Laparoscopic sleeve gastrectomy ameliorates mRNA expression of inflammation-related genes in subcutaneous adipose tissue but not in peripheral monocytes of obese patients.

abstract：:At 14 days of age, hypothyroid and normal rats are rendered hypoglycaemic by insulin injection and the subsequent induction in adrenal tyrosine hydroxylase (TH) is studied. Hypothyroidism impairs both the intensity and the time-course of adrenal TH induction. ...

journal_title：Molecular and cellular endocrinology

authors： Gripois D,Valens M

更新日期：1984-11-01 00:00:00

abstract：:The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the o...

journal_title：Molecular and cellular endocrinology

authors： Spiga F,Lightman SL

更新日期：2015-06-15 00:00:00

abstract：OBJECTIVES:The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos. METHODS:The temporal expression of low-density lipoprotein receptor (LDLR) and side-chain cleavage cytochrome P450 (P450scc) mRNAs in mouse oocytes and preimplantation embryos up to the hatched bl...

journal_title：Molecular and cellular endocrinology

authors： Sato N,Kawamura K,Fukuda J,Honda Y,Sato T,Tanikawa H,Kodama H,Tanaka T

更新日期：2003-04-28 00:00:00

abstract：CONTEXT:Hyperandrogenic states and obesity in women are associated with insulin-resistance. Androgens reduce glucose uptake in adipose cells and increase TNFα production in peripheral monocytes. Inflammatory cytokines have a known detrimental effect on insulin resistance. The aim of the present study was to explore the...

journal_title：Molecular and cellular endocrinology

authors： Crisosto N,Flores C,Maliqueo M,Echiburú B,Vásquez J,Maluenda F,Sir-Petermann T

更新日期：2017-03-15 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR)α have been shown to exert immunomodulatory effects in autoimmune disorders; no study evaluated the effect of PPARα activation in Graves' ophthalmopathy (GO). We show the presence of PPARα, δ and γ in GO fibroblasts and preadipocytes. PPARα activators have a potent inh...

journal_title：Molecular and cellular endocrinology

authors： Antonelli A,Ferrari SM,Frascerra S,Ruffilli I,Gelmini S,Minuto M,Pupilli C,Miccoli P,Sellari-Franceschini S,Ferrannini E,Fallahi P

更新日期：2012-02-26 00:00:00

abstract：:Our previous study revealed the particular expression patterns of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 1 (IGFBP1) in the Qinghai-Tibet plateau root vole (Microtus oeconomus) under hypoxic challenge. Here we report the molecular mechanisms of Igf gene regulation associated ...

journal_title：Molecular and cellular endocrinology

authors： Zhang S,Zhao Y,Hu X,Liu Z,Chen X,Chen X,Du J

更新日期：2013-08-25 00:00:00

abstract：:The interaction of tamoxifen (ICI 46,474), a synthetic antiestrogen, with uterine cytosol proteins of immature calf and rat has been studied directly using the tritiated compound labeled with a high specific activity. The binding complexes were measured by the dextrancoated charcoal, protamine sulfate and hydroxyapati...

journal_title：Molecular and cellular endocrinology

authors： Capony F,Rochefort H

更新日期：1978-07-01 00:00:00

abstract：:The endocrine function of the ovary is dependent upon the ovarian follicle, which on a cellular basis consists of an oocyte surrounded by adjacent somatic cells responsible for generating sex steroid hormones and maintenance of hormonal stasis with the hypothalamic-pituitary axis. As females age, both fertility and th...

journal_title：Molecular and cellular endocrinology

authors： Truman AM,Tilly JL,Woods DC

更新日期：2017-04-15 00:00:00

abstract：:Experimental data indicate that metal ions such as Na(+), Ca(2+) and Mg(2+), which are present in millimolar concentrations in the extracellular environment, modulate binding of ligands to plasma membrane receptors. Here, we briefly review structural studies that demonstrate that various types of ligands, including pe...

journal_title：Molecular and cellular endocrinology

authors： Ananthanarayanan VS,Kerman A

更新日期：2006-02-26 00:00:00

abstract：:The steroid aldosterone plays a major role in the maintenance of total body sodium homeostasis and also contributes to cardiovascular pathophysiology by mediating cardiac hypertrophy and fibrosis. In addition to classical adrenal production of aldosterone, endogenous tissue production of aldosterone has been observed ...

journal_title：Molecular and cellular endocrinology

authors： Rudolph AE,Blasi ER,Delyani JA

更新日期：2000-07-25 00:00:00

abstract：:The chum salmon insulin-like growth factor II (IGF-II) gene is highly expressed in liver tissue. In this study we demonstrate that two transcription factors, Sp1 and C/EBPbeta, are involved in the enhanced expression of the salmon IGF-II gene. The presence of the fish homolog for C/EBPbeta in salmon liver RNA was conf...

