Measurement of inhibin A and activin A in pregnancy--possible diagnostic applications.

abstract：:The immune system and the neuroendocrine system are functionally interactive. Lymphocytes possess opioid receptors as well as growth hormone receptors (GHR) by which opioids and growth hormone (GH) may modulate immune functions. In this study, we have investigated the effects of morphine on [125I]hGH binding and GHR g...

journal_title：Molecular and cellular endocrinology

authors： Henrohn D,Le Grevés P,Nyberg F

更新日期：1997-12-12 00:00:00

abstract：:Allatostatins, peptides with an YXFGL-amide C-terminus, cause a rapid and reversible inhibition of the sesquiterpenoid juvenile hormone III biosynthesis by cockroach corpora allata in vitro. Inhibition is relieved by farnesol and by mevalonate, and neither HMG-CoA reductase nor HMG-CoA synthesis (HMG-CoA synthase and ...

journal_title：Molecular and cellular endocrinology

authors： Sutherland TD,Feyereisen R

更新日期：1996-07-01 00:00:00

abstract：:Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a fundamental role in endocrine pancreatic function. In the present study expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined together with the effects of both major circula...

journal_title：Molecular and cellular endocrinology

authors： Khan D,Vasu S,Moffett RC,Irwin N,Flatt PR

更新日期：2016-11-15 00:00:00

abstract：:Local mediator prostaglandins and bradykinin are involved in inflammation and pain. We explored bradykinin effects on prostaglandin E2 (PGE2) release from fibroblasts derived from human skeletal muscular biopsies. Bradykinin induced PGE2 release through bradykinin B2 receptors, since PGE2 release was blocked by the br...

journal_title：Molecular and cellular endocrinology

authors： Muscella A,Cossa LG,Vetrugno C,Marsigliante S

更新日期：2020-05-01 00:00:00

abstract：:Insulin-induced glucose uptake by skeletal muscle results from Akt2 activation and is severely impaired during insulin resistance. Recently, we and others have demonstrated that BMP9 improves glucose homeostasis in diabetic and non-diabetic rodents. However, the mechanism by which BMP9 modulates insulin action remains...

journal_title：Molecular and cellular endocrinology

authors： Anhê FF,Lellis-Santos C,Leite AR,Hirabara SM,Boschero AC,Curi R,Anhê GF,Bordin S

更新日期：2010-05-05 00:00:00

abstract：:Osterix, a zinc-finger transcription factor, is required for osteoblast differentiation and new bone formation during embryonic development. The c-Src of tyrosine kinase is involved in a variety of cellular signaling pathways, leading to the induction of DNA synthesis, cell proliferation, and cytoskeletal reorganizati...

journal_title：Molecular and cellular endocrinology

authors： Choi YH,Han Y,Lee SH,Cheong H,Chun KH,Yeo CY,Lee KY

更新日期：2015-05-15 00:00:00

abstract：:A central question in glucocorticoid mechanism of action via the glucocorticoid receptor (GR) is what determines ligand-selective transcriptional responses. Using a panel of 12 GR ligands, we show that the extent of GR phosphorylation at S226 and S211, GR half-life and transcriptional response, occur in a ligand-selec...

journal_title：Molecular and cellular endocrinology

authors： Avenant C,Ronacher K,Stubsrud E,Louw A,Hapgood JP

更新日期：2010-10-07 00:00:00

abstract：:The function of the major adrenal steroid dehydroepiandrosterone (DHEA) is not known. It has been reported to improve learning and memory in mice and can exert neuroprotective and trophic effects, particularly in the hippocampus. We recently described a cytochrome P450 (Cyp7b), that catalyses the 7alpha-hydroxylation ...

journal_title：Molecular and cellular endocrinology

authors： Bean R,Seckl JR,Lathe R,Martin C

更新日期：2001-03-28 00:00:00

abstract：:Thyroid hormone pretreatment was indicated to increase tissue tolerance to ischemia-reperfusion injury (IRI) in various organs, but the underlying molecular mechanisms remains largely unknown. Induction of heme oxygenase-1 (HO-1) protects organs against IRI. The present study investigated the effect of thyroid hormone...

journal_title：Molecular and cellular endocrinology

authors： Li F,Lu S,Zhu R,Zhou Z,Ma L,Cai L,Liu Z

更新日期：2011-06-06 00:00:00

abstract：:When measured in vitro using human placental microsomal preparations, the aromatization of 16alpha-hydroxytestosterone to estriol and androstenedione to estrone and estradiol proceeds at almost identical initial rates. Important differences between 16alpha-hydroxytestosterone and adrostenedione aromatization are evide...

