Interleukin-1 is a potent growth factor for immature rat sertoli cells.

abstract：:Estrogen-related receptor alpha (ERRalpha) modulates estrogen receptor (ER)-mediated activity and is participating in the energy homeostasis by regulation of downstream target genes. The ERRalpha gene itself is proposed to be regulated by peroxisome proliferator-activated receptor gamma coactivator (PGC-1alpha) throug...

journal_title：Molecular and cellular endocrinology

authors： Zhang Z,Teng CT

更新日期：2007-01-29 00:00:00

abstract：:Immature rat testes contain a specific binding protein for testosterone (T) and 5alpha-dihyrotestosterone (DHT) with physico-chemical properties similar to the cytoplasmic androgen receptors in the epididymis and ventral prostate but different from the testicular androgen-binding protein (ABP). Like the androgen recep...

journal_title：Molecular and cellular endocrinology

authors： McLean WS,Smith AA,Hansson V,Naess O,Nayfeh SN,French FS

更新日期：1976-03-01 00:00:00

abstract：:This work was designed to determine whether IGF-1 and EGF modulate nuclear transfer and transactivation of the androgen receptor (AR) in human prostate cell lines (PNT1A and DU-145). We first characterized the IGF-1 and EGF receptors by ligand-binding assays with [125I] IGF-1 and [125I] EGF in a normal human prostate ...

journal_title：Molecular and cellular endocrinology

authors： Orio F Jr,Térouanne B,Georget V,Lumbroso S,Avances C,Siatka C,Sultan C

更新日期：2002-12-30 00:00:00

abstract：:The direct inhibitory of gonadotropin-releasing hormone (GnRH) upon testicular androgen production was studied in cultured testicular cells. Enzyme-dispersed testicular cells from immature hypophysectomized rats were cultured for 6 days in a serum-free medium with or without various hormones. Culture media were change...

journal_title：Molecular and cellular endocrinology

authors： Hsueh AJ,Schreiber JR,Erickson GF

更新日期：1981-01-01 00:00:00

abstract：:Berberine has been shown to have insulin-sensitizing effect, but the molecular mechanism underlying remains elusive. In this work, we investigated the effect of berberine on insulin-induced signal transduction and glucose uptake in both insulin-sensitive and insulin-resistant rat skeletal muscle cells. Berberine incre...

journal_title：Molecular and cellular endocrinology

authors： Liu LZ,Cheung SC,Lan LL,Ho SK,Xu HX,Chan JC,Tong PC

更新日期：2010-04-12 00:00:00

abstract：:Thyroid hormone (TH) modulates serum cholesterol by acting on TH receptor β1 (TRβ1) in liver to regulate metabolic gene sets. In rodents, one important TH regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in...

journal_title：Molecular and cellular endocrinology

authors： Lammel Lindemann JA,Angajala A,Engler DA,Webb P,Ayers SD

更新日期：2014-05-05 00:00:00

abstract：:Set/template-activating factor (TAF)-Ibeta, part of the Set-Can oncogene product found in acute undifferentiated leukemia, is a component of the inhibitor of acetyltransferases (INHAT) complex. Set/TAF-Ibeta interacted with the DNA-binding domain of the glucocorticoid receptor (GR) in yeast two-hybrid screening, and r...

journal_title：Molecular and cellular endocrinology

authors： Ichijo T,Chrousos GP,Kino T

更新日期：2008-02-13 00:00:00

abstract：:Estrogen sulfotransferase (SULT1E1) is a phase II drug-metabolizing enzyme known to catalyze sulfoconjugation of estrogens. 17β-estradiol (E2) plays a pivotal role in attenuating endothelial dysfunction. E2 can be further sulfated to estradiol sulfate (E2S) using SULT1E1. To date, there are no reports of expression an...

journal_title：Molecular and cellular endocrinology

authors： Xu Y,Yang X,Wang Z,Li M,Ning Y,Chen S,Yin L,Li X

更新日期：2013-04-30 00:00:00

abstract：:We previously demonstrated the interactions of different chemical compounds with estrogen receptors ERalpha and ERbeta and the androgen receptor (AR) using different reporter cell lines. In this study, we characterize the ERalpha, ERbeta and AR activity of different biphenyls using the same tools. We provide evidence ...

journal_title：Molecular and cellular endocrinology

authors： Paris F,Balaguer P,Térouanne B,Servant N,Lacoste C,Cravedi JP,Nicolas JC,Sultan C

更新日期：2002-07-31 00:00:00

abstract：:Oxytocin receptors (OT-R) are known to be involved in the course of labor since a massive increase in OT-binding sites is observed in the uterus just before parturition. Vasopressin (AVP)-binding sites have also been observed and have been shown to mediate uterotonic responses. To determine exactly which subtypes of O...

