Glucocorticoid receptor gene expression in rat pituitary gland intermediate lobe following ovariectomy.

abstract：:This study investigated the effects of SOD2 (MnSOD)-deficiency-induced excessive oxidative stress on ovarian steroidogenesis in vivo and isolated and cultured granulosa cells using WT and Sod2+/- mice. Basal and 48 h eCG-stimulated plasma progesterone levels were decreased ~50% in female Sod2+/- mice, whereas plasma p...

journal_title：Molecular and cellular endocrinology

authors： Zaidi SK,Shen WJ,Cortez Y,Bittner S,Bittner A,Arshad S,Huang TT,Kraemer FB,Azhar S

更新日期：2021-01-01 00:00:00

abstract：:Exendin-4 (Ex-4), a long-acting agonist of glucagon-like peptide-1 receptor, is a novel anti-diabetic drug that prevents β-cells against various toxicities. However, the mechanism and molecules mediating the protection procession of Ex-4 are not fully understood. We investigated the protective effect of Ex-4 against l...

journal_title：Molecular and cellular endocrinology

authors： Hong SW,Lee J,Park SE,Rhee EJ,Park CY,Oh KW,Park SW,Lee WY

更新日期：2012-10-15 00:00:00

abstract：:All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply of substrates to matc...

journal_title：Molecular and cellular endocrinology

authors： Nagendran J,Waller TJ,Dyck JR

更新日期：2013-02-25 00:00:00

abstract：:Set/template-activating factor (TAF)-Ibeta, part of the Set-Can oncogene product found in acute undifferentiated leukemia, is a component of the inhibitor of acetyltransferases (INHAT) complex. Set/TAF-Ibeta interacted with the DNA-binding domain of the glucocorticoid receptor (GR) in yeast two-hybrid screening, and r...

journal_title：Molecular and cellular endocrinology

authors： Ichijo T,Chrousos GP,Kino T

更新日期：2008-02-13 00:00:00

abstract：:The modulation of cardiac growth by estrogen in healthy mice is not completely understood. The aim was to investigate the effects of estrogen on cardiac growth in healthy mice lacking either estrogen receptor (ER) α or β. Wild-type (WT), ERα knockout (ERKO) and ERβ knockout (BERKO) 2-month-old mice were ovariectomized...

journal_title：Molecular and cellular endocrinology

authors： Kararigas G,Nguyen BT,Jarry H

更新日期：2014-02-15 00:00:00

abstract：:Bone tissue is especially receptive to physical stimulation and agents with the capacity to mimic the signalling incurred via mechanical loading on osteoblasts may find an application in a bone regenerative setting. Recently this laboratory revealed that the major serum lipid, lysophosphatidic acid (LPA), co-operated ...

journal_title：Molecular and cellular endocrinology

authors： Mansell JP,Farrar D,Jones S,Nowghani M

更新日期：2009-06-16 00:00:00

abstract：:The luteinizing hormone receptor (LHR), one of the three glycoprotein hormone receptors, is necessary for critical reproductive processes, including gonadal steroidogenesis, oocyte maturation and ovulation, and male sex differentiation. Moreover, it has been postulated to contribute to certain neoplasms, particularly ...

journal_title：Molecular and cellular endocrinology

authors： Puett D,Angelova K,da Costa MR,Warrenfeltz SW,Fanelli F

更新日期：2010-11-25 00:00:00

abstract：:Accumulating evidence suggests that the human follitropin receptor is unusually sensitive to mutation. Previous results (Mol. Cell. Endo. 166 (2000) 101) determined that scanning mutations in a.a. 12-14 and 22-30 neither bound follitropin nor were present on the cell surface, suggesting that these regions are involved...

journal_title：Molecular and cellular endocrinology

authors： Nechamen CA,Dias JA

更新日期：2003-03-28 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) superfamily comprises more than 40 members, classified on the basis of structural similarity. These factors elicit a diverse range of cellular responses in insects, nematodes and vertebrates, via serine/threonine kinase receptors and intracellular Smad proteins, which whe...

journal_title：Molecular and cellular endocrinology

authors： Drummond AE,Dyson M,Le MT,Ethier JF,Findlay JK

更新日期：2003-04-28 00:00:00

abstract：:Type I pseudohypoaldosteronism (PHA1) is a rare form of mineralocorticoid resistance characterized by neonatal renal salt wasting and failure to thrive. Typical biochemical features include high levels of plasma aldosterone and renin, hyponatremia and hyperkalemia. Different mutations of the human mineralocorticoid re...

