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MAP kinase phosphatase 3 inhibits brown adipocyte differentiation via regulation of Erk phosphorylation.

Abstract：

:Brown fat has been highlight as a new therapeutic target for treatment of obesity and diabetes. However, molecular mechanism underlying brown adipogenesis are not fully understood. Here, we identified that MAP kinase phosphatase 3 (MKP3) has a novel role as regulator of brown adipocyte differentiation. The expression of MKP3 was significantly decreased during the early stage(s) of brown adipocyte differentiation in HIB-1B cells and primary cells. Ectopic expression of MKP3 led to reduced brown adipocyte differentiation, whereas depletion of MKP3 significantly enhanced the differentiation of primary brown preadipocytes. Consistently, we found an increased brown adipocyte differentiation in MKP3-null MEF cells. These inhibitory effects of MKP3 could be resulted via the temporal regulation of Erk activation. In recent, it was reported that MKP3 deficient mice are resistant to diet-induced obesity, and display enhanced energy expenditure. Taken together, we suggest that MKP3 could be an important factor in the regulation of brown adipocyte differentiation.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Kim WK,Oh KJ,Choi HR,Park A,Han BS,Chi SW,Kim SJ,Bae KH,Lee SC

doi

10.1016/j.mce.2015.08.023

subject

Has Abstract

pub_date

2015-11-15 00:00:00

pages

70-6

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(15)30063-0

journal_volume

416

pub_type

杂志文章

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