Designing a new generation of anti-hCG vaccines for cancer therapy.

abstract：:Thyroid hormones participate in the regulation of growth, development and energy expenditure of vertebrates. Type I (D1) and type II 5'deiodinases catalyze the peripheral conversion of the thyroid prohormone thyroxine to the active form triiodothyronine (T3). D1 is expressed in organs like liver, thyroid, and lactatin...

journal_title：Molecular and cellular endocrinology

authors： García-Solís P,Aceves C

更新日期：2003-03-28 00:00:00

abstract：:This study was aimed at testing the hypothesis that epidermal growth factor (EGF) can modulate the gonadotropin-dependent differentiation of theca-interstitial cells in vitro. Addition of EGF to chemically defined culture medium severely antagonized the ability of hCG to transform undifferentiated theca-interstitial c...

journal_title：Molecular and cellular endocrinology

authors： Erickson GF,Case E

更新日期：1983-07-01 00:00:00

abstract：:A new analogue of recombinant human growth hormone (hGH), hGH des(1-6,14) was expressed in Escherichia coli, refolded and purified to homogeneity. The mutation decreased the hormone's ability to bind lactogenic and somatogenic receptors through its site 1, and almost completely abolished its ability to bind these rece...

journal_title：Molecular and cellular endocrinology

authors： Tchelet A,Vogel T,Helman D,Guy R,Neospouolus C,Goffin V,Djiane J,Gertler A

更新日期：1997-06-20 00:00:00

abstract：:Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related ...

journal_title：Molecular and cellular endocrinology

authors： Crisóstomo L,Pereira SC,Monteiro MP,Raposo JF,Oliveira PF,Alves MG

更新日期：2020-10-01 00:00:00

abstract：:Visceral obesity is an independent risk factor for metabolic syndrome, and abnormal fat accumulation is linked to increases in the number and size of adipocytes. MiR-146b was a miRNA highly expressed in mature adipocytes while very lowly expressed in human mesenchymal stem cells (hMSCs) and human visceral preadipocyte...

journal_title：Molecular and cellular endocrinology

authors： Chen L,Dai YM,Ji CB,Yang L,Shi CM,Xu GF,Pang LX,Huang FY,Zhang CM,Guo XR

更新日期：2014-08-05 00:00:00

abstract：:Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroe...

journal_title：Molecular and cellular endocrinology

authors： Vandenput L,Ohlsson C

更新日期：2014-01-25 00:00:00

abstract：:The ability of angiotensin-II (A-II) to increase cAMP production in adrenocortical cells is not widely accepted due to numerous conflicting reports. The recent observation that rat adrenal cells exhibit multiple subtypes of A-II receptors raises the possibility that a specific subtype could be responsible for controll...

journal_title：Molecular and cellular endocrinology

authors： Rainey WE,Byrd EW,Sinnokrot RA,Carr BR

更新日期：1991-10-01 00:00:00

abstract：:Lymphocyte cell lines were established from five patients with vitamin D-dependent rickets, type II (VDDR-II). These lines were established by infection with human T-lymphotrophic virus type I (HTLV-I). Binding of [3H]1 alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) to its receptor in these cell lines was compared to bind...

journal_title：Molecular and cellular endocrinology

authors： Koeffler HP,Bishop JE,Reichel H,Singer F,Nagler A,Tobler A,Walka M,Norman AW

更新日期：1990-03-26 00:00:00

abstract：:Animal and 'in vitro' experiences learned that human chorionic gonadotropin (hCG) is capable to protect from breast cancer. Receptors for hCG/luteinizing hormone (LH) are present on human female and male breast cancer cells. hCG decreases proliferation and invasion of breast cancer MCF-7 cells by inhibiting NF-kappa B...

journal_title：Molecular and cellular endocrinology

authors： Janssens JP,Russo J,Russo I,Michiels L,Donders G,Verjans M,Riphagen I,Van den Bossche T,Deleu M,Sieprath P

更新日期：2007-04-15 00:00:00

abstract：:We have previously shown that osteocalcin synthesis is readily induced by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in MG-63 human osteosarcoma cells (Mahonen et al. (1990) Biochim. Biophys. Acta 1048, 30-37). In the present study, the regulation of osteocalcin synthesis by other hormones of the steroid-thyroid hormone f...

journal_title：Molecular and cellular endocrinology

authors： Pirskanen A,Mahonen A,Mäenpää PH

更新日期：1991-04-01 00:00:00

abstract：:Northern blot analysis of total RNA from a variety of rabbit tissues indicated that placenta is the primary site of expression of the protein hormone relaxin (previously called SQ10) in rabbits. Relaxin was not detected by this method in other rabbit tissues, including normal trachea and several squamous tissues. Howe...

