当前位置： SCI文献检索 > MOLECULAR AND CELLULAR ENDOCRINOLOGY期刊下所有文献 > Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis.

Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis.

Abstract：

:The enzyme aromatase converts androgens to estrogens, which have recently been postulated to be essential for testicular development and fertility. Understanding the mechanisms that regulate aromatase activity in the testis may therefore have implications for treatment of male infertility. Aromatase is encoded by the CYP19 gene, which uses multiple tissue-specific alternative promoters. In the testis, the proximal promoter PII drives aromatase expression. PII activity requires a nuclear receptor half-site, CAAGGTCA, to which two orphan receptors; SF-1 and LRH-1, have been shown to bind in vitro. The aim of this study was to investigate expression of aromatase and LRH-1 in the developing rat testis and define the ability of LRH-1 to induce aromatase expression in the testicular cells where both are expressed. We show that aromatase and LRH-1 are present throughout all stages of development of the rat testis, although the sites and levels of expression vary. The pattern of LRH-1 expression was broadly similar to that of aromatase. In adult animals higher levels of expression were observed in Leydig and germ cells. Over-expression of LRH-1 in primary rat Leydig and germ cells by adenoviral infection strongly increased endogenous aromatase mRNA levels, demonstrating the ability of LRH-1 to stimulate aromatase expression in vivo. We also observed binding of endogenous LRH-1 to the aromatase promoter II by chromatin immunoprecipitation. These data provide evidence that LRH-1 plays an important role in the regulation of testicular aromatase expression, and implicate LRH-1 as a regulator of rat spermatogenesis, in which estrogens are emerging as important mediators.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Sierens J,Jakody I,Poobalan Y,Meachem SJ,Knower K,Young MJ,Sirianni R,Pezzi V,Clyne CD

doi

10.1016/j.mce.2010.03.001

subject

Has Abstract

pub_date

2010-07-29 00:00:00

pages

307-13

issue

2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(10)00134-6

journal_volume

323

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR ENDOCRINOLOGY文献大全
  • A periodicity in the response of SJL/J thymocytes to isoproterenol. Simulation by cell lines.

    abstract：:Thymocytes from SJL/J mice exhibit a periodicity in their response to hormonal stimulation with isoproterenol. This periodicity (5-9 days) is expressed in large changes in the intensity of the response (peak levels of intracellular cAMP which vary approximately 6-fold), and in the response pattern, i.e., in the occurr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(90)90134-t

    authors： Riven-Kreitman R,Tauber-Finkelstein M,Zipori D,Shaltiel S

    更新日期：1990-10-22 00:00:00

  • A review on the mechanism of iodide metabolic dysfunction in differentiated thyroid cancer.

    abstract：:The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly worldwide, and the risk factors remain unclear. With the growing number of patients with DTC, the related issues have been gradually highlighted. 131Iodide (131I) is an important treatment for DTC and has the potential to reduce the risk ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2018.09.002

    authors： Zhao Y,Zhong L,Yi H

    更新日期：2019-01-05 00:00:00

  • The role of FSCN1 in migration and invasion of pituitary adenomas.

    abstract：:The prediction of invasion or malignant behavior in PAs remains challenging. FSCN1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types. The objective of the study was to evaluate the expression of FSCN1 in 312 PAs cases, and to analyze its association with ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.10.021

    authors： Liu C,Gao H,Cao L,Gui S,Liu Q,Li C,Li D,Gong L,Zhang Y

    更新日期：2016-01-05 00:00:00

  • Fatty acid flux in adipocytes: the in's and out's of fat cell lipid trafficking.

    abstract：:The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and b...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2009.08.015

    authors： Thompson BR,Lobo S,Bernlohr DA

    更新日期：2010-04-29 00:00:00

  • Desensitization of cultured rat Sertoli cells by follicle-stimulating hormone and by L-isoproterenol.

    abstract：:When Sertoli cell-enriched cultures derived from 19-day-old Wistar rats are exposed to FSH or L-isoproterenol, cAMP accumulates in the medium. Previous contact of cultured cells with either one of these agents results in a reversible state of desensitization. During secondary stimulation up to 20 times less cAMP accum...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(80)90075-1

    authors： Verhoeven G,Cailleau J,de Moor P

    更新日期：1980-11-01 00:00:00

  • Interaction of indomethacin with the antilipolytic effect of prostaglandin E2 in rat adipocytes.

