Abstract:
:This study examines the effect of preincubation of sheep ovarian follicles with hCG or FSH on the ability of isolated theca and granulosa to increase cAMP levels in response to a second incubation with hCG or FSH. Secondly, the effect of preincubation of small follicles with hCG on androstenedione and testosterone production is examined in intact follicles. Preincubation with hCG resulted in a decrease in the ability of theca from large (4--6 mm in diameter) and small (1--3 mm) follicles and granulosa from large follicles to increase cAMP levels in response to a second exposure to hCG. Similarly, preincubation with FSH suppressed the response of isolated granulosa from small and large follicles to a second exposure to FSH. A partial, but significant inhibition of the response to the other hormone was observed after preincubation with both FSH and hCG. Intact small follicles pretreated with hCG were unable to increase testosterone secretion in response to a second exposure to hCG.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Weiss TJ,Armstrong DTdoi
10.1016/0303-7207(79)90083-2subject
Has Abstractpub_date
1979-03-01 00:00:00pages
229-39issue
3eissn
0303-7207issn
1872-8057journal_volume
13pub_type
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journal_title:Molecular and cellular endocrinology
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