StAR protein is increased by muscarinic receptor activation in human luteinized granulosa cells.

abstract：:Podocyte apoptosis in glomerular lesions has been found to have a dominant role in the progression of diabetic nephropathy. The present research aimed to explore the beneficial effect of icariin on diabetic podocytes by interfering in the process of apoptosis. Podocyte apoptosis was significantly exacerbated after hig...

journal_title：Molecular and cellular endocrinology

authors： Qiao C,Ye W,Li S,Wang H,Ding X

更新日期：2018-09-15 00:00:00

abstract：:Mammalian spermatozoa undergo several signaling and biochemical transformations in the female genital tract, collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, where it undergoes the acrosome reaction (AR), a process enabling it to penetrate and fertilize the egg. Actin pol...

journal_title：Molecular and cellular endocrinology

authors： Breitbart H,Rotman T,Rubinstein S,Etkovitz N

更新日期：2010-01-27 00:00:00

abstract：:The effects of calcitonin (CT) on the cellular transport and accumulation of Ca were studied in bone cells grown in primary culture. The following sequence of events was detected: (1) After 1--2 h of incubation with CT the initial rate of Ca influx into bone cells transiently increased. A longer incubation with CT (3-...

journal_title：Molecular and cellular endocrinology

authors： Eilam Y,Szydel N,Harell A

更新日期：1980-06-01 00:00:00

abstract：:The modulation of cardiac growth by estrogen in healthy mice is not completely understood. The aim was to investigate the effects of estrogen on cardiac growth in healthy mice lacking either estrogen receptor (ER) α or β. Wild-type (WT), ERα knockout (ERKO) and ERβ knockout (BERKO) 2-month-old mice were ovariectomized...

journal_title：Molecular and cellular endocrinology

authors： Kararigas G,Nguyen BT,Jarry H

更新日期：2014-02-15 00:00:00

abstract：:The beneficial effects of empagliflozin (EMPA) on cardiac functions during ischemia and reperfusion were characterized. The contractile functions of isolated cardiomyocytes from adult C57BL/6J mice were determined with IonOptix SoftEdgeMyoCam system. The mitochondrial superoxide production was measured by MitoSOX fluo...

journal_title：Molecular and cellular endocrinology

authors： Lu Q,Liu J,Li X,Sun X,Zhang J,Ren D,Tong N,Li J

更新日期：2020-02-05 00:00:00

abstract：:We have shown previously that activin A increases the number of immunoreactive follicle-stimulating hormone (FSH) cells. To further investigate the action of activin A, we examined its effects on anterior pituitary cells fractionated by centrifugal elutriation. Before activin A treatment, FSH cells were widely distrib...

journal_title：Molecular and cellular endocrinology

authors： Katayama T,Shiota K,Takahashi M

更新日期：1991-05-01 00:00:00

abstract：:Relaxin is a peptide hormone which consists of two polypeptide chains that are synthesized as a B-chain/C-peptide/A-chain precursor. We have used the polymerase chain reaction (PCR) to isolate and clone a relaxin-like cDNA from sheep placental RNA. This cDNA and two sheep genomic clones were characterised by nucleotid...

journal_title：Molecular and cellular endocrinology

authors： Roche PJ,Crawford RJ,Tregear GW

更新日期：1993-02-01 00:00:00

abstract：:Insulin-like growth factor binding protein-1 (IGFBP-1), secreted by fetal liver, is a key regulator of IGF-I bioavailability and fetal growth. IGFBP-1 phosphorylation decreases IGF-I bioavailability and diminishes its growth-promoting effects. Growth-restricted fetuses have decreased levels of circulating essential am...

journal_title：Molecular and cellular endocrinology

authors： Malkani N,Biggar K,Shehab MA,Li SS,Jansson T,Gupta MB

更新日期：2016-04-15 00:00:00

abstract：:The inhibins are secreted alpha:beta heterodimers of the TGF-beta superfamily that are mainly synthesized in Sertoli cells and granulosa cells, and are critical regulators of testicular and ovarian development and function. Mice homozygous for a targeted deletion of the inhibin alpha subunit gene (Inha(-/-)) develop s...

journal_title：Molecular and cellular endocrinology

authors： Nagaraja AK,Agno JE,Kumar TR,Matzuk MM

更新日期：2008-11-06 00:00:00

abstract：:In amphibians, the main role of thyroid hormones (THs) is to regulate metamorphosis; however, there is evidence that THs also affect gonadal sexual differentiation. In this study, Silurana (Xenopus) tropicalis tadpoles were exposed to triiodothyronine (T3; 0, 0.5, 5 and 50 nM), the bioactive form of THs for 48h. Real-...

