当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > New insights into the classical and non-classical actions of estrogen: evidence from estrogen receptor knock-out and knock-in mice.

New insights into the classical and non-classical actions of estrogen: evidence from estrogen receptor knock-out and knock-in mice.

Abstract：

:Estrogen receptor alpha (ERalpha) mediates estrogen (E2) actions in the brain and is critical for normal reproductive function and behavior. In the classical pathway, ERalpha binds to estrogen response elements (EREs) to regulate gene transcription. ERalpha can also participate in several non-classical pathways, including ERE-independent gene transcription via protein-protein interactions with transcription factors and rapid, non-genotropic pathways. To distinguish between ERE-dependent and ERE-independent mechanisms of E2 action in vivo, we have created ERalpha null mice that possess an ER knock-in mutation (E207A/G208A; "AA"), in which the mutant ERalpha cannot bind to DNA but retains activity in ERE-independent pathways (ERalpha(-/AA) mice). Understanding the molecular mechanisms of ERalpha action will be helpful in developing pharmacological therapies that differentiate between ERE-dependent and ERE-independent processes. This review focuses on how the ERalpha(-/AA) model has contributed to our knowledge of ERalpha signaling mechanisms in estrogen regulation of the reproductive axis and sexual behavior.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

McDevitt MA,Glidewell-Kenney C,Jimenez MA,Ahearn PC,Weiss J,Jameson JL,Levine JE

doi

10.1016/j.mce.2008.04.003

subject

Has Abstract

pub_date

2008-08-13 00:00:00

pages

24-30

issue

1-2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(08)00130-5

journal_volume

290

pub_type

杂志文章,评审

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • A monoclonal antibody which inhibits the biological activity of rat prolactin, but not prolactin from other species.

    abstract：:Monoclonal antibodies generated to ovine prolactin were screened for their ability to neutralize the biological activity of prolactin from several species. By Western blot analysis, antibody 6F11 cross-reacted strongly with prolactin in homogenates of anterior pituitary glands from squirrel monkey, sheep and rat. In a...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(90)90249-8

    authors： Scammell JG,Wear LB,Von Haven R

    更新日期：1990-06-18 00:00:00

  • Calcium-dependent action of hypertrehalosemic hormone on activation of glycogen phosphorylase in cockroach fat body.

    abstract：:Signaling mechanisms for Blaberus discoidalis hypertrehalosemic hormone (Bld-HrTH)-dependent glycogen phosphorylase activation were investigated in vitro using fat body of the tropical cockroach, B. discoidalis. Brief treatment of fat bodies with Bld-HrTH in the absence of extracellular Ca2+ showed a significant activ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(95)03715-2

    authors： Park JH,Keeley LL

    更新日期：1996-02-05 00:00:00

  • Heme oxygenase-1 is induced by thyroid hormone and involved in thyroid hormone preconditioning-induced protection against renal warm ischemia in rat.

    abstract：:Thyroid hormone pretreatment was indicated to increase tissue tolerance to ischemia-reperfusion injury (IRI) in various organs, but the underlying molecular mechanisms remains largely unknown. Induction of heme oxygenase-1 (HO-1) protects organs against IRI. The present study investigated the effect of thyroid hormone...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.03.019

    authors： Li F,Lu S,Zhu R,Zhou Z,Ma L,Cai L,Liu Z

    更新日期：2011-06-06 00:00:00

  • Estradiol inhibits growth hormone receptor gene expression in rabbit liver.

    abstract：:We studied the ontogeny of GH receptor mRNA levels and the effect of exogenous estradiol administration on GH receptor mRNA levels in rabbit liver. A solution hybridization-RNase protection assay revealed a predominant 370-base long protected band corresponding to the mRNA encoding the transmembrane GH receptor, and a...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(94)90072-8

    authors： Domené HM,Marín G,Sztein J,Yu YM,Baron J,Cassorla FG

    更新日期：1994-07-01 00:00:00

  • Interactions between activin and follicle-stimulating hormone-suppressing protein and their mechanisms of action on cultured rat granulosa cells.

    abstract：:Direct roles of follicle-stimulating hormone (FSH)-suppressing protein (FSP) and activin in regulation of ovarian granulosa cell differentiation have been reported recently. The present study further investigated the effects of these peptides on steroidogenesis and inhibin production as well as cAMP generation in cult...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(91)90100-7

    authors： Xiao S,Findlay JK

    更新日期：1991-08-01 00:00:00

  • Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin.

