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The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.

Abstract：

:The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypothyroidism, consequent to a reduced gland size and a deranged differentiation. These results demonstrate that Pax8 is also an essential player in controlling survival and differentiation of adult thyroid follicular cells.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Marotta P,Amendola E,Scarfò M,De Luca P,Zoppoli P,Amoresano A,De Felice M,Di Lauro R

doi

10.1016/j.mce.2014.08.004

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

26-36

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(14)00238-X

journal_volume

396

pub_type

杂志文章

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