    abstract：:The interaction of indomethacin with the antilipolytic effect of prostaglandin E2 (PGE2) was investigated in rat adipocytes in order to reveal a possible role of endogenous PGs in adipose tissue. Adipocytes isolated from rats treated in vivo for 5 days with indomethacin were compared with non-treated control rats. The...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(88)90056-1

    authors： Richelsen B

    更新日期：1988-07-01 00:00:00

  • Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro.

    abstract：:A recent hypothesis suggests that a high glycaemic load diet-associated increase of insulin-like growth factor-1 (IGF-1) and insulin may promote acne by reducing nuclear localization of the forkhead box-O1 (FoxO1) transcription factor via activation of the phosphoinositide-3-kinase (PI3K)/Akt pathway. Using SZ95 seboc...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2015.08.001

    authors： Mirdamadi Y,Thielitz A,Wiede A,Goihl A,Papakonstantinou E,Hartig R,Zouboulis CC,Reinhold D,Simeoni L,Bommhardt U,Quist S,Gollnick H

    更新日期：2015-11-05 00:00:00

  • Insulin effects on human red blood cells.

    abstract：:The effect of insulin on human red blood cells was investigated, both on intact cells and on isolated plasma membranes, testing the responsiveness of membrane-bound enzymes--such as (Na+-K+)-ATPase and 5'-nucleotidase--as well as the ouabain binding and ionic fluxes. It appears that insulin stimulates Na-pumping mecha...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(86)90087-0

    authors： Baldini P,Incerpi S,Pascale E,Rinaldi C,Verna R,Luly P

    更新日期：1986-07-01 00:00:00

  • Somatostatin analogs regulate tumor corticotrophs growth by reducing ERK1/2 activity.

    abstract：:Pasireotide has been associated with tumor shrinkage in patients with Cushing's disease subjected to long term treatment. However, to date the implicated molecular mechanisms are poorly elucidated. Here, we tested pasireotide-mediated cytostatic and cytotoxic effects in ACTH-secreting primary tumor cultures and murine...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2018.12.022

    authors： Treppiedi D,Giardino E,Catalano R,Mangili F,Vercesi P,Sala E,Locatelli M,Arosio M,Spada A,Mantovani G,Peverelli E

    更新日期：2019-03-01 00:00:00

  • Characterization of complementary deoxyribonucleic acids encoding preprogalanin and its alternative splice variants in the goldfish.

    abstract：:This paper reports the identification of five preprogalanin complementary deoxyribonucleic acids encoding preprogalanin peptides in the goldfish. Preprogalanin 1A, 1B and 1C are encoded in galanin gene 1 and 2A and 2B are encoded in gene 2. Preprogalanin 1B and 2B have a 24 amino acids insert in the mature peptide reg...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00301-5

    authors： Unniappan S,Lin X,Peter RE

    更新日期：2003-02-28 00:00:00

  • Cytochrome P-450 and the aromatization of 16alpha-hydroxytestosterone and androstenedione by human placental microsomes.

    abstract：:When measured in vitro using human placental microsomal preparations, the aromatization of 16alpha-hydroxytestosterone to estriol and androstenedione to estrone and estradiol proceeds at almost identical initial rates. Important differences between 16alpha-hydroxytestosterone and adrostenedione aromatization are evide...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(76)90010-1

    authors： Canick JA,Ryan KJ

    更新日期：1976-12-01 00:00:00

  • The biology of progesterone receptor in the normal mammary gland and in breast cancer.

    abstract：:This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse mammary gland that has been used extensively as an experimental model. Studies have led to the concept that progesterone controls proliferation and morphogenesis of the luminal epithelium in a tightly orchestrated manner at distinc...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2011.10.030

    authors： Obr AE,Edwards DP

    更新日期：2012-06-24 00:00:00

  • Regulation of steroid production in cultured porcine thecal cells by transforming growth factor-beta.

    abstract：:Evidence that transforming growth factor-beta (TGF beta) is produced by porcine thecal cells and acts upon porcine granulosa cells suggests that this peptide may be a local regulator of follicular function in this species. The objective of the present study was to investigate the effects of TGF beta on steroidogenesis...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90131-o

    authors： Engelhardt H,Tekpetey FR,Gore-Langton RE,Armstrong DT

    更新日期：1992-05-01 00:00:00

  • Relationship between renin mRNA and renin secretion in adrenalectomized, salt-depleted, or converting enzyme inhibitor-treated rats.