journal_title：Molecular and cellular endocrinology

authors： Duarte-Guterman P,Trudeau VL

更新日期：2011-01-01 00:00:00

abstract：:The template for our understanding of the physiological role of the adrenal cortex was set by Hans Selye, who demonstrated its key involvement in the response to stress, of whatever origin, and who also introduced the terms glucocorticoid and mineralocorticoid. Despite this, from the late 1940s on there was certainly ...

journal_title：Molecular and cellular endocrinology

authors： Vinson GP

更新日期：2009-03-05 00:00:00

abstract：:Mammalian female fertility is critically dependent on timely coordinated intercellular communication between follicle cells. Gap junctions are small, membrane-bound, aqueous channels that couple adjacent cells ionically and gap junction proteins, connexin-37 (Cx37) and connexin-43 (Cx43) both participate in sustaining...

journal_title：Molecular and cellular endocrinology

authors： Teilmann SC

更新日期：2005-04-29 00:00:00

abstract：:Regulation of the ovalbumin (Ov) gene is strictly controlled by precise developmental, tissue-specific, and hormonal cues. The Ov gene is transcriptionally activated by four classes of steroid hormones: estrogens, androgens, glucocorticoids, and progestins. Although it has served as a model to study multi-hormone gene...

journal_title：Molecular and cellular endocrinology

authors： Dillner NB,Sanders MM

更新日期：2002-06-28 00:00:00

abstract：:In this study we have investigated the protein phosphorylation pattern in the membrane fraction prepared from bovine luteal cells. The phosphorylation reaction was carried out in vitro, under defined conditions, using either [gamma-32P]ATP or [gamma-35S]ATP as the phosphate donor. The results obtained show that [gamma...

journal_title：Molecular and cellular endocrinology

authors： Budnik LT,Mukhopadhyay AK

更新日期：1990-03-05 00:00:00

abstract：:Granulosa cell-derived inhibin A (a dimer of alpha- and beta A-subunits), activin A (a homodimer of beta A-subunits) and the activin-binding protein follistatin are important regulators of human ovarian steroidogenesis. We here studied how 8-bromo-cAMP (8br-cAMP), a protein kinase A activator, and 12-O-tetradecanoylph...

journal_title：Molecular and cellular endocrinology

authors： Tuuri T,Erämaa M,Van Schaik RH,Ritvos O

更新日期：1996-07-23 00:00:00

abstract：:Photo-affinity labelling of MSH receptors on tail-fin melanophores of Xenopus tadpoles with p-azidophenylalanine 13-alpha-MSH (Pap13)-alpha-MSH) or p-azidophenylacetyl-serine1-alpha-MSH ([Apac-Ser1]-alpha-MSH) resulted in a long-lasting stimulation of the melanophores which cannot be reversed despite continuous washin...

journal_title：Molecular and cellular endocrinology

authors： de Graan PN,Eberle AN,van de Veerdonk FC

更新日期：1982-05-01 00:00:00

abstract：:Thymocytes from SJL/J mice exhibit a periodicity in their response to hormonal stimulation with isoproterenol. This periodicity (5-9 days) is expressed in large changes in the intensity of the response (peak levels of intracellular cAMP which vary approximately 6-fold), and in the response pattern, i.e., in the occurr...

journal_title：Molecular and cellular endocrinology

authors： Riven-Kreitman R,Tauber-Finkelstein M,Zipori D,Shaltiel S

更新日期：1990-10-22 00:00:00

abstract：:We have designed and synthesized a biotinylated vasopressin antagonist which is a selective probe for studying the V1a subtype of vasopressin receptor. Initially we synthesized the novel vasopressin analogue d(CH2)5Tyr(Me)2LysNH2(9)AVP (ALVP). Biotinamidocaproate was subsequently coupled to the epsilon-amino group of ...

journal_title：Molecular and cellular endocrinology

authors： Howl J,Kerr ID,Chan CH,Wheatley M

更新日期：1991-05-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase type 1 (17-HSD type 1) is a steroidogenic enzyme catalyzing reversible interconversion of estradiol and estrone. 17-HSD type 1 is actively expressed in human placenta. We characterized 17-HSD type 1 expression and its regulation by basic fibroblast growth factor (bFGF) in JAR, JEG-...

journal_title：Molecular and cellular endocrinology

authors： Lewintre EJ,Orava M,Peltoketo H,Vihko R

更新日期：1994-08-01 00:00:00

abstract：:Activity of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by a negative feedback loop that dampens central drive of the axis via the actions of the secreted glucocorticoids. Conversely, under conditions of chronic stress, glucocorticoids delivered centrally increase hypothalamic paraventricular nucleus (PV...