    abstract：:Sex steroids have been known to play important roles in the homeostasis of human skin, but little is known about their biosyntheses in that tissue. In this study, we characterized the correlation between the concentrations of sex steroids and the expression levels of the factors involved in their synthesis or metaboli...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2012.05.005

    authors： Inoue T,Miki Y,Abe K,Hatori M,Hosaka M,Kariya Y,Kakuo S,Fujimura T,Hachiya A,Honma S,Aiba S,Sasano H

    更新日期：2012-10-15 00:00:00

  • Ovarian follicle populations of the rat express TGF-beta signalling pathways.

    abstract：:The transforming growth factor-beta (TGF-beta) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which whe...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(03)00062-5

    authors： Drummond AE,Dyson M,Le MT,Ethier JF,Findlay JK

    更新日期：2003-04-28 00:00:00

  • Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations.

    abstract：:Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism (CH), a relatively frequent endocrine disease in newborns (1 in 3000-4000 live births). TD is a defect in the organogenesis of the gland resulting in hypoplastic, ectopic or absent-thyroid gland. TD is usually sporadic but mutations in trans...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2010.03.009

    authors： Montanelli L,Tonacchera M

    更新日期：2010-06-30 00:00:00

  • Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models.

    abstract：:The anterior pituitary gland is a key organ involved in the control of multiple physiological functions including growth, reproduction, metabolism and stress. These functions are controlled by five distinct hormone-producing pituitary cell types that produce growth hormone (somatotropes), prolactin (lactotropes), adre...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2017.12.007

    authors： Vázquez-Borrego MC,Gahete MD,Martínez-Fuentes AJ,Fuentes-Fayos AC,Castaño JP,Kineman RD,Luque RM

    更新日期：2018-03-05 00:00:00

  • The steroidogenic effect of single-chain bovine LH analogs in cultured bovine follicular cells.

    abstract：:Single-chain gonadotropin analogs had been constructed for the purpose of structure-function studies and analog design. Incorporation of a spacer derived from the carboxyl terminal peptide (CTP) of the choriogonadotropin (CG) beta subunit between the tethered subunit domains of the human gonadotropins is beneficial fo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.03.011

    authors： Braw-Tal R,Pen S,Grinberg M,Nakav S,Ben-Menahem D

    更新日期：2006-06-27 00:00:00

  • Role of metal ions in ligand-receptor interaction: insights from structural studies.

    abstract：:Experimental data indicate that metal ions such as Na(+), Ca(2+) and Mg(2+), which are present in millimolar concentrations in the extracellular environment, modulate binding of ligands to plasma membrane receptors. Here, we briefly review structural studies that demonstrate that various types of ligands, including pe...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2005.11.023

    authors： Ananthanarayanan VS,Kerman A

    更新日期：2006-02-26 00:00:00

  • Binding kinetics of ligands acting at GPCRs.

    abstract：:The influence of drug-receptor binding kinetics has often been overlooked during the development of new therapeutics that target G protein-coupled receptors (GPCRs). Over the last decade there has been a growing understanding that an in-depth knowledge of binding kinetics at GPCRs is required to successfully target th...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2019.01.018

    authors： Sykes DA,Stoddart LA,Kilpatrick LE,Hill SJ

    更新日期：2019-04-05 00:00:00

  • Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms.

    abstract：:People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of fat cell developme...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2016.11.011

    authors： Chen SC,Brooks R,Houskeeper J,Bremner SK,Dunlop J,Viollet B,Logan PJ,Salt IP,Ahmed SF,Yarwood SJ

    更新日期：2017-01-15 00:00:00

  • Mesenchymal stem cell (MSC)-mediated survival of insulin producing pancreatic β-cells during cellular stress involves signalling via Akt and ERK1/2.

    abstract：:Mesenchymal stem cells (MSC) are of interest for cell therapy since their secreted factors mediate immunomodulation and support tissue regeneration. This study investigated the direct humoral interactions between MSC and pancreatic β-cells using human telomerase-immortalized MSC (hMSC-TERT) and rat insulinoma-derived ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2018.01.024

    authors： Liu C,Zhang W,Peradze N,Lang L,Straetener J,Feilen PJ,Alt M,Jäger C,Laubner K,Perakakis N,Seufert J,Päth G

