Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.

abstract：:Calorie restriction (CR), which is thought to be largely dependent on the neuroendocrine system modulated by insulin/insulin-like growth factor-I (IGF-I) and leptin signaling, decreases morbidity and increases lifespan in many organisms. To elucidate whether insulin and leptin sensitivities are indispensable in the me...

journal_title：Molecular and cellular endocrinology

authors： Chiba T,Komatsu T,Nakayama M,Adachi T,Tamashiro Y,Hayashi H,Yamaza H,Higami Y,Shimokawa I

更新日期：2009-10-15 00:00:00

abstract：:Secretin and the secretin receptor have been reported to play an important role in regulating pancreatic water and bicarbonate secretion in mammals; however, little is known about their expression, structure, and biological functions in non-mammalian vertebrates including birds. In this study, the full-length cDNAs en...

journal_title：Molecular and cellular endocrinology

authors： Wang Y,Huang G,Li J,Meng F,He X,Leung FC

更新日期：2012-01-02 00:00:00

abstract：:Corticotropin (ACTH) regulates glucocorticoid production through specific receptors on the adrenal cortex. Analysis of the ACTH receptor mRNA in human adrenal has revealed the presence of five transcripts ranging from 1.8 to 11 kilobases (kb). Characterization of the 5'-untranslated regions (UTRs) of the ACTH receptor...

journal_title：Molecular and cellular endocrinology

authors： Naville D,Barjhoux L,Jaillard C,Lebrethon MC,Saez JM,Bégeot M

更新日期：1994-12-01 00:00:00

abstract：:The higher prevalence of thyroid disease in women suggests that estrogen (E2) might be involved in the pathophysiology of thyroid dysfunction. To approach the question of the effect of stromal cells in the modulation of thyroid epithelial cells activity, we established and characterized a homogeneous stromal cell popu...

journal_title：Molecular and cellular endocrinology

authors： Gantus MA,Alves LM,Stipursky J,Souza EC,Teodoro AJ,Alves TR,Carvalho DP,Martinez AM,Gomes FC,Nasciutti LE

更新日期：2011-04-30 00:00:00

abstract：:Although well-established, the underlying mechanisms involved in obesity-related plasma adiponectin decline remain elusive. Oxidative stress is associated with obesity and insulin resistance and considered to contribute to the progression toward obesity-related metabolic disorders. In this study, we investigated the e...

journal_title：Molecular and cellular endocrinology

authors： Wang Z,Dou X,Gu D,Shen C,Yao T,Nguyen V,Braunschweig C,Song Z

更新日期：2012-02-26 00:00:00

abstract：:To elucidate the cellular origin of interleukin-1 (IL-1) in the mammalian testis, we assayed IL-1 activity in culture media of Sertoli cells collected from rats at 20, 35 and 45 days of age as well as in culture media of interstitial, peritubular and germ cells from adult rats. IL-1 was detected in Sertoli cell cultur...

journal_title：Molecular and cellular endocrinology

authors： Gérard N,Syed V,Bardin W,Genetet N,Jégou B

更新日期：1991-11-01 00:00:00

abstract：:Advanced prostate cancers, initially sensitive to androgen deprivation therapy, frequently progress to the castration-resistant prostate cancer phenotype (CRPC) through mechanisms not yet fully understood. In this study we investigated mitochondrial involvement in the establishment of refractoriness to hormone therapy...

journal_title：Molecular and cellular endocrinology

authors： Pignatta S,Arienti C,Zoli W,Di Donato M,Castoria G,Gabucci E,Casadio V,Falconi M,De Giorgi U,Silvestrini R,Tesei A

更新日期：2014-01-25 00:00:00

abstract：:Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin. Partial proteolysis of androgen-bound receptor protein resulted in a 29-kDa proteolysis-resisting fragment, whereas antiandrogen binding stabilised a 35-k...

journal_title：Molecular and cellular endocrinology

authors： Kuil CW,Mulder E

更新日期：1994-06-01 00:00:00

abstract：:Two adenosine receptors A1 and A2 are associated with either stimulation (A2) or inhibition (A1) of adenylate cyclase. Using the clonal cell line Ob1771, we have studied the expression of the two receptors during the process of adipose conversion accelerated by exposure to dexamethasone and 3-isobutyl-l-methylxanthine...

journal_title：Molecular and cellular endocrinology

authors： Børglum JD,Vassaux G,Richelsen B,Gaillard D,Darimont C,Ailhaud G,Négrel R

更新日期：1996-03-01 00:00:00

abstract：:Five overlapping synthetic peptides representing two regions of thyrotropin (TSH) binding sites of human thyrotropin receptor (TSHR) (peptides 12-30, 24-44, 308-328, 324-344 and 339-364) were investigated for their ability to cause proliferation of peripheral blood lymphocytes (PBL) from eight patients with Graves' di...

