journal_title：Molecular and cellular endocrinology

authors： Dunbier AK,Martin LA,Dowsett M

更新日期：2011-07-04 00:00:00

abstract：:Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism (CH), a relatively frequent endocrine disease in newborns (1 in 3000-4000 live births). TD is a defect in the organogenesis of the gland resulting in hypoplastic, ectopic or absent-thyroid gland. TD is usually sporadic but mutations in trans...

journal_title：Molecular and cellular endocrinology

authors： Montanelli L,Tonacchera M

更新日期：2010-06-30 00:00:00

abstract：:During normal early pregnancy circulating monocytes are recruited to the maternal-placental interface where they differentiate to macrophages expressing different functional phenotypes for the maintenance of tissue homeostasis. Pregnancy in the nonobese diabetic (NOD) mouse model presents some pathological features in...

journal_title：Molecular and cellular endocrinology

authors： Larocca L,Hauk V,Calafat M,Roca V,Fraccaroli L,Franchi A,Ramhorst R,Leirós CP

更新日期：2011-02-20 00:00:00

abstract：:We previously reported that testicular zinc finger protein (TZF) is a corepressor for androgen receptor (AR). The present study demonstrated that a central portion (amino acids 512-663) of TZF, TZF(512-663), is responsible for both binding to AR and repressing the transactivation. TZF recruited endogenous histone deac...

journal_title：Molecular and cellular endocrinology

authors： Tao RH,Kawate H,Wu Y,Ohnaka K,Ishizuka M,Inoue A,Hagiwara H,Takayanagi R

更新日期：2006-03-09 00:00:00

abstract：:To elucidate the cellular origin of interleukin-1 (IL-1) in the mammalian testis, we assayed IL-1 activity in culture media of Sertoli cells collected from rats at 20, 35 and 45 days of age as well as in culture media of interstitial, peritubular and germ cells from adult rats. IL-1 was detected in Sertoli cell cultur...

journal_title：Molecular and cellular endocrinology

authors： Gérard N,Syed V,Bardin W,Genetet N,Jégou B

更新日期：1991-11-01 00:00:00

abstract：:The age-related evolution of the in vitro effects of a gonadotropin releasing hormone agonist ([D-Trp6]-GnRH) on the secretion of testosterone by the testis, cultured during 3 days on a Millipore filter floating on M199 medium, was studied during the perinatal period in the rat. The basal and luteinizing hormone (LH)-...

journal_title：Molecular and cellular endocrinology

authors： Habert R,Devif I,Gangnerau MN,Lecerf L

更新日期：1991-12-01 00:00:00

abstract：:In clinical trials of heart failure, spironolactone, an antagonist of the mineralocorticoid receptor (MR), reduced mortality rates by unknown mechanisms. We hypothesized that spironolactone functions by upregulating expression of certain cardiovascular genes. An RNA differential display technique was used to identify ...

journal_title：Molecular and cellular endocrinology

authors： Chun TY,Bloem L,Pratt JH

更新日期：2002-08-30 00:00:00

abstract：:Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor linked with sexual precocity. However, its action and underlying mechanisms on male sexual maturation is unclear. In the present study, we used a unique in vivo ethane dimethane sulfonate (EDS)-induced Leydig cell regeneration mo...

journal_title：Molecular and cellular endocrinology

authors： Chen L,Zhao Y,Li L,Xie L,Chen X,Liu J,Li X,Jin L,Li X,Ge RS

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND/PURPOSE:It remains unclear what role curcumin plays in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis, since some researchers found that curcumin has the ability to inhibit osteoclastogenesis. While others have considered it as an autophagy activator. This study aimed to determine th...

journal_title：Molecular and cellular endocrinology

authors： Ke D,Wang Y,Yu Y,Wang Y,Zheng W,Fu X,Han J,Zhang G,Xu J

更新日期：2020-01-15 00:00:00

abstract：:Inhibitor-1 following phosphorylation by protein kinase A inhibits phosphoprotein phosphatase-1. We have found that in the rat heart inhibitor-1 is present only in the cytosolic fraction and that its phosphorylation in ventricular slices was increased by isoproterenol but not by isoproterenol and propranolol together....

journal_title：Molecular and cellular endocrinology

authors： Iyer RB,Koritz SB,Kirchberger MA

更新日期：1988-01-01 00:00:00

abstract：:Valproic acid (VPA) has been shown to increase the reprogramming efficiency of induced pluripotent stem cells (iPSC) from somatic cells, but the mechanism by which VPA enhances iPSC induction has not been defined. Here we demonstrated that VPA directly activated Oct4 promoter activity through activation of the PI3K/Ak...

journal_title：Molecular and cellular endocrinology

authors： Teng HF,Li PN,Hou DR,Liu SW,Lin CT,Loo MR,Kao CH,Lin KH,Chen SL

更新日期：2014-03-05 00:00:00

abstract：:The aims of the study were to characterize leptin and it is receptor (LEPR) proteins immunoexpression in ovine ovaries and to evaluate the effects of leptin on development of secondary follicles cultured in vitro. The ovaries were collected and fixed for immunohistochemical analysis. Additional pairs of ovaries were c...

journal_title：Molecular and cellular endocrinology

authors： Macedo TJS,Santos JMS,Bezerra MÉS,Menezes VG,Gouveia BB,Barbosa LMR,Lins TLBG,Monte APO,Barberino RS,Batista AM,Barros VRP,Wischral A,Queiroz MAA,Araújo GGL,Matos MHT

更新日期：2019-09-15 00:00:00

abstract：:The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the o...

journal_title：Molecular and cellular endocrinology

authors： Spiga F,Lightman SL

更新日期：2015-06-15 00:00:00

abstract：:Hypothalamic dysfunction is a common feature of experimental obesity. Studies have identified at least three mechanisms involved in the development of hypothalamic neuronal defects in diet-induced obesity: i, inflammation; ii, endoplasmic reticulum stress; and iii, mitochondrial abnormalities. However, which of these ...

journal_title：Molecular and cellular endocrinology

authors： Carraro RS,Souza GF,Solon C,Razolli DS,Chausse B,Barbizan R,Victorio SC,Velloso LA

更新日期：2018-01-15 00:00:00

abstract：:Polymerase chain reaction (PCR) amplification of nt 4502 to nt 5184 of the thyroglobulin (Tg) mRNA from several patients, with or without elevated serum thyrotropin (TSH), showed a predominant fragment of the expected size (683 bp) and a minor fragment of 512 bp. The sequence of this minor fragment revealed that 171 b...

journal_title：Molecular and cellular endocrinology

authors： Targovnik HM,Cochaux P,Corach D,Vassart G

更新日期：1992-03-01 00:00:00

abstract：:Signaling pathways initiated by transforming growth factor-β (TGF-β) and insulin-like growth factors (IGFs) are important in osteosarcoma cell growth. We have investigated a role for endogenous IGF binding protein-3 (IGFBP-3) in mediating cross-talk between TGF-β receptor and type I IGF receptor (IGF1R) signaling path...

journal_title：Molecular and cellular endocrinology

authors： Schedlich LJ,Yenson VM,Baxter RC

更新日期：2013-09-05 00:00:00