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Nutrition modulation of human aging: The calorie restriction paradigm.

Abstract：

:Globally, the aging population is growing rapidly, creating an urgent need to attenuate age-related health conditions, including metabolic disease and disability. A promising strategy for healthy aging based on consistently positive results from studies with a variety of species, including non-human primates (NHP), is calorie restriction (CR), or the restriction of energy intake while maintaining intake of essential nutrients. The burgeoning evidence for this approach in humans is reviewed and the major study to date to address this question, CALERIE (Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy), is described. CALERIE findings indicate the feasibility of CR in non-obese humans, confirm observations in NHP, and are consistent with improvements in disease risk reduction and potential anti-aging effects. Finally, the mechanisms of CR in humans are reviewed which sums up the fact that evolutionarily conserved mechanisms mediate the anti-aging effects of CR. Overall, the prospect for further research in both NHP and humans is highly encouraging.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Das SK,Balasubramanian P,Weerasekara YK

doi

10.1016/j.mce.2017.04.011

subject

Has Abstract

pub_date

2017-11-05 00:00:00

pages

148-157

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(17)30224-1

journal_volume

455

pub_type

杂志文章,评审

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