    abstract：:Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Relative amounts of renin mRNA were measured by densitometric Northern blot analysis using a 32P-labeled 700 bp mouse subma...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(87)90020-7

    authors： Ludwig G,Ganten D,Murakami K,Fasching U,Hackenthal E

    更新日期：1987-04-01 00:00:00

  • The steroidogenic effect of single-chain bovine LH analogs in cultured bovine follicular cells.

    abstract：:Single-chain gonadotropin analogs had been constructed for the purpose of structure-function studies and analog design. Incorporation of a spacer derived from the carboxyl terminal peptide (CTP) of the choriogonadotropin (CG) beta subunit between the tethered subunit domains of the human gonadotropins is beneficial fo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2006.03.011

    authors： Braw-Tal R,Pen S,Grinberg M,Nakav S,Ben-Menahem D

    更新日期：2006-06-27 00:00:00

  • Role of epididymal receptor HE6 in the regulation of sperm microenvironment.

    abstract：:HE6 (GPR64) is a highly conserved, tissue-specific heptahelical receptor of the human epididymis. The seven transmembrane (TM7) domains are a hallmark of G-protein-coupled receptors (GPCRs) which have a proven history of being excellent therapeutic targets. Of all currently marketed drugs, >30% are modulators of speci...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2005.12.023

    authors： Kirchhoff C,Obermann H,Behnen M,Davies B

    更新日期：2006-05-16 00:00:00

  • Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells.

    abstract：:Skeletal muscle is the major site of postprandial glucose disposal and augmenting glucose uptake into this tissue may attenuate insulin resistance that precedes type 2 diabetes mellitus. Here, we investigated the effect of pongamol, an identified lead molecule from the fruits of Pongamia pinnata, on glucose uptake and...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2011.03.023

    authors： Tamrakar AK,Jaiswal N,Yadav PP,Maurya R,Srivastava AK

    更新日期：2011-06-06 00:00:00

  • Isolation of cells from rat seminal vesicles and epididymis and their use in studying androgen action.

    abstract：:Cells isolated enzymically from seminal vesicles and epididymides of normal and castrated rats were shown by electron microscopy to be intact and representative of the tissue. The cells synthesize and secrete tissue-specific proteins. Short-term incorporation of [3H]uridine and [35S]methionine was measured to determin...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(81)90071-x

    authors： Higgins SJ,Brooks DE,Fuller FM

    更新日期：1981-08-01 00:00:00

  • Elimination of adrenocortical apolipoprotein E production does not impact glucocorticoid output in wild-type mice.

    abstract：:Apolipoprotein E (APOE) deficient mice exhibit unexplained hypercorticosteronemia. Given that APOE is also produced locally within the adrenals, we evaluated the effect of adrenal-specific APOE deficiency on the glucocorticoid function. Hereto, one adrenal containing or lacking APOE was transplanted into adrenalectomi...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2019.04.001

    authors： van der Sluis RJ,Depuydt MAC,Verwilligen RAF,Hoekstra M,Van Eck M

    更新日期：2019-06-15 00:00:00

  • Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells.

    abstract：:Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Fo...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2014.10.006

    authors： Chu R,Liu SY,Vlantis AC,van Hasselt CA,Ng EK,Fan MD,Ng SK,Chan AB,Du J,Wei W,Liu X,Liu Z,Chen GG

    更新日期：2015-01-05 00:00:00

  • The natural compounds atraric acid and N-butylbenzene-sulfonamide as antagonists of the human androgen receptor and inhibitors of prostate cancer cell growth.

    abstract：:Extracts from the plant Pygeum africanum are widely used in the therapy of benign prostate hyperplasia (BPH) and in combinational therapy for prostate cancer, the second leading cause of cancer death and the mostly diagnosed form of cancer in men. The androgen receptor (AR) plays a crucial role in the development of t...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2010.09.013

    authors： Roell D,Baniahmad A

    更新日期：2011-01-30 00:00:00

  • Luteinizing hormone and human chorionic gonadotropin: origins of difference.

    abstract：:Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are widely recognized for their roles in ovulation and the support of early pregnancy. Aside from the timing of expression, however, the differences between LH and hCG have largely been overlooked in the clinical realm because of their similar molecular s...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2013.12.009

    authors： Choi J,Smitz J

    更新日期：2014-03-05 00:00:00

  • Biphasic effects of exogenous ganglioside GM3 on follicle-stimulating hormone-dependent expression of luteinizing hormone receptor in cultured granulosa cells.