journal_title：Molecular and cellular endocrinology

authors： Clerget MS,Elalouf JM,Germain G

更新日期：1997-12-31 00:00:00

abstract：:SF-1 (steroidogenic factor-1) (NR5A1) and DAX-1 (dosage-sensitive sex-reversal, adrenal hypoplasia congenital, X chromosome) (NR0B1) are orphan nuclear receptors that are expressed in the adrenal gland, gonads, ventromedial hypothalamus (VMH), and pituitary gonadotrope cells. The function of these genes has been clari...

journal_title：Molecular and cellular endocrinology

authors： Achermann JC,Meeks JJ,Jameson JL

更新日期：2001-12-20 00:00:00

abstract：:Both constitutive and ligand-mediated membrane trafficking regulate Epidermal Growth Factor Receptor (EGFR) signaling. The constitutive endocytosis and recycling of the unliganded EGFR is a critical determinant of cell surface EGFR expression and the cell's sensitivity to ligands. We report that two proteins with esta...

journal_title：Molecular and cellular endocrinology

authors： Rush JS,Ceresa BP

更新日期：2013-12-05 00:00:00

abstract：:The type 1 diabetes (T1D) risk locus on chromosome 15q25.1 harbors the candidate gene CTSH (cathepsin H). We previously demonstrated that CTSH regulates β-cell function in vitro and in vivo. CTSH overexpression protected insulin-secreting INS-1 cells against cytokine-induced apoptosis. The purpose of the present study...

journal_title：Molecular and cellular endocrinology

authors： Fløyel T,Mirza AH,Kaur S,Frørup C,Yarani R,Størling J,Pociot F

更新日期：2020-12-01 00:00:00

abstract：:Recently, a defect in pertussis toxin-independent actions of epinephrine on pancreatic B-cells of fa/fa Zucker rats was reported (Cawthorn and Chan (1991) Mol. Cell. Endocrinol. 75, 197-204). We now report studies of islet alpha 2-adrenoceptor function of fa/fa rats. Insulin and cAMP production by islets of obese rats...

journal_title：Molecular and cellular endocrinology

authors： Chan CB,MacPhail RM

更新日期：1992-03-01 00:00:00

abstract：:Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stress response and regulate many physiological processes, including metabolism and immune response. Their release into the blood is highly dynamic and occurs in about hourly pulses, the amplitude of which is modulated in a...

journal_title：Molecular and cellular endocrinology

authors： Dickmeis T,Weger BD,Weger M

更新日期：2013-11-05 00:00:00

abstract：:Prolactin (PRL) modulates proliferation in the mammary gland and other tissues, in part through inducing transcription of cyclin D1, a key regulator of G(1) phase cell cycle progression. We showed previously that PRL, via Jak2, induces binding of Stat5 to a distal GAS site (GAS1) in the cyclin D1 promoter. However, fu...

journal_title：Molecular and cellular endocrinology

authors： Brockman JL,Schuler LA

更新日期：2005-07-15 00:00:00

abstract：:This report summarizes the genome-wide effects of ACTH on transcript accumulation in mouse adrenal Y1 cells and the relative contributions of the cAMP-, protein kinase C- and Ca(2+)-dependent signaling pathways to these actions of the hormone. ACTH affected the accumulation of 1386 transcripts, a much larger number th...

journal_title：Molecular and cellular endocrinology

authors： Schimmer BP,Cordova M,Cheng H,Tsao A,Morris Q

更新日期：2007-02-01 00:00:00

abstract：:Reg family proteins are expressed in the pancreas and involved in pancreatitis and islet β-cell growth. In order to explore transcriptional control, we transfected luciferase reporter genes driven by Reg promoters into acinar AR42J and islet MIN6 cells. Dexamethasone (DEX) significantly increased the promoter expressi...

journal_title：Molecular and cellular endocrinology

authors： Luo C,Li B,Liu L,Yin HP,Wang M,Liu JL

更新日期：2013-01-30 00:00:00

abstract：:T3 effects on myosin heavy chain gene expression were analysed in muscles undergoing different fates during metamorphosis. Muscle fate was followed by somatic gene transfer of a constitutively expressed luciferase vector. Persistent expression was found in dorsal muscle which is remodelled during metamorphosis whilst ...

journal_title：Molecular and cellular endocrinology

authors： Sachs LM,Lebrun JJ,de Luze A,Kelly PA,Demeneix BA

更新日期：1997-08-08 00:00:00

abstract：:Brown adipose tissue (BAT) has been also considered as the main thermogenic organ responsible of maintenance body temperature through heat production. However, a new type of thermogenic fat has been characterized during the last years, the beige or brite fat, that is developed from white adipose tissue (WAT) in respon...

