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Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development.

Abstract：

:Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase type 1 are involved in the key steps of 17β-estradiol biosynthesis. Structure-function studies of aromatase, estrone sulfatase and 17β-hydroxysteroid dehydrogenase type 1 are important to evaluate the molecular basis of the interaction between these enzymes and their inhibitors. Selective and potent inhibitors of the three enzymes have been developed as antiproliferative agents in hormone-dependent breast carcinoma. New treatment strategies for hormone-dependent breast cancer are discussed.

journal_name

Mol Cell Endocrinol

journal_title

Molecular and cellular endocrinology

authors

Hong Y,Chen S

doi

10.1016/j.mce.2010.09.012

subject

Has Abstract

pub_date

2011-07-04 00:00:00

pages

120-6

issue

2

eissn

0303-7207

issn

1872-8057

pii

S0303-7207(10)00473-9

journal_volume

340

pub_type

杂志文章,评审

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