当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Compositional analysis and biological characterization of Cornus officinalis on human 1.1B4 pancreatic β cells.

Compositional analysis and biological characterization of Cornus officinalis on human 1.1B4 pancreatic β cells.

Abstract：

:Type 1 diabetes (T1D) is an autoimmune disease resulting from the loss of pancreatic β cells and subsequent insulin production. Novel interventional therapies are urgently needed that can protect existing β cells from cytokine-induced death and enhance their function before symptomatic onset. Our initial evidence is suggesting that bioactive ingredients within Cornus officinalis (CO) may be able to serve in this function. CO has been extensively used in Traditional Chinese Medicine (TCM) and reported to possess both anti-inflammatory and pro-metabolic effects. We hypothesize that CO treatment may provide a future potential candidate for interventional therapy for early stage T1D prior to significant β cell loss. Our data demonstrated that CO can inhibit cytokine-mediated β cell death, increase cell viability and oxidative capacity, and increase expression of NFATC2 (Nuclear Factor of Activated T Cells, Cytoplasmic 2). We have also profiled the bioactive components in CO from multiple sources by HPLC/MS (High Performance Liquid Chromatography/Mass Spectrometry) analysis. Altogether, CO significantly increases the energy metabolism of β cells while inducing the NFAT pathway to signal for increased proliferation and endocrine function.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Sharp-Tawfik AE,Coiner AM,MarElia CB,Kazantzis M,Zhang C,Burkhardt BR

doi

10.1016/j.mce.2019.110491

subject

Has Abstract

pub_date

2019-08-20 00:00:00

pages

110491

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(19)30193-5

journal_volume

494

pub_type

杂志文章

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