journal_title：Molecular and cellular endocrinology

authors： Canick JA,Ryan KJ

更新日期：1976-12-01 00:00:00

abstract：:17Beta hydroxysteroid dehydrogenase type 7 (HSD17B7) was described to possess dual functionality in steroidogenesis as well as in postsqualene cholesterol biosynthesis in vitro. In order to gain insight into the transcriptional regulation, and thereby into in vivo functionality of HSD17B7, we analyzed and compared the...

journal_title：Molecular and cellular endocrinology

authors： Ohnesorg T,Adamski J

更新日期：2006-03-27 00:00:00

abstract：:Trophoblast cells produce several inmmuneregulators like the Vasoactive Intestinal Peptide (VIP) and P4 targeting multiple circuits, and also display an intese phagocytic ability allowing embryo implantation in a tolerogenic context. Here, we explored whether P4 and VIP- crosstalk modulates trophoblast cell function, ...

journal_title：Molecular and cellular endocrinology

authors： Vota D,Aguero M,Grasso E,Hauk V,Gallino L,Soczewski E,Pérez Leirós C,Ramhorst R

更新日期：2017-03-05 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease resulting from the loss of pancreatic β cells and subsequent insulin production. Novel interventional therapies are urgently needed that can protect existing β cells from cytokine-induced death and enhance their function before symptomatic onset. Our initial evidence is s...

journal_title：Molecular and cellular endocrinology

authors： Sharp-Tawfik AE,Coiner AM,MarElia CB,Kazantzis M,Zhang C,Burkhardt BR

更新日期：2019-08-20 00:00:00

abstract：:The effects of glucocorticoids on expression of the beta1-adrenergic receptor (beta1AR) gene have been varied. To study the mechanism underling hormonal regulation of the beta1AR, transient transfection of progressively deleted ovine beta1AR promoter fragments was used to identify a 43-bp region (-1274 to -1232 from t...

journal_title：Molecular and cellular endocrinology

authors： Tseng YT,Stabila JP,Nguyen TT,McGonnigal BG,Waschek JA,Padbury JF

更新日期：2001-07-05 00:00:00

abstract：:Steroids are synthesized from the adrenal glands and gonads by enzymes of the cytochromes P450 and hydroxysteroid dehydrogenase in nature. These enzymes are located in the membrane of endoplasmic reticulum and mitochondria to catalyze redox reactions using electrons transported from the membrane. In the mitochondria, ...

journal_title：Molecular and cellular endocrinology

authors： Chien Y,Rosal K,Chung BC

更新日期：2017-02-05 00:00:00

abstract：:Studies were conducted in vitro and in vivo to determine whether or not inhibin affects the transcription rate of the gene for the beta subunit of follicle stimulating hormone (FSH beta). Pituitary cells in primary culture were incubated with 0-3000 milli-units/ml inhibin; a dose-related decrement in mRNA was obtained...

journal_title：Molecular and cellular endocrinology

authors： Clarke IJ,Rao A,Fallest PC,Shupnik MA

更新日期：1993-02-01 00:00:00

abstract：:The thyroid hormone receptors (TR) are able to bind DNA and to repress transcription in the absence of thyroid hormone. This repression function is an important feature of TRs as aberrant silencing can lead to severe diseases and developmental abnormalities. TR utilizes different mechanisms to achieve repression of ta...

journal_title：Molecular and cellular endocrinology

authors： Eckey M,Moehren U,Baniahmad A

更新日期：2003-12-31 00:00:00

abstract：:Serine/threonine protein phosphatase 2A (PP2A) regulates diverse physiological processes such as cell cycle, growth, apoptosis, and signal transduction. Previously, we demonstrated that silencing of the α-isoform of PP2A catalytic subunit (PP2A Cα) in osteoblasts accelerated osteoblast differentiation, whereas its ove...

journal_title：Molecular and cellular endocrinology

authors： Yoshida K,Teramachi J,Uchibe K,Ikegame M,Qiu L,Yang D,Okamura H

更新日期：2018-07-15 00:00:00

abstract：:Mammalian spermatozoa undergo several signaling and biochemical transformations in the female genital tract, collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, where it undergoes the acrosome reaction (AR), a process enabling it to penetrate and fertilize the egg. Actin pol...

journal_title：Molecular and cellular endocrinology

authors： Breitbart H,Rotman T,Rubinstein S,Etkovitz N

更新日期：2010-01-27 00:00:00

abstract：:Prolactin (PRL) modulates proliferation in the mammary gland and other tissues, in part through inducing transcription of cyclin D1, a key regulator of G(1) phase cell cycle progression. We showed previously that PRL, via Jak2, induces binding of Stat5 to a distal GAS site (GAS1) in the cyclin D1 promoter. However, fu...