    更新日期：2018-09-15 00:00:00

  • The modulation of placental lactogen release by opioids: a role for extracellular calcium.

    abstract：:We previously reported that kappa opioids stimulated the release of human placental lactogen (hPL) from trophoblastic cells and that this effect was prevented by co-incubation with naloxone. We also reported that adenylate cyclase was not directly involved in this process. In order to understand the post-receptor even...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(93)90148-d

    authors： Petit A,Gallo-Payet N,Bellabarba D,Lehoux JG,Bélisle S

    更新日期：1993-01-01 00:00:00

  • Inhibition of FSH action on granulosa cells by low molecular weight components of follicular fluid.

    abstract：:Immature female rats were injected with a single dose (10 IU) of pregnant mare serum gonadotropin to induce growth and maturation of ovarian follicles. Using such ovaries as a model, we tested the effects of low molecular weight subfractions of charcoal-absorbed bovine follicular fluid (FF-c) on (a) radioiodinated hum...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(82)90086-7

    authors： Fletcher PW,Dias JA,Sanzo MA,Reichert LE Jr

    更新日期：1982-03-01 00:00:00

  • Cyclic AMP-dependent and independent stimulations of ovarian steroidogenesis by brain factors in the blowfly, Phormia regina.

    abstract：:The involvement of cyclic-AMP (cAMP) as a potential second messenger in the neurohormonal control of ovarian steroidogenesis was investigated in the adult female blowfly Phormia regina. Individual measurements of ovarian cAMP concentrations and of ovarian biosynthesis of ecdysteroids, stimulated after a protein meal, ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00312-9

    authors： Manière G,Vanhems E,Delbecque J

    更新日期：2000-10-25 00:00:00

  • Coming of age in the kisspeptin era: sex differences, development, and puberty.

    abstract：:The status of the neuroendocrine reproductive axis differs dramatically during various stages of development, and also differs in several critical ways between the sexes, including its earlier pubertal activation in females than males and the presence of neural circuitry that generates preovulatory hormone surges in f...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2010.01.017

    authors： Kauffman AS

    更新日期：2010-08-05 00:00:00

  • Tissue-specific corticosteroidogenesis in the rat.

    abstract：:The steroid aldosterone plays a major role in the maintenance of total body sodium homeostasis and also contributes to cardiovascular pathophysiology by mediating cardiac hypertrophy and fibrosis. In addition to classical adrenal production of aldosterone, endogenous tissue production of aldosterone has been observed ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(00)00258-6

    authors： Rudolph AE,Blasi ER,Delyani JA

    更新日期：2000-07-25 00:00:00

  • Calcium fluxes in rat thyroid FRTL-5 cells. Evidence for Ca2+ entry after stimulation with ATP.

    abstract：:The relationship between ATP-induced uptake of 45Ca2+ and the ATP-induced changes in [Ca2+]i was investigated in rat FRTL-5 thyroid cells. Addition of 1 microCi 45Ca2+/ml together with ATP induced a time- and dose-dependent increase in uptake of 45Ca2+, the uptake being still significantly above control after 30 min. ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(91)90105-2

    authors： Törnquist K

    更新日期：1991-08-01 00:00:00

  • Further characterization of the androgen receptor in rat testis.

    abstract：:Immature rat testes contain a specific binding protein for testosterone (T) and 5alpha-dihyrotestosterone (DHT) with physico-chemical properties similar to the cytoplasmic androgen receptors in the epididymis and ventral prostate but different from the testicular androgen-binding protein (ABP). Like the androgen recep...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(76)90058-7

    authors： McLean WS,Smith AA,Hansson V,Naess O,Nayfeh SN,French FS

    更新日期：1976-03-01 00:00:00

  • Cytoskeletal reorganisation, 1alpha,25-dihydroxy vitamin D3 and human MG63 osteoblast maturation.

    abstract：:Bone tissue is especially receptive to physical stimulation and agents with the capacity to mimic the signalling incurred via mechanical loading on osteoblasts may find an application in a bone regenerative setting. Recently this laboratory revealed that the major serum lipid, lysophosphatidic acid (LPA), co-operated ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2009.02.032

    authors： Mansell JP,Farrar D,Jones S,Nowghani M

    更新日期：2009-06-16 00:00:00

  • Yin Yang 1 is a multi-functional regulator of adipocyte differentiation in 3T3-L1 cells.

