The progesterone receptor antagonist, onapristone has differential effects on the timing and control of the luteolytic mechanism depending on timing of administration in sheep.

abstract：:The fish reproductive axis is regulated by many neuroendocrine factors. However, factors involved in the suppression of this axis are largely uncharacterized. In this study, we describe a novel neuropeptide derived from the spexin precursor acting as a negative factor to suppress the reproductive axis in teleost. The ...

journal_title：Molecular and cellular endocrinology

authors： Liu Y,Li S,Qi X,Zhou W,Liu X,Lin H,Zhang Y,Cheng CH

更新日期：2013-07-15 00:00:00

abstract：:In the marmoset monkey, the LHR type II, lacking exon 10, is the native receptor type. We characterised the LHR splicing pattern in marmoset testes and the adrenals during puberty and in pre- and postpubertal ovaries and quantified mRNA LHR expression in the testis. We detected 11 LHR splicing variants expressed at si...

journal_title：Molecular and cellular endocrinology

authors： Michel C,Gromoll J,Chandolia R,Luetjens CM,Wistuba J,Simoni M

更新日期：2007-12-15 00:00:00

abstract：:Lymphocyte cell lines were established from five patients with vitamin D-dependent rickets, type II (VDDR-II). These lines were established by infection with human T-lymphotrophic virus type I (HTLV-I). Binding of [3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) to its receptor in these cell lines was compared to bind...

journal_title：Molecular and cellular endocrinology

authors： Koeffler HP,Bishop JE,Reichel H,Singer F,Nagler A,Tobler A,Walka M,Norman AW

更新日期：1990-03-26 00:00:00

abstract：:As part of an ongoing study of the cell-specific expression of glandular kallikrein genes in mice, we have investigated cellular sites of expression of the renal/pancreatic kallikrein gene, mGK-6, during fetal life. Expression of alpha I and beta-subunit genes of Na+K+ATPase and bradykinin binding were used as an indi...

journal_title：Molecular and cellular endocrinology

authors： Penschow JD,Coghlan JP

更新日期：1992-10-01 00:00:00

abstract：:TRESK (TWIK-related spinal cord K(+) channel, KCNK18) belongs to the two-pore domain (K2P) background (leak) potassium channel family. Unlike other K2P channels, TRESK is activated by the calcium signal in heterologous expression systems. The activation is mediated by the calcium/calmodulin-dependent protein phosphata...

journal_title：Molecular and cellular endocrinology

authors： Enyedi P,Braun G,Czirják G

更新日期：2012-04-28 00:00:00

abstract：:Bisphenol A (BPA) and para-Nonylphenol (p-NP) are chemicals of industrial origin which may influence human reproductive health. The effects of these substances in the prenatal life is an important topic that is receiving greater attention in the developed countries. In this study, human trophoblast cells HTR-8/SVneo w...

journal_title：Molecular and cellular endocrinology

authors： Spagnoletti A,Paulesu L,Mannelli C,Ermini L,Romagnoli R,Cintorino M,Ietta F

更新日期：2015-09-05 00:00:00

abstract：:The so-called calcium antagonist D-600 and agents that enhance the influx of calcium ions into nerve terminals during action potentials (4-aminopyridine, tetraethylammonium, guanidine) interact with alpha-adrenoceptors. The interaction was revealed by binding experiments in vitro with the alpha 2- and alpha 1-specific...

journal_title：Molecular and cellular endocrinology

authors： Glossmann H,Hornung R

更新日期：1980-09-01 00:00:00

abstract：:The study aims to examine the effects of restraint, cold, and in combination of hypoxia on pituitary GH mRNA and hepatic IGF-I mRNA and its protein in rats, and the potential involvement of corticotropin-releasing factor receptor subtype 1 (CRFR1) and SS in mediating the effects of continual hypoxia. Continual or inte...

journal_title：Molecular and cellular endocrinology

authors： Chen XQ,Xu NY,Du JZ,Wang Y,Duan C

更新日期：2005-10-20 00:00:00

abstract：:The interaction between corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) is important in the regulation of adrenocorticotropin (ACTH) release from the anterior pituitary (AP). CRF exerts its effect on the AP by activating the adenylate cyclase (AC) complex whereas AVP increases the turnover of phosp...

journal_title：Molecular and cellular endocrinology

authors： Liu JP,Robinson PJ,Funder JW,Engler D

更新日期：1994-05-01 00:00:00

abstract：:Prenatal testosterone (T)-treated female sheep exhibit an enhanced inflammatory and oxidative stress state in the visceral adipose tissue (VAT) but not in the subcutaneous (SAT), while surprisingly maintaining insulin sensitivity in both depots. In adult sheep, adipose tissue is predominantly composed of white adipocy...

