Abstract：
:Fibrosis is one of the key pathological features of airway remodeling in asthma. In the normal airway the amount of collagen and other extracellular matrix components is kept in equilibrium by regulation of synthesis and degradation. In asthma this homeostasis is disrupted due to genetic and environmental factors. In the airways of patients with the disease there is increased extracellular matrix deposition, particularly in the reticular basement membrane region, lamina propria and submucosa. Fibrosis is important as it can occur early in the pathogenesis of asthma, be associated with severity and resistant to therapy. In this review we will discuss current knowledge of relaxin and other key regulators of fibrosis in the airway including TGFβ, Smad2/3 and matrix metalloproteinases. As fibrosis is not directly targeted or effectively treated by current asthma drugs including corticosteroids, characterization of airway fibrosis and how it is regulated will be essential for the development of novel therapies for asthma.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Royce SG,Cheng V,Samuel CS,Tang MLdoi
10.1016/j.mce.2012.01.007subject
Has Abstractpub_date
2012-04-04 00:00:00pages
167-75issue
2eissn
0303-7207issn
1872-8057pii
S0303-7207(12)00011-1journal_volume
351pub_type
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