Abstract:
:The transforming growth factor-beta (TGF-beta) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which when activated mediate gene transcription. Some members of the superfamily, notably activin, TGF-beta, GDF-9 and the bone morphogenetic proteins have been shown to influence ovarian function. Despite these actions, TGF-beta superfamily signalling pathways and specifically those within follicle population subtypes, have been poorly characterised in the ovary. We have shown that the ovary contains type I and II receptors and Smads, which enable it to transduce signals in response to TGF-beta superfamily members. It remains to be established however, as to which follicle subtypes these pathways are active in.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Drummond AE,Dyson M,Le MT,Ethier JF,Findlay JKdoi
10.1016/s0303-7207(03)00062-5keywords:
subject
Has Abstractpub_date
2003-04-28 00:00:00pages
53-7issue
1-2eissn
0303-7207issn
1872-8057pii
S0303720703000625journal_volume
202pub_type
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