journal_title：Molecular and cellular endocrinology

authors： Bernacki SH,Medvedev A,Holloway G,Dawson M,Lotan R,Jetten AM

更新日期：1998-03-16 00:00:00

abstract：:Stanniocalcin (STC) (formerly known as both teleocalcin and hypocalcin) is an anti-hypercalcemic, glycoprotein hormone that is produced by the corpuscles of Stannius (CS), endocrine glands that are confined to bony fishes. The hormone has a unique amino acid sequence and exists as a disulfide-linked homodimer in the n...

journal_title：Molecular and cellular endocrinology

authors： Wagner GF,Dimattia GE,Davie JR,Copp DH,Friesen HG

更新日期：1992-12-01 00:00:00

abstract：:In order to define the possible involvement of proteoglycans (PG) in the regulation of Sertoli cell functions, we have examined the effect of para-nitrophenyl-beta-D-xyloside (PNPX), a specific inhibitor of PG synthesis, on follicle stimulating hormone (FSH)-dependent estradiol production by immature rat Sertoli cells...

journal_title：Molecular and cellular endocrinology

authors： Phamantu NT,Bonnamy PJ,Bouakka M,Bocquet J

更新日期：1995-03-01 00:00:00

abstract：:We previously described an androgen receptor (AR) point mutation located in the DNA-binding domain (DBD), adjacent to another AR substitution. Both were observed in two unrelated families with male breast cancer (MBC) and partial androgen insensitivity syndrome. This work was designed to determine the potential role o...

journal_title：Molecular and cellular endocrinology

authors： Poujol N,Lobaccaro JM,Chiche L,Lumbroso S,Sultan C

更新日期：1997-06-20 00:00:00

abstract：:Wilms' tumour is a childhood kidney cancer, and a classic example of cancer arising through disrupted development (Armstrong et al., 1992). It is one of the most common solid paediatric malignancies, affecting one in 10000 children. The genetics of Wilms' tumour is complicated, with several different genes or chromoso...

journal_title：Molecular and cellular endocrinology

authors： Schedl A,Hastie N

更新日期：1998-05-25 00:00:00

abstract：:The effects of cholera toxin on the responses of cultured Sertoli cells were compared with those elicited by follicle-stimulating hormone (FSH), and N6O2'-dibutyryl-3',5'-cyclic AMP (bu2cAMP). Addition of FSH or cholera toxin increased cAMP levels. Subsequently there was greater rates of conversion of testosterone to ...

journal_title：Molecular and cellular endocrinology

authors： Fritz IB,Griswold MD,Louis BG,Dorrington JH

更新日期：1976-08-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare neuroendocrine neoplasm of the parafollicular thyroid C cells. Although somatostatin receptors are expressed by MTCs, treatment with octreotide has shown poor efficacy, whereas recently pasireotide has demonstrated antiproliferative effects in persistent postoperative MTCs. ...

journal_title：Molecular and cellular endocrinology

authors： Giardino E,Catalano R,Mangili F,Barbieri AM,Treppiedi D,Elli FM,Dolci A,Contarino A,Spada A,Arosio M,Mantovani G,Peverelli E

更新日期：2021-01-15 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by an abnormal oxidative metabolism, but the underlying mechanisms remain to be defined. To uncover potential mechanisms involved in the pathophysiology of diabetic cardiomyopathy, we performed a gene expression profiling study in hearts of diabetic db/db mice. Diabetic hearts ...

journal_title：Molecular and cellular endocrinology

authors： Lasheras J,Vilà M,Zamora M,Riu E,Pardo R,Poncelas M,Cases I,Ruiz-Meana M,Hernández C,Feliu JE,Simó R,García-Dorado D,Villena JA

更新日期：2016-07-15 00:00:00

abstract：:Digital video imaging indicated that about 80% of fura-2-loaded single human thyroid cells responded to TSH, resulting in an increase in intracellular Ca2+ concentration ([Ca2+]i). Most of the TSH-sensitive cells further responded to N6-(L-2-phenylisopropyl)-adenosine (PIA) showing a transient [Ca2+]i rise in a PIA do...

journal_title：Molecular and cellular endocrinology

authors： Yanagita Y,Okajima F,Sho K,Nagamachi Y,Kondo Y

更新日期：1996-04-19 00:00:00

abstract：:Endocrine disrupting chemicals are known to cause neurodevelopmental toxicity through direct and indirect pathways. In this study we used data from the National Health and Nutrition Examination Surveys, along with known exposure-disease relationships, to quantify the intellectual disability burden attributable to in u...

