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Effects of activin A on anterior pituitary cells fractionated by centrifugal elutriation.

Abstract：

:We have shown previously that activin A increases the number of immunoreactive follicle-stimulating hormone (FSH) cells. To further investigate the action of activin A, we examined its effects on anterior pituitary cells fractionated by centrifugal elutriation. Before activin A treatment, FSH cells were widely distributed among various fractions; a higher proportion of FSH cells was found in larger cell fractions (fractions 5-9), and a lower proportion in smaller cell fractions (fractions 2-4). After culture of the cells in each fraction with activin A (10 ng/ml) for 72 h, the number of FSH cells in fraction 4 only was significantly (P less than 0.05) higher by 225% than that in cells cultured without activin A. The amount of FSH secreted into the medium was minimal or undetectable in fractions 1-4. However, FSH secretion tended to be, or was significantly (P less than 0.01 in fraction 9), stimulated by activin A in fractions 5-9, in which the numbers of FSH cells were not significantly affected. These results suggest a dual mode of action of activin A on FSH: activin A increases the number of FSH cells in a specific type(s) of middle-sized cell fraction, and stimulates FSH secretion at least from larger cells without affecting the number of FSH cells.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Katayama T,Shiota K,Takahashi M

doi

10.1016/0303-7207(91)90071-y

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

167-73

issue

1-3

eissn

0303-7207

issn

1872-8057

pii

0303-7207(91)90071-Y

journal_volume

77

pub_type

杂志文章

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