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Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice.

Abstract：

:Di-n-Butyl (DBP) and Di-(2-EthylHexyl) (DEHP) phthalates can leach from daily-use products resulting in environmental exposure. In male rodents, phthalate exposure results in reproductive effects. To evaluate effects on the immature primate testis, testis fragments from 6-month-old rhesus macaques were grafted subcutaneously to immune-deficient mice, which were exposed to 0, 10, or 500 mg/kg of DBP or DEHP for 14 weeks or 28 weeks (DBP only). DBP exposure reduced the expression of key steroidogenic genes, indicating that Leydig cell function was compromised. Exposure to 500 mg/kg impaired tubule formation and germ cell differentiation and reduced numbers of spermatogonia. Exposure to 10 mg/kg did not affect development, but reduced Sertoli cell number and resulted in increased expression of inhibin B. Exposure to DEHP for 14 week also affected steroidogenic genes expression. Therefore, long-term exposure to phthalate esters affected development and function of the primate testis in a time and dosage dependent manner.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Rodriguez-Sosa JR,Bondareva A,Tang L,Avelar GF,Coyle KM,Modelski M,Alpaugh W,Conley A,Wynne-Edwards K,França LR,Meyers S,Dobrinski I

doi

10.1016/j.mce.2014.10.004

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

89-100

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(14)00315-3

journal_volume

398

pub_type

杂志文章

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