journal_title：Molecular and cellular endocrinology

authors： Gaylord A,Osborne G,Ghassabian A,Malits J,Attina T,Trasande L

更新日期：2020-02-15 00:00:00

abstract：:Two cAMP-dependent protein kinase activities can be separated from rat thyroid cytosol. Their elution properties during the gel chromatography, as well as their sedimentation coefficients after sucrose-gradient ultracentrifugation and their capacity to dissociate in the presence of histones, suggest they are like the ...

journal_title：Molecular and cellular endocrinology

authors： Delbauffe D,Ohayon R,Pavlovic-Hournac M

更新日期：1979-05-01 00:00:00

abstract：:Men have had a substantially higher risk of developing bladder cancer than women. This has prompted research on androgen-mediated androgen receptor (AR) signaling in urothelial cancer. Indeed, increasing preclinical evidence indicates that AR activation correlates with the promotion of urothelial carcinogenesis and tu...

journal_title：Molecular and cellular endocrinology

authors： Inoue S,Mizushima T,Miyamoto H

更新日期：2018-04-15 00:00:00

abstract：:We have carried out further in vitro studies on the priming effect of LH-RH and the effect of steroids on pituitary responsiveness to LH-RH. In hemipituitary glands, the priming effect could be elicited only once within an 11-h period and was found to diminish significantly with time after the first exposure to LH-RH....

journal_title：Molecular and cellular endocrinology

authors： Speight A,Fink G

更新日期：1981-12-01 00:00:00

abstract：:Rats deficient in vitamin A express low levels of P4502C7 mRNA in the liver. Administration of all-trans retinoic acid (at-RA) or growth hormone (GH) to deficient animals only partially restored the expression whereas the combined treatment returned the P4502C7 mRNA levels to that observed in normal rats. That a retin...

journal_title：Molecular and cellular endocrinology

authors： Westin S,Sonneveld E,van der Leede BM,van der Saag PT,Gustafsson JA,Mode A

更新日期：1997-05-16 00:00:00

abstract：:The Ca2+ dependency of the direct stimulatory effect of the gonadotropin-releasing hormone (GnRH) agonist analog [D-Ser(t-Bu)6]des-Gly10-GnRH-N-ethylamide (GnRHa) on progesterone production was investigated and compared to that of luteinizing hormone (LH) in rat granulosa cells from preovulatory follicles. Removal of ...

journal_title：Molecular and cellular endocrinology

authors： Eckstein N,Eshel A,Eli Y,Ayalon D,Naor Z

更新日期：1986-09-01 00:00:00

abstract：:We have used a new methodology to generate a monospecific antiserum to the corticotropin (ACTH) receptor on mouse Y-1 adrenal cells. Using immunoaffinity chromatography the ACTH receptor was purified, and the molecular structure and 125I-ACTH binding characteristics were determined. A molecular weight (Mr) of 225 000 ...

journal_title：Molecular and cellular endocrinology

authors： Bost KL,Blalock JE

更新日期：1986-01-01 00:00:00

abstract：:Knowledge of the mechanisms of single dominant follicle selection has led to the development of a novel and effective ovulation induction regimen for anovulatory women; the step down protocol. This commences with a fixed high gonadotropin dose followed by several decremental steps. For some patients the initial dose i...

journal_title：Molecular and cellular endocrinology

authors： Macklon NS,Fauser BC

更新日期：2002-01-25 00:00:00

abstract：:Near the completion of growth, mammalian oocytes acquire the competence to resume and complete meiosis. In vivo the preovulatory LH surge triggers the resumption of meiosis in the oocyte contained in preovulatory follicles. When immature oocytes and the surrounding cumulus cells are released from their follicular envi...

journal_title：Molecular and cellular endocrinology

authors： Bevers MM,Izadyar F

更新日期：2002-11-29 00:00:00

abstract：:It is well known that ovulation is induced by luteinizing hormone (LH) surge. However, the down-stream factors that mediating LH surge induced ovulation are less clear. The cyclooxygenases (also known as PTGS) as key enzymes for prostaglandins synthesis appear to be important for ovulation in mammals, but their functi...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Liu Y,Li J,Li G,Chen Y,Yin Y,Guo Y,Cheng CH,Liu X,Lin H

更新日期：2017-05-15 00:00:00

abstract：:Recently, a remarkable progress has been made in our understanding about the role of sex steroids in male physiology. In this paper, we consider the clinical aspects of congenital estrogen deficiency - notably, estrogen resistance and aromatase deficiency - in men and we discuss both well-established and supposed estr...

journal_title：Molecular and cellular endocrinology

authors： Rochira V,Balestrieri A,Madeo B,Baraldi E,Faustini-Fustini M,Granata AR,Carani C

更新日期：2001-06-10 00:00:00