journal_title：Molecular and cellular endocrinology

authors： Sakata S,Tanaka S,Okuda K,Miura K,Manshouri T,Atassi MZ

更新日期：1993-03-01 00:00:00

abstract：:South African Angora goats are susceptible to cold stress, due to their inability to produce sufficient levels of cortisol. During adrenal steroidogenesis the production of cortisol relies on the activity of two key enzymes, namely cytochrome P450 17alpha-hydroxylase and 3beta-hydroxysteroid dehydrogenase. Cytochrome ...

journal_title：Molecular and cellular endocrinology

authors： Goosen P,Swart AC,Storbeck KH,Swart P

更新日期：2010-02-05 00:00:00

abstract：:Stanniocalcin (STC) (formerly known as both teleocalcin and hypocalcin) is an anti-hypercalcemic, glycoprotein hormone that is produced by the corpuscles of Stannius (CS), endocrine glands that are confined to bony fishes. The hormone has a unique amino acid sequence and exists as a disulfide-linked homodimer in the n...

journal_title：Molecular and cellular endocrinology

authors： Wagner GF,Dimattia GE,Davie JR,Copp DH,Friesen HG

更新日期：1992-12-01 00:00:00

abstract：:During rapid development of the fetus, levels of high density lipoprotein (HDL) are elevated in pregnant women. The receptor for HDL, scavenger receptor class B type I (SR-BI), mediates selective cholesteryl ester uptake and is highly expressed in the human placenta. Because of the rapid growth of uterus during early ...

journal_title：Molecular and cellular endocrinology

authors： Kim JG,Vallet JL,Nonneman D,Christenson RK

更新日期：2004-07-30 00:00:00

abstract：:One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are on...

journal_title：Molecular and cellular endocrinology

authors： Gaujoux S,Chanson P,Bertherat J,Sauvanet A,Ruszniewski P

更新日期：2014-01-25 00:00:00

abstract：:The heterodimeric 'pregnancy-specific' hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the beta-chain expressed in the absence of alpha-chain, is aberrantly expressed in a number of different tumors ...

journal_title：Molecular and cellular endocrinology

authors： Delves PJ,Iles RK,Roitt IM,Lund T

更新日期：2007-01-02 00:00:00

abstract：:The metabolism of progesterone (PROG) by cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17α-hydroxyprogesterone (17-OHPROG) and 16α-hydroxyprogesterone (16-OHPROG) in humans. Unlike 17-OHPROG, 16-OHPROG is not metabolised further in steroidogenic tissue. While this metabolite ca...

journal_title：Molecular and cellular endocrinology

authors： Storbeck KH,Swart P,Africander D,Conradie R,Louw R,Swart AC

更新日期：2011-04-10 00:00:00

abstract：:Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroe...

journal_title：Molecular and cellular endocrinology

authors： Vandenput L,Ohlsson C

更新日期：2014-01-25 00:00:00

abstract：:The defining characteristic of obesity is increased adipose tissue (AT) mass following chronic positive energy supply. AT mass is determined by adipocyte number and size, which reflect proliferation and differentiation of preadipocytes and hypertrophy of pre-existing adipocytes. The molecular pathways governing AT exp...

journal_title：Molecular and cellular endocrinology

authors： Hutley LJ,Newell FS,Kim YH,Luo X,Widberg CH,Shurety W,Prins JB,Whitehead JP

更新日期：2011-06-06 00:00:00

abstract：:Recent evidence suggests that lymphocytes produce prolactin (PRL). Here, we report the cDNA cloning and expression of PRL from normal human thymocytes. Sequence analysis showed that the thymocyte cDNA encodes a 23 kDa protein which is identical to pituitary PRL. RNA blot analysis showed that the thymocyte PRL mRNA is ...

journal_title：Molecular and cellular endocrinology

authors： O'Neal KD,Montgomery DW,Truong TM,Yu-Lee LY

更新日期：1992-09-01 00:00:00

abstract：:Transcription elongation of many eukaryotic genes is regulated. Two negative transcription elongation factors, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) are known to stall collaboratively RNA polymerase II promoter proximally. We dis...

journal_title：Molecular and cellular endocrinology

authors： Fujita T,Piuz I,Schlegel W

更新日期：2010-05-05 00:00:00

abstract：:Oleic (OA) and linoleic (LA) fatty acids may be important regulators of Slc2a4 gene (GLUT4 protein) in skeletal muscle, thus participating in insulin resistance. We investigated the effect of OA and LA on the Slc2a4/GLUT4 expression in L6 muscle cells; as well as potential transcriptional regulators. OA and LA (50-400...