journal_title：Molecular and cellular endocrinology

authors： Warne JP

更新日期：2009-03-05 00:00:00

abstract：:The expression of genes encoding inhibin/activin subunits and activin receptor was examined in four cultured Leydig tumor cells (MA-10, I-10, R2C, and LC-540). Inhibin alpha-subunit gene was highly expressed in Leydig tumor cell lines except LC-540. Both inhibin beta-A- and beta-B-subunit mRNAs were present in low lev...

journal_title：Molecular and cellular endocrinology

authors： Chen CL,Pignataro OP,Feng ZM

更新日期：1993-07-01 00:00:00

abstract：:The outcome and reproductive function were examined among patients with malignant ovarian germ cell tumors treated since 1980. Between 1980 and 2001, fertility-sparing surgery was performed in 26 women, 23 of whom received adjuvant chemotherapy. With a median follow-up of 66.6 months, all patients have been alive, wit...

journal_title：Molecular and cellular endocrinology

authors： Sagae S,Sasaki H,Nishioka Y,Terasawa K,Kudo R

更新日期：2003-04-28 00:00:00

abstract：:The effects of tamoxifen (Tam) and its 4-hydroxylated metabolite (OH-Tam) on the growth of two human breast cancer cell lines ( MCF7 and BT20 ) were evaluated by fluorometric DNA assay. The effects of the antiestrogens were dependent upon their concentrations and the nature of the cells. At concentrations below 4 micr...

journal_title：Molecular and cellular endocrinology

authors： Bardon S,Vignon F,Derocq D,Rochefort H

更新日期：1984-05-01 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) neurons coordinate reproduction. However, whether GnRH neurons directly sense free fatty acids (FFAs) is unknown. We investigated the individual effects of the FFAs docosahexaenoic acid (DHA), palmitate, palmitoleate, and oleate (100 μM each) on Gnrh mRNA expression in the mHypoA-...

journal_title：Molecular and cellular endocrinology

authors： Tran DQ,Ramos EH,Belsham DD

更新日期：2016-05-05 00:00:00

abstract：:The identification of estrogen-responsive genes in the heart, is necessary to understand estrogen-induced changes in cardiac function. Using Delta RNA fingerprinting, we demonstrate that a single injection of estradiol benzoate (50 microg, s.c.) revealed mRNA species that were elevated, down-regulated, or were unaffec...

journal_title：Molecular and cellular endocrinology

authors： Too CK,Giles A,Wilkinson M

更新日期：1999-04-25 00:00:00

abstract：:A cell culture line has been derived from lymphosarcoma P1798. Cells will not divide in the prescence of 10(-8) M dexamethasone. Half-maximal inhibition of proliferation occurs at about 10(-9) M. Half-maximal inhibition of [3H] thymidine incorporation occurs at somewhat higher concentrations of dexamethasone. When cel...

journal_title：Molecular and cellular endocrinology

authors： Thompson EA Jr

更新日期：1980-02-01 00:00:00

abstract：:The signal transducers and activators of transcriptions (Stats) are central mediators of cytokine responses especially in hematopoietic cells. The detailed molecular mechanisms of Stat activation, particularly the role of post-translational modifications and co-operation with cellular transcription factors are subject...

journal_title：Molecular and cellular endocrinology

authors： Beisenherz-Huss C,Mundt M,Herrala A,Vihko P,Schubert A,Groner B

更新日期：2001-10-25 00:00:00

abstract：:The role of AII receptors subtypes, AT1 and AT2, in the regulation of aldosterone secretion was studied in adrenal glomerulosa cells and membranes from rats on normal and low sodium intake, using AII receptor subtype-specific antagonists. In adrenal glomerulosa cells, more than 90% of the receptors were AT1 and there ...

journal_title：Molecular and cellular endocrinology

authors： Aguilera G

更新日期：1992-12-01 00:00:00

abstract：:The nucleotide specificity of the cyclic GMP-binding activity in a homogenate of Dictyostelium discoideum was determined by competition of cyclic GMP derivatives with [8-3H]-cyclic GMP for the binding sites. The results indicate that cyclic GMP is bound to the binding proteins by hydrogen bonds at N2H2, N1-H and/or C6...

journal_title：Molecular and cellular endocrinology

authors： van Haastert PJ,van Walsum H,van der Meer RC,Bulgakov R,Konijn TM

更新日期：1982-02-01 00:00:00

abstract：:FOXL2 is a gene encoding a forkhead transcription factor. Its mutations or misregulation have been shown to cause the blepharophimosis-ptosis-epicanthus inversus (BPES) syndrome and more recently have been associated with the development of Ovarian Granulosa Cell Tumors (OGCT). BPES is a genetic disorder involving mil...

journal_title：Molecular and cellular endocrinology

authors： Caburet S,Georges A,L'Hôte D,Todeschini AL,Benayoun BA,Veitia RA

更新日期：2012-06-05 00:00:00