journal_title：Molecular and cellular endocrinology

authors： Puttabyatappa M,Ciarelli JN,Chatoff AG,Singer K,Padmanabhan V

更新日期：2020-03-01 00:00:00

abstract：:Calcium salts were found to replace ACTH in inducing steroidogenesis in isolated adrenocortical cells from rats. This Ca-specific stimulation occurred when the cation was presented to the cells in the presence of phosphate and carbonate as a counter-ions under conditions which favoured the formation of colloidal calci...

journal_title：Molecular and cellular endocrinology

authors： Neher R,Milani A

更新日期：1978-01-01 00:00:00

abstract：:Bovine adrenocortical cells were transplanted into scid mice, using a small cylinder inserted beneath the kidney capsule. The tissue formed from primary bovine adrenocortical cells replaced the essential functions of the animals' own adrenal glands, which were removed during the cell transplantation procedure. Most ad...

journal_title：Molecular and cellular endocrinology

authors： Thomas M,Hornsby PJ

更新日期：1999-07-20 00:00:00

abstract：:The conversion of 3 beta-hydroxy-5-ene steroids by the enzyme complex 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) is an obligatory step in the biosynthesis of all classes of hormonal steroids in classical steroidogenic as well as in peripheral tissues. To develop a model more closely rel...

journal_title：Molecular and cellular endocrinology

authors： Simard J,Melner MH,Breton N,Low KG,Zhao HF,Periman LM,Labrie F

更新日期：1991-02-01 00:00:00

abstract：:The fibromuscular stroma (FMS) separated from the seminal vesicles of adult guinea pigs incorporated [35S]methionine into a 12 500 X g soluble fraction in vitro. Incorporation decreased 60% in tissues from 7-day castrates with no further change up to 21 days post-castration. Administration of 5 alpha-dihydrotestostero...

journal_title：Molecular and cellular endocrinology

authors： Weinberger MJ

更新日期：1984-12-01 00:00:00

abstract：:Poly(A+)-containing mRNA from human term placenta was used to direct protein synthesis in a nuclease-treated rabbit reticulocyte lysate, which is dependent on mRNA and tRNA for maximal activity. The major protein product was human pre-placental lactogen (hPL). Addition of tRNA from rabbit liver, rabbit reticulocyte, h...

journal_title：Molecular and cellular endocrinology

authors： Kelly SJ,Loria J,Gyves MT,Ilan J

更新日期：1983-02-01 00:00:00

abstract：:Inhibin production by cultured granulosa cells from immature diethylstilbestrol (DES)-primed rats was studied in relation to estradiol and progesterone production. The inhibin content in culture media was assayed with a specific radioimmunoassay (RIA) using an antibody to porcine 32 kDa inhibin that recognizes rat inh...

journal_title：Molecular and cellular endocrinology

authors： Suzuki T,Miyamoto K,Hasegawa Y,Abe Y,Ui M,Ibuki Y,Igarashi M

更新日期：1987-12-01 00:00:00

abstract：:Adenylate cyclase activity and its modulation by guanine nucleotides and isoproterenol were assessed in adipocyte membranes of mice with mutations causing different genetic obesity syndromes. The object was to determine whether the defect in inhibitory modulation observed in the obese (ob/ob) mouse was also present in...

journal_title：Molecular and cellular endocrinology

authors： Bégin-Heick N,Coleman DL

更新日期：1988-10-01 00:00:00

abstract：:Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Fo...

journal_title：Molecular and cellular endocrinology

authors： Chu R,Liu SY,Vlantis AC,van Hasselt CA,Ng EK,Fan MD,Ng SK,Chan AB,Du J,Wei W,Liu X,Liu Z,Chen GG

更新日期：2015-01-05 00:00:00

abstract：:In order to differentiate whether activation of NaK-ATPase in thyroid thermogenesis is due to increased numbers of active 'sodium pump' units or due to a change in the kinetics of the enzyme, the effect of T3 on activation energy (Ea) of NaK-ATPase was determined in rat liver, kidney and brain. Injection of T3 produce...

journal_title：Molecular and cellular endocrinology

authors： Rahimifar M,Ismail-Beigi

更新日期：1977-02-01 00:00:00

abstract：:This study was aimed at testing the hypothesis that epidermal growth factor (EGF) can modulate the gonadotropin-dependent differentiation of theca-interstitial cells in vitro. Addition of EGF to chemically defined culture medium severely antagonized the ability of hCG to transform undifferentiated theca-interstitial c...