journal_title：Molecular and cellular endocrinology

authors： Poletto AC,Furuya DT,David-Silva A,Ebersbach-Silva P,Santos CL,Corrêa-Giannella ML,Passarelli M,Machado UF

更新日期：2015-02-05 00:00:00

abstract：:Diabetes exacerbates neuronal injury mediated through neurotransmitters deregulation in cerebral cortex. Our study analyzed the neuroprotective effect of curcumin to prevent cortical dysfunction associated with diabetes. Our study revealed decreased gene expression of muscarinic M1, insulin receptor, SOD, choline acet...

journal_title：Molecular and cellular endocrinology

authors： Peeyush Kumar T,Antony S,Soman S,Kuruvilla KP,George N,Paulose CS

更新日期：2011-01-01 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) protects the non-discriminating mineralocorticoid receptor from occupation by glucocorticoids. In man the enzyme is also highly expressed in the placenta where it is thought to also protect the fetus from the high circulating levels of maternal glu...

journal_title：Molecular and cellular endocrinology

authors： Li KX,Smith RE,Ferrari P,Funder JW,Krozowski ZS

更新日期：1996-06-18 00:00:00

abstract：:The addition of glucose to suspensions of HIT-T15 insulinoma cells caused a small, transient acidification followed by a gradual, progressive alkalinisation, as assessed by the fluorescent pH-sensitive dye 2',7'-biscarboxyethyl-5'-(6')-carboxyfluorescein (BCECF). Treatment of cells with acetate or lactate produced an ...

journal_title：Molecular and cellular endocrinology

authors： Trebilcock R,Lynch A,Tomlinson S,Best L

更新日期：1990-05-28 00:00:00

abstract：:NPS(o-nitrophenyl sulfenyl)-ACTH stimulated steroidogenesis in Y1 cells to the same maximum level as did ACTH, but with a 60-fold lower potency than the native hormone. NPS-ACTH also stimulated the extracellular accumulation of cAMP in Y1 cells with lower potency than the unmodified hormone. The amount of cAMP accumul...

journal_title：Molecular and cellular endocrinology

authors： Rae PA,Zinman H,Ramachandran J,Schimmer BP

更新日期：1980-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) is expressed in adipose tissue and is involved in adipocyte metabolism. Although NPY impacts on glucose utilization in vivo, the underlying cellular mechanism is yet to be fully elucidated. In this study we investigated the effect of NPY on the insulin-stimulated translocation of glucose transport...

journal_title：Molecular and cellular endocrinology

authors： Gericke MT,Schröder T,Kosacka J,Nowicki M,Klöting N,Spanel-Borowski K

更新日期：2012-01-02 00:00:00

abstract：:A large part of germ cells die apoptotically during testicular development in rodents. In the present study, a wave of germ cell apoptosis was observed between days 10 and 30 of postnatal life by in situ 3'-end labeling and DNA fragmentation analysis. To explore the potential involvement of Bcl-2 family members in thi...

journal_title：Molecular and cellular endocrinology

authors： Yan W,Suominen J,Samson M,Jégou B,Toppari J

更新日期：2000-07-25 00:00:00

abstract：INTRODUCTION:Iron overload leads to multiple organ damage including endocrine organ dysfunctions. Hypogonadism is the most common non-diabetic endocrinopathy in primary and secondary iron overload syndromes. AIM:To explore the molecular determinants of iron overload-induced hypogonadism with specific focus on hypothal...

journal_title：Molecular and cellular endocrinology

authors： Macchi C,Steffani L,Oleari R,Lettieri A,Valenti L,Dongiovanni P,Romero-Ruiz A,Tena-Sempere M,Cariboni A,Magni P,Ruscica M

更新日期：2017-10-15 00:00:00

abstract：:FOXL2 is a gene encoding a forkhead transcription factor. Its mutations or misregulation have been shown to cause the blepharophimosis-ptosis-epicanthus inversus (BPES) syndrome and more recently have been associated with the development of Ovarian Granulosa Cell Tumors (OGCT). BPES is a genetic disorder involving mil...

journal_title：Molecular and cellular endocrinology

authors： Caburet S,Georges A,L'Hôte D,Todeschini AL,Benayoun BA,Veitia RA

更新日期：2012-06-05 00:00:00

abstract：:Estrogens are the primary female sex hormones and play important roles in both reproductive and non-reproductive systems. Estrogens can be synthesized in non-reproductive tissues such as liver, heart, muscle, bone and the brain. During the past decade, increasing evidence suggests that brain estrogen can not only be s...

journal_title：Molecular and cellular endocrinology

authors： Li R,Cui J,Shen Y

更新日期：2014-05-25 00:00:00