    abstract：:Yin Yang 1 (YY1) is an ubiquitously distributed transcription factor that belongs to the GLI-Kruppel class of zinc finger proteins. The mechanism by which YY1 regulates adipocyte differentiation remains unclear. In this study, we investigated the functional role of YY1 during adipocyte differentiation. During the earl...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.06.035

    authors： Han Y,Choi YH,Lee SH,Jin YH,Cheong H,Lee KY

    更新日期：2015-09-15 00:00:00

  • An in vitro bioassay to determine individual sensitivity to glucocorticoids: induction of FKBP51 mRNA in peripheral blood mononuclear cells.

    abstract：:Individual variation in sensitivity to glucocorticoids (GCs) poses a dilemma to the clinician. Currently available assays to determine individual sensitivity to GCs either seem imprecise, or they are based on mitogen-activated lymphocytes, although mitogens themselves may affect cellular GC sensitivity. To avoid these...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2003.12.011

    authors： Vermeer H,Hendriks-Stegeman BI,van Suylekom D,Rijkers GT,van Buul-Offers SC,Jansen M

    更新日期：2004-04-15 00:00:00

  • Effects of estrogens on striatal damage after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in male and female mice.

    abstract：:Emerging evidence shows a beneficial effect of estrogens for Parkinson's disease, yet the exact potency of these compounds implicated remain obscured. In this study, we investigated the neuroprotective effect of 17beta-estradiol and estrone against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal t...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2008.07.019

    authors： Ookubo M,Yokoyama H,Takagi S,Kato H,Araki T

    更新日期：2008-12-16 00:00:00

  • Spironolactone increases integrin beta3 gene expression in kidney and heart muscle cells.

    abstract：:In clinical trials of heart failure, spironolactone, an antagonist of the mineralocorticoid receptor (MR), reduced mortality rates by unknown mechanisms. We hypothesized that spironolactone functions by upregulating expression of certain cardiovascular genes. An RNA differential display technique was used to identify ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00112-0

    authors： Chun TY,Bloem L,Pratt JH

    更新日期：2002-08-30 00:00:00

  • Cyclic AMP and arachidonic acid: a tale of two pathways.

    abstract：:Increasing evidence in recent years has demonstrated the regulatory effects of arachidonic acid and its metabolites on steroid hormone production in various steroidogenic tissues. In trophic hormone-stimulated steroidogenesis, arachidonic acid is rapidly released from phospholipids. This release is dependent upon horm...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/s0303-7207(99)00130-6

    authors： Wang X,Stocco DM

    更新日期：1999-12-20 00:00:00

  • Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining.

    abstract：:Glucose-dependent insulinotropic polypeptide (GIP) plays an important role in stimulating insulin release in the pancreas as well as inhibiting gastric acid secretion in the stomach. GIP has been found in specific endocrine cells located in the mucosal layer of the small intestine and in the submandibular salivary gla...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(99)00106-9

    authors： Yeung CM,Wong CK,Chung SK,Chung SS,Chow BK

    更新日期：1999-08-20 00:00:00

  • Activin isoforms signal through type I receptor serine/threonine kinase ALK7.

    abstract：:Activins play a fundamental role in cell differentiation and development. Activin A signaling is mediated through a combination of activin type II receptors (ActRIIs) and the activin type IB receptor, ALK4. Signaling receptors of other activin isoforms remain to be elucidated. Here, we found that activin AB and activi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2004.03.009

    authors： Tsuchida K,Nakatani M,Yamakawa N,Hashimoto O,Hasegawa Y,Sugino H

    更新日期：2004-05-31 00:00:00

  • Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region.

    abstract：:17Beta hydroxysteroid dehydrogenase type 7 (HSD17B7) was described to possess dual functionality in steroidogenesis as well as in postsqualene cholesterol biosynthesis in vitro. In order to gain insight into the transcriptional regulation, and thereby into in vivo functionality of HSD17B7, we analyzed and compared the...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2005.10.016

    authors： Ohnesorg T,Adamski J

    更新日期：2006-03-27 00:00:00