journal_title：Molecular and cellular endocrinology

authors： Brockman JL,Schuler LA

更新日期：2005-07-15 00:00:00

abstract：:Various water-insoluble cannabinoids as well as SP-111A, the water-soluble derivative of delta 9-tetrahydrocannabinol (delta 9-THC), reduced hCG and dibutyryl-cAMP stimulated testosterone production by rat testicular Leydig cell preparations. With 0.15 microM (0.05 micrograms/ml) 8-beta-OH-delta 9-THC the inhibition w...

journal_title：Molecular and cellular endocrinology

authors： Jakubovic A,McGeer EG,McGeer PL

更新日期：1979-07-01 00:00:00

abstract：:Dopamine and somatostatin are both involved in the negative control of normal pituitary cells. Dopamine subtype 2 receptor (D2DR) and somatostatin receptor (sst) agonists, mainly directed to sst2, are used in the treatment of pituitary adenomas. Nevertheless, a majority of corticotroph and gonadotroph adenomas and a t...

journal_title：Molecular and cellular endocrinology

authors： Saveanu A,Jaquet P,Brue T,Barlier A

更新日期：2008-05-14 00:00:00

abstract：:The testicular Sertoli cell produces an extracellular androgen-binding protein (ABP) that binds testosterone and dihydrotestosterone with high affinity. The ABP gene also encodes plasma sex hormone-binding globulin (SHBG), which is produced by the liver of most species. Unlike the human, adult rats and mice do not exp...

journal_title：Molecular and cellular endocrinology

authors： Reventos J,Sullivan PM,Joseph DR,Gordon JW

更新日期：1993-10-01 00:00:00

abstract：:Oxytocin receptors (OT-R) are known to be involved in the course of labor since a massive increase in OT-binding sites is observed in the uterus just before parturition. Vasopressin (AVP)-binding sites have also been observed and have been shown to mediate uterotonic responses. To determine exactly which subtypes of O...

journal_title：Molecular and cellular endocrinology

authors： Clerget MS,Elalouf JM,Germain G

更新日期：1997-12-31 00:00:00

abstract：:The mitogenic and metabolic activities of insulin-like growth factors (IGF) are modulated by a family of six high affinity IGF binding proteins (IGFBPs). This study describes the expression of the mouse IGFBP-6 which is unique among IGFBPs in its preferential binding of IGF II, in insect cells using the baculovirus sy...

journal_title：Molecular and cellular endocrinology

authors： Putzer P,Breuer P,Götz W,Gross M,Kübler B,Scharf JG,Schuller AG,Hartmann H,Braulke T

更新日期：1998-02-01 00:00:00

abstract：:All organisms need to be capable of adapting to changes in the availability and composition of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet could significantly extend the lifespan of rats, and since then a CR diet has been shown to increase lifespan and healthspan in model o...

journal_title：Molecular and cellular endocrinology

authors： Cummings NE,Lamming DW

更新日期：2017-11-05 00:00:00

abstract：:There are multiple systems for cellular cholesterol delivery for steroidogenesis, including uptake of lipoprotein-derived cholesterol via LDL receptor mediated endocytic pathways and SR-BI mediated "selective" pathways, as well as from endogenous cholesterol synthesis and the mobilization of stored cholesteryl esters....

journal_title：Molecular and cellular endocrinology

authors： Kraemer FB

更新日期：2007-02-01 00:00:00

abstract：:Knowledge of the mechanisms of single dominant follicle selection has led to the development of a novel and effective ovulation induction regimen for anovulatory women; the step down protocol. This commences with a fixed high gonadotropin dose followed by several decremental steps. For some patients the initial dose i...

journal_title：Molecular and cellular endocrinology

authors： Macklon NS,Fauser BC

更新日期：2002-01-25 00:00:00

abstract：:Growth hormone (GH) secretion, evoked by either pituitary adenylate cyclase-activating polypeptide (PACAP) or dopamine (DA), is dependent on both voltage-sensitive calcium channels (VSCC) and cAMP signaling in goldfish. We further characterized the involvement of Ca2+ in evoked release by PACAP and DA, by examining th...

journal_title：Molecular and cellular endocrinology

authors： Chang JP,Wong CJ,Davis PJ,Soetaert B,Fedorow C,Sawisky G

更新日期：2003-08-29 00:00:00

abstract：:G-protein-coupled estrogen receptor-30 (GPR30), also known as G-protein estrogen receptor-1 (GPER1), is a putative extranuclear estrogen receptor whose precise functions in the brain are poorly understood. Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective ro...

journal_title：Molecular and cellular endocrinology

authors： Tang H,Zhang Q,Yang L,Dong Y,Khan M,Yang F,Brann DW,Wang R

更新日期：2014-04-25 00:00:00