journal_title：Molecular and cellular endocrinology

authors： Sartorato P,Khaldi Y,Lapeyraque AL,Armanini D,Kuhnle U,Salomon R,Caprio M,Viengchareun S,Lombès M,Zennaro MC

更新日期：2004-03-31 00:00:00

abstract：:Thyroid hormone receptor alpha (TRalpha) and the oncoprotein v-erbA (a mutated form of TRalpha incapable of binding T3) bind as heterodimers with retinoid X receptor (RXR) to DNA sequences with different orientations of AGGTCA half sites. v-erbA can also form homodimers, whereas, TRalpha1 homodimerizes poorly. Therefo...

journal_title：Molecular and cellular endocrinology

authors： Zubkova I,Subauste JS

更新日期：2003-01-31 00:00:00

abstract：:The present study investigated the pattern and site of expression of the prolactin receptor gene in the testis of the seasonally breeding Soay sheep. In experiment 1, Northern blot analysis confirmed expression of the prolactin receptor gene in the testis which was encoded by RNA transcripts of approximately 3.6, 11.2...

journal_title：Molecular and cellular endocrinology

authors： Jabbour HN,Lincoln GA

更新日期：1999-02-25 00:00:00

abstract：:While the role of dietary fats in breast cancer remains controversial, the recent cloning of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, from human breast cancer cells lines provides a potential molecular link. Several fatty acids from four classes of dietary fats were tes...

journal_title：Molecular and cellular endocrinology

authors： Thoennes SR,Tate PL,Price TM,Kilgore MW

更新日期：2000-02-25 00:00:00

abstract：:Endometriosis, one of the most common benign gynecological diseases, affects millions of women of childbearing age. Endometriosis-associated pain is a major cause of disability and compromised quality of life in women. Neuropathic mechanisms are believed to play an important role. An imbalanced sympathetic and sensory...

journal_title：Molecular and cellular endocrinology

authors： Liang Y,Yao S

更新日期：2016-03-15 00:00:00

abstract：:Insulin receptor substrate-1 (IRS-1) is a protein expressed in 3T3-L1 adipocytes that is involved in most, if not all of the biological responses to insulin. Chronic exposure of these cells to insulin down-regulates IRS-1 by stimulating its degradation (Rice, K.M., Turnbow, M.A. and Garner, C.W. (1993) Biochem. Biophy...

journal_title：Molecular and cellular endocrinology

authors： Smith LK,Rice KM,Garner CW

更新日期：1996-08-30 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is reportedly produced in normal islets and insulinomas. PTHrP induces differentiation in some cell-types and growth in others. We examined whether PTHrP production is greater in well-differentiated or growing beta cells and whether PTHrP induces differentiation or growth in...

journal_title：Molecular and cellular endocrinology

authors： Sawada Y,Zhang B,Okajima F,Izumi T,Takeuchi T

更新日期：2001-09-01 00:00:00

abstract：:Autodigestion of nuclei isolated from the androgen-dependent Shionogi mouse mammary carcinoma revealed the presence of endogenous endonuclease activity which was stimulated by Ca2+ and Mg2+ and generated a repeating pattern of DNA fragments with an average monomeric size of 179 base pairs. The nuclear concentration of...

journal_title：Molecular and cellular endocrinology

authors： Giles MG,Rennie PS,Bruchovsky N

更新日期：1986-05-01 00:00:00

abstract：:The outcome and reproductive function were examined among patients with malignant ovarian germ cell tumors treated since 1980. Between 1980 and 2001, fertility-sparing surgery was performed in 26 women, 23 of whom received adjuvant chemotherapy. With a median follow-up of 66.6 months, all patients have been alive, wit...

journal_title：Molecular and cellular endocrinology

authors： Sagae S,Sasaki H,Nishioka Y,Terasawa K,Kudo R

更新日期：2003-04-28 00:00:00

abstract：:The direct inhibitory of gonadotropin-releasing hormone (GnRH) upon testicular androgen production was studied in cultured testicular cells. Enzyme-dispersed testicular cells from immature hypophysectomized rats were cultured for 6 days in a serum-free medium with or without various hormones. Culture media were change...

journal_title：Molecular and cellular endocrinology

authors： Hsueh AJ,Schreiber JR,Erickson GF

更新日期：1981-01-01 00:00:00

abstract：:Fibroblasts from three patients with vitamin D-dependency rickets type II were used to study mutations in the 1,25-dihydroxyvitamin D3 receptor responsible for this hereditary disease. Normal human fibroblasts contain 43 +/- 13 fmol receptor/mg protein as determined by immunoradiometric assay and 22 +/- 3 fmol/mg by l...

