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Regulation of the activity of Sp1-related transcription factors.

Abstract：

:The initiation of transcription is accomplished via interactions of many different proteins with common and gene-specific regulatory motifs. Clearly, sequence-specific transcription factors play a crucial role in the specificity of transcription initiation. A group of sequence-specific DNA-binding proteins, related to the transcription factor Sp1, has been implicated in the regulation of many different genes, since binding sites for these transcription factors (GC/GT boxes) are a recurrent motif in regulatory sequences such as promoters, enhancers and CpG islands of these genes. The simultaneous occurrence of several homologous GC/GT box-binding factors precludes a straightforward deduction of their role in transcriptional regulation. In this review, we focus on the connection between functional specificity and biochemical properties including glycosylation, phosphorylation and acetylation of Sp1-related factors.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Bouwman P,Philipsen S

doi

10.1016/s0303-7207(02)00221-6

keywords:

subject

Has Abstract

pub_date

2002-09-30 00:00:00

pages

27-38

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303720702002216

journal_volume

195

pub_type

杂志文章,评审

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