journal_title：Molecular and cellular endocrinology

authors： Contreras C,Nogueiras R,Diéguez C,Medina-Gómez G,López M

更新日期：2016-12-15 00:00:00

abstract：:Estrogen replacement therapy (ERT) is utilized as a major regime for treatment of postmenopausal osteoporosis at present. However, long-term supplement of estrogen may cause uterine hyperplasia and hypertension leading to a high risk of endometrial cancer and breast cancer. Psoralea corylifolia L. has long been used a...

journal_title：Molecular and cellular endocrinology

authors： Weng ZB,Gao QQ,Wang F,Zhao GH,Yin FZ,Cai BC,Chen ZP,Li WD

更新日期：2015-12-05 00:00:00

abstract：:Brown fat has been highlight as a new therapeutic target for treatment of obesity and diabetes. However, molecular mechanism underlying brown adipogenesis are not fully understood. Here, we identified that MAP kinase phosphatase 3 (MKP3) has a novel role as regulator of brown adipocyte differentiation. The expression ...

journal_title：Molecular and cellular endocrinology

authors： Kim WK,Oh KJ,Choi HR,Park A,Han BS,Chi SW,Kim SJ,Bae KH,Lee SC

更新日期：2015-11-15 00:00:00

abstract：:Aldosterone plays an important role in electrolyte and blood pressure homeostasis. Our studies have focused on the role of aldosterone in essential hypertension. We have shown that plasma aldosterone and ARR are heritable characteristics and that aldosterone concentrations in older subjects are inversely correlated wi...

journal_title：Molecular and cellular endocrinology

authors： Davies E,Mackenzie SM,Freel EM,Alvarez-Madrazo S,Fraser R,Connell JM

更新日期：2009-03-05 00:00:00

abstract：:Resistance to thyroid hormone can be due to heterozygous, dominant negative (DN) THRA (RTHα) or THRB (RTHβ) mutations, but the underlying mechanisms are incompletely understood. Here, we delineate the spatiotemporal expression of TH receptors (TRs) in zebrafish and generated morphants expressing equivalent amounts of ...

journal_title：Molecular and cellular endocrinology

authors： Marelli F,Carra S,Agostini M,Cotelli F,Peeters R,Chatterjee K,Persani L

更新日期：2016-03-15 00:00:00

abstract：:The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to m...

journal_title：Molecular and cellular endocrinology

authors： Anderson PH,Atkins GJ,Turner AG,Kogawa M,Findlay DM,Morris HA

更新日期：2011-12-05 00:00:00

abstract：:Prenatal testosterone (T)-treated female sheep exhibit an enhanced inflammatory and oxidative stress state in the visceral adipose tissue (VAT) but not in the subcutaneous (SAT), while surprisingly maintaining insulin sensitivity in both depots. In adult sheep, adipose tissue is predominantly composed of white adipocy...

journal_title：Molecular and cellular endocrinology

authors： Puttabyatappa M,Ciarelli JN,Chatoff AG,Singer K,Padmanabhan V

更新日期：2020-03-01 00:00:00

abstract：:The expression of the three genes encoding the components C1, C2 and C3 of prostatic binding protein (PBP) is under androgen control and restricted to the rat ventral prostate. The SstI-PvuII fragment of the first intron of the C3(1) gene displays two binding sites for ubiquitous transcription factors and one for a ti...

journal_title：Molecular and cellular endocrinology

authors： Celis L,Claessens F,Peeters B,Heyns W,Verhoeven G,Rombauts W

更新日期：1993-08-01 00:00:00

abstract：:The beneficial effects of empagliflozin (EMPA) on cardiac functions during ischemia and reperfusion were characterized. The contractile functions of isolated cardiomyocytes from adult C57BL/6J mice were determined with IonOptix SoftEdgeMyoCam system. The mitochondrial superoxide production was measured by MitoSOX fluo...

journal_title：Molecular and cellular endocrinology

authors： Lu Q,Liu J,Li X,Sun X,Zhang J,Ren D,Tong N,Li J

更新日期：2020-02-05 00:00:00

abstract：:Procedures have been developed which provide simple means of determining binding constants of steroid receptors for glucocorticoids in mouse lymphoid cell lines and of characterizing the interaction of the steroid--receptor complex with the nucleus. An average of 70% of the steroid--receptor complexes is found associa...

journal_title：Molecular and cellular endocrinology

authors： Pfahl M,Sandros T,Bourgeois S

更新日期：1978-04-01 00:00:00

abstract：:Cyclic ewes were treated with control vehicle or progesterone receptor antagonist (onapristone; 100mg i.m. twice daily) during either early (day 3-5) or late (day 12-14) luteal phase and plasma samples collected for hormone analysis and to determine endogenous and oxytocin induced PGF2α release. On day 14 and 17, ewes...

journal_title：Molecular and cellular endocrinology

authors： Mann GE,Wathes DC,Robinson RS

更新日期：2013-08-25 00:00:00