    abstract：:The major ganglioside NeuAc alpha 2-->3Gal beta 1-->4Glc beta 1-->1Cer (GM3) present in cultured rat granulosa cells was examined for potential function in the expression of luteinizing hormone (LH) receptor on the cell surface in response to follicle-stimulating hormone (FSH). Synthesis of GM3 was stimulated concentr...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90008-t

    authors： Hattori M,Horiuchi R

    更新日期：1992-10-01 00:00:00

  • Na+/H+ exchange is responsible for intracellular pH regulation in insulin-secreting HIT-T15 cells.

    abstract：:The addition of glucose to suspensions of HIT-T15 insulinoma cells caused a small, transient acidification followed by a gradual, progressive alkalinisation, as assessed by the fluorescent pH-sensitive dye 2',7'-biscarboxyethyl-5'-(6')-carboxyfluorescein (BCECF). Treatment of cells with acetate or lactate produced an ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(90)90070-o

    authors： Trebilcock R,Lynch A,Tomlinson S,Best L

    更新日期：1990-05-28 00:00:00

  • The role of acid-labile subunit (ALS) in the modulation of GH-IGF-I action.

    abstract：:Acid-labile subunit (ALS) deficiency (ACLSD) constitutes the first monogenic defect involving a member of the Insulin-like Growth Factor (IGF) binding protein system. The lack of ALS completely disrupts the circulating IGF system. Autocrine/paracrine action of local produced IGF-I could explain the mild effect on grow...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mce.2020.111006

    authors： Domené S,Domené HM

    更新日期：2020-12-01 00:00:00

  • Enhanced activity of the cardiac endocrine system during right ventricular hypertrophy.

    abstract：:In a model of pulmonary hypertension induced by a single injection of monocrotaline (MCT), we observed a time-dependent right ventricular hypertrophy, which became apparent in treated rats 21 days after administration of MCT and progressed through day 45. Associated with this right ventricular hypertrophy were time-de...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(89)90011-7

    authors： Oehlenschlager WF,Kurtz DT,Baron DA,Currie MG

    更新日期：1989-04-01 00:00:00

  • Ets-1 activates parathyroid hormone-related protein gene expression in tumorigenic breast epithelial cells.

    abstract：:Parathyroid hormone-related protein (PTHrP) is produced by many tumors not associated with humoral hypercalcemia, including breast cancers. In this study, we used three human immortalized mammary epithelial cell lines that differ in tumorigenicity and PTHrP expression. Using RT-PCR we investigated 5' and 3' alternativ...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0303-7207(02)00298-8

    authors： Cataisson C,Gordon J,Roussière M,Abdalkhani A,Lindemann R,Dittmer J,Foley J,Bouizar Z

    更新日期：2003-06-30 00:00:00

  • Evidence for a role for protein kinase C in the modulation of bombesin-activated cellular signalling in human breast cancer cells.

    abstract：:The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells. In the present study we have employed MCF-7 cells to investigate the effects of TPA on inositol lipid signalling, the puta...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/0303-7207(92)90260-d

    authors： Patel KV,Schrey MP

    更新日期：1992-06-01 00:00:00

  • Role of melanocortin receptor accessory proteins in the function of zebrafish melanocortin receptor type 2.

    abstract：:In this paper, we identify three different MRAPs in zebrafish, zfMRAP1, zfMRAP2a and zfMRAP2b, and demonstrate that zfMC2R is not functional in the absence of MRAP expression. ZfMRAP1 expression was restricted to adipose tissue and the anterior kidney whereas MRAP2a and MRAP2b were expressed in all the tissues tested....

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2010.01.032

    authors： Agulleiro MJ,Roy S,Sánchez E,Puchol S,Gallo-Payet N,Cerdá-Reverter JM

    更新日期：2010-05-14 00:00:00

  • Differentiation of Seminiferous Tubule-Associated Stem Cells into Leydig Cell and Myoid Cell Lineages.

    abstract：:Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig o...

    journal_title：Molecular and cellular endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.mce.2021.111179

    authors： Zhao X,Wen X,Ji M,Guan X,Chen P,Hao X,Chen F,Hu Y,Duan P,Ge RS,Chen H

    更新日期：2021-01-27 00:00:00