journal_title：Molecular and cellular endocrinology

authors： Erickson GF,Case E

更新日期：1983-07-01 00:00:00

abstract：:Relaxin (RLX) is an insulin-like polypeptide hormone that was initially introduced for its pregnancy-related function. Subsequent studies revealed that RLX possesses anti-fibrotic functions in tumors and nonreproductive tissues, such as skin, lungs, and others. This aspect of the RLX has been explored for the treatmen...

journal_title：Molecular and cellular endocrinology

authors： Hong J,Yun CO

更新日期：2019-05-01 00:00:00

abstract：:The effects of tamoxifen (Tam) and its 4-hydroxylated metabolite (OH-Tam) on the growth of two human breast cancer cell lines ( MCF7 and BT20 ) were evaluated by fluorometric DNA assay. The effects of the antiestrogens were dependent upon their concentrations and the nature of the cells. At concentrations below 4 micr...

journal_title：Molecular and cellular endocrinology

authors： Bardon S,Vignon F,Derocq D,Rochefort H

更新日期：1984-05-01 00:00:00

abstract：:Thyroid hormone pretreatment was indicated to increase tissue tolerance to ischemia-reperfusion injury (IRI) in various organs, but the underlying molecular mechanisms remains largely unknown. Induction of heme oxygenase-1 (HO-1) protects organs against IRI. The present study investigated the effect of thyroid hormone...

journal_title：Molecular and cellular endocrinology

authors： Li F,Lu S,Zhu R,Zhou Z,Ma L,Cai L,Liu Z

更新日期：2011-06-06 00:00:00

abstract：:The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includ...

journal_title：Molecular and cellular endocrinology

authors： Zambrano E,Guzmán C,Rodríguez-González GL,Durand-Carbajal M,Nathanielsz PW

更新日期：2014-01-25 00:00:00

abstract：:The antiestrogen tamoxifen has been successfully used to control estrogen receptor (ER) and progesterone receptor positive breast cancer. However, the development of antiestrogen resistance is frequently observed in patients following long term treatment. We have studied the development of antiestrogen resistance in v...

journal_title：Molecular and cellular endocrinology

authors： Jiang SY,Wolf DM,Yingling JM,Chang C,Jordan VC

更新日期：1992-12-01 00:00:00

abstract：:Yin Yang 1 (YY1) is an ubiquitously distributed transcription factor that belongs to the GLI-Kruppel class of zinc finger proteins. The mechanism by which YY1 regulates adipocyte differentiation remains unclear. In this study, we investigated the functional role of YY1 during adipocyte differentiation. During the earl...

journal_title：Molecular and cellular endocrinology

authors： Han Y,Choi YH,Lee SH,Jin YH,Cheong H,Lee KY

更新日期：2015-09-15 00:00:00

abstract：:Autodigestion of nuclei isolated from the androgen-dependent Shionogi mouse mammary carcinoma revealed the presence of endogenous endonuclease activity which was stimulated by Ca2+ and Mg2+ and generated a repeating pattern of DNA fragments with an average monomeric size of 179 base pairs. The nuclear concentration of...

journal_title：Molecular and cellular endocrinology

authors： Giles MG,Rennie PS,Bruchovsky N

更新日期：1986-05-01 00:00:00

abstract：:Several common KCNQ1 gene polymorphisms have been associated with the risk of type 2 diabetes (T2DM) and diabetic nephropathy. This effect is explained by the role of the kcnq1 protein as a potassium channel that in the pancreatic beta-cells drives an electrical signal that facilitates glucose-stimulated insulin secre...

journal_title：Molecular and cellular endocrinology

authors： Riobello C,Gómez J,Gil-Peña H,Tranche S,Reguero JR,de la Hera JM,Delgado E,Calvo D,Morís C,Santos F,Coto-Segura P,Iglesias S,Alonso B,Alvarez V,Coto E

更新日期：2016-05-15 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase. ADMA accumulation, mainly due to a decreased dimethylarginine dimethylaminohydrolase (DDAH) activity, has been related to the development of cardiovascular diseases. We investigate whether estradiol prevents the changes induce...

journal_title：Molecular and cellular endocrinology

authors： Novella S,Laguna-Fernández A,Lázaro-Franco M,Sobrino A,Bueno-Betí C,Tarín JJ,Monsalve E,Sanchís J,Hermenegildo C

更新日期：2013-01-05 00:00:00

abstract：:Previous studies have shown that disruption or damage to the seminiferous tubules by radiation, antiandrogen, vitamin A deficiency or experimental cryptorchidism causes Leydig cell hypertrophy and hyperplasia, suggesting that Sertoli cells secrete a mitogenic factor(s) that stimulates Leydig cell proliferation. To stu...

journal_title：Molecular and cellular endocrinology

authors： Wu N,Murono EP

更新日期：1994-12-01 00:00:00