journal_title：Molecular and cellular endocrinology

authors： Wiese RJ,Goto H,Prahl JM,Marx SJ,Thomas M,al-Aqeel A,DeLuca HF

更新日期：1993-01-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) is a stroma-derived mitogen mediating epithelial-stromal interactions. We investigated the role of KGF during epithelial-stromal interactions accompanying ruminant mammogenesis. Target-specificity of KGF was demonstrated in that KGF-stimulated proliferation of bovine mammary epithelial...

journal_title：Molecular and cellular endocrinology

authors： Hovey RC,Davey HW,Vonderhaar BK,Mackenzie DD,McFadden TB

更新日期：2001-07-05 00:00:00

abstract：:Studies on the age-related decline of growth hormone (GH) release have ignored that the population of GH-producing cells (somatotropes) is heterogeneous. In aging male rats, centrifugation of dispersed pituitary cells in a density gradient yields two somatotrope subpopulations, i.e. low- (LD) and high-density (HD) cel...

journal_title：Molecular and cellular endocrinology

authors： Dobado-Berrios PM,Ruiz-Navarro A,Lopez-Pedrera R,Gonzalez de Aguilar JL,Torronteras R,Hidalgo-Diaz C,Gracia-Navarro F

更新日期：1996-10-30 00:00:00

abstract：:Ghrelin is the only known circulating hormone that acts on peripheral and central targets to increase food intake and promote adiposity. The present review focuses on the possible clinical relevance of ghrelin in the regulation of human feeding behavior in individuals with obesity and other eating disorders such as Pr...

journal_title：Molecular and cellular endocrinology

authors： Yi CX,Heppner K,Tschöp MH

更新日期：2011-06-20 00:00:00

abstract：:The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells. In the present study we have employed MCF-7 cells to investigate the effects of TPA on inositol lipid signalling, the puta...

journal_title：Molecular and cellular endocrinology

authors： Patel KV,Schrey MP

更新日期：1992-06-01 00:00:00

abstract：:Progesterone elicits a rapid, transient calcium influx in sperm that is a prerequisite for the progesterone-induced acrosome reaction. The possibility that the GABAA receptor/chloride channel was the receptor that mediated the progesterone-induced calcium influx in human sperm was examined. A-ring reduced 3 alpha-hydr...

journal_title：Molecular and cellular endocrinology

authors： Blackmore PF,Im WB,Bleasdale JE

更新日期：1994-09-01 00:00:00

abstract：:In this study we have investigated the protein phosphorylation pattern in the membrane fraction prepared from bovine luteal cells. The phosphorylation reaction was carried out in vitro, under defined conditions, using either [gamma-32P]ATP or [gamma-35S]ATP as the phosphate donor. The results obtained show that [gamma...

journal_title：Molecular and cellular endocrinology

authors： Budnik LT,Mukhopadhyay AK

更新日期：1990-03-05 00:00:00

abstract：:The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is essential for the biosynthesis of all active steroid hormones. The 3beta-HSD enzyme consists in multiple isoforms, each the product of a distinct gene. In the mouse, six tissue-specific isoforms have been identified. These isoforms are expressed in...

journal_title：Molecular and cellular endocrinology

authors： Peng L,Arensburg J,Orly J,Payne AH

更新日期：2002-02-22 00:00:00

abstract：:The ovarian granulosa cell has previously been shown to be a site of insulin-like growth factor (IGF) I production, reception, and action. It is the objective of this study to characterize in greater detail the soluble IGF binding activity released by this cell type. To this end, use was made of granulosa cells from i...

journal_title：Molecular and cellular endocrinology

authors： Adashi EY,Resnick CE,Hernandez ER,Hurwitz A,Rosenfeld RG

更新日期：1990-12-21 00:00:00

abstract：:Prostate cancer (PCa) is a major health issue in the Western world. Current clinical imperatives for this disease include better stratification of indolent versus aggressive disease to enable improved patient management, as well as the identification of more effective therapies for the prevention and treatment of meta...

journal_title：Molecular and cellular endocrinology

authors： Das R,Feng FY,Selth LA

更新日期：2019-01-15 00:00:00

abstract：:The glycoprotein hormones luteinizing hormone (LH) and human chorionic gonadotropin (hCG), both of which act through the LH receptor, play an important role in the regulation of both male and female gonadal function. Testicular androgen production by the Leydig cells is almost entirely dependent on LH/hCG action, whil...

journal_title：Molecular and cellular endocrinology

authors： Themmen AP,Martens JW,Brunner HG

更新日期：1998-10-25 00:00:00