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Functional characterization of alpha-adrenoceptors on pancreatic islets of fa/fa Zucker rats.

Abstract：

:Recently, a defect in pertussis toxin-independent actions of epinephrine on pancreatic B-cells of fa/fa Zucker rats was reported (Cawthorn and Chan (1991) Mol. Cell. Endocrinol. 75, 197-204). We now report studies of islet alpha 2-adrenoceptor function of fa/fa rats. Insulin and cAMP production by islets of obese rats were both inhibited by the alpha 2-adrenoceptor agonist clonidine. Calculated pD2 values for clonidine were 9.57 +/- 0.59 and 9.43 +/- 0.33 for lean and fa/fa rat islets, respectively. Yohimbine reversed clonidine effects equipotently in lean and obese rat islets (pA2 values of 7.48 +/- 0.57 vs 7.43 +/- 0.58). Unexpectedly, the alpha 1-antagonist prazosin stimulated insulin secretion from islets of obese but not lean rats. Functional characteristics of the alpha-adrenoceptors on fa/fa islets are thus similar to those recently designated alpha 2B. Altered expression of alpha-adrenoceptors on pancreatic islets of fa/fa rats may contribute to changes in the pertussis toxin-independent pathway of epinephrine action previously observed.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Chan CB,MacPhail RM

doi

10.1016/0303-7207(92)90068-h

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

33-7

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

0303-7207(92)90068-H

journal_volume

84

pub_type

杂志文章

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