journal_title：Molecular and cellular endocrinology

authors： Palamarchuk AY,Kavsan VM,Sussenbach JS,Holthuizen PE

更新日期：2001-02-14 00:00:00

abstract：:With close genomic and phenotypic similarity to humans, nonhuman primate models provide comprehensive epigenetic mimics of polycystic ovary syndrome (PCOS), suggesting early life targeting for prevention. Fetal exposure to testosterone (T), of all nonhuman primate emulations, provides the closest PCOS-like phenotypes,...

journal_title：Molecular and cellular endocrinology

authors： Abbott DH,Nicol LE,Levine JE,Xu N,Goodarzi MO,Dumesic DA

更新日期：2013-07-05 00:00:00

abstract：:The androgen receptor (AR) is a ligand-dependent transcription activator responsible for male sexual development. In order to specifically inhibit the AR pathway, dominant negative ARs were constructed by inactivation of the major transactivation domains of the wild type AR and fusing this mutant (AR122) to the Krüppe...

journal_title：Molecular and cellular endocrinology

authors： Bramlett KS,Dits NF,Sui X,Jorge MC,Zhu X,Jenster G

更新日期：2001-10-25 00:00:00

abstract：:In recent years it has become evident that glucocorticoid receptor (GR) action in the nucleus is highly dynamic, characterized by a rapid exchange at the chromatin template. This stochastic mode of GR action couples perfectly with a deterministic pulsatile availability of endogenous ligand in vivo. The endogenous gluc...

journal_title：Molecular and cellular endocrinology

authors： Conway-Campbell BL,Pooley JR,Hager GL,Lightman SL

更新日期：2012-01-30 00:00:00

abstract：:We review in this article recent findings on the effects of cell proximity (nearness to each other) on anterior pituitary cell function in vitro. Important cellular processes, including protein synthesis, basal hormone release, response to hypothalamic regulatory factors and signal transduction can change as a functio...

journal_title：Molecular and cellular endocrinology

authors： Perez FM,Rose JC,Schwartz J

更新日期：1995-06-01 00:00:00

abstract：:The binding of thyrotropin (TSH) to the TSH receptor (TSHR) activates two signaling pathways: the cAMP-protein kinase A (PKA) and the protein kinase C (PKC) systems. We have recently demonstrated that TSH activates the Janus kinases (JAK)/signal transducer and activator of transcription (STAT) pathway via TSHR. This s...

journal_title：Molecular and cellular endocrinology

authors： Park YJ,Park ES,Kim MS,Kim TY,Lee HS,Lee S,Jang IS,Shong M,Park DJ,Cho BY

更新日期：2002-08-30 00:00:00

abstract：:The human growth hormone/human chorionic somatomammotropin (hGH/hCS) gene cluster contains five genes: hGH-N, hGH-V, hCS-B, and hCS-L. In this study, the nature of splicing products of their primary transcripts (except hCH-L) was analyzed by nuclease mapping as well as by reverse transcription-polymerase chain reactio...

journal_title：Molecular and cellular endocrinology

authors： Palmetshofer A,Zechner D,Luger TA,Barta A

更新日期：1995-09-22 00:00:00

abstract：:Estrogen plays a major role in bone mineral homeostasis, maintaining a balance between bone formation and bone resorption not only in women but also in men. Extraglandular aromatization of circulating androgen is the major source of estrogen in post-menopausal women and men. In order to assess the capacity of bone cel...

journal_title：Molecular and cellular endocrinology

authors： Shozu M,Simpson ER

更新日期：1998-04-30 00:00:00

abstract：:While vitamin D supplementation is common, the anabolic mechanisms that improve bone status are poorly understood. Under standard mineralising conditions including media ionised calcium of 1.1 mM, 1,25-dihydroxyvitamin D3 (1,25D) enhanced differentiation and mineral deposition by the mature osteoblast/pre-osteocyte ce...

journal_title：Molecular and cellular endocrinology

authors： Yang D,Turner AG,Wijenayaka AR,Anderson PH,Morris HA,Atkins GJ

更新日期：2015-09-05 00:00:00

abstract：:The human corticotropin-releasing factor receptor type 1 (hCRF-R1) functional transcript is mainly expressed in the anterior pituitary corticotrophs, a tissue usually not available for clinical investigation. Splice variants translated into defective isoforms of the receptor have been described in few peripheral tissu...

journal_title：Molecular and cellular endocrinology

authors： Ben Simon E,Besancon R,Benetollo C,Nicolino M,Saez JM,Li JY

更新日期：2003-01-31 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine involved in autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease. IL-6 is produced by infiltrating immune cells and by thyrocytes. In the latter cell type, secretion of IL-6 is stimulated notably by interleukin-1 (IL-1), thyroid-stimulating ...

journal_title：Molecular and cellular endocrinology

authors： Szabo-Fresnais N,Blondeau JP,Pomérance M

更新日期：2008-03-12 00:00:00

abstract：:Although estradiol bone contribution has been deeply studied, little is known about the action of estrone. We investigated the direct action of estrone on osteoblasts growth and differentiation, with focus on the biochemical mechanism displayed by the estrogen. Murine calvarial osteoblast cultures in vitro exposed to ...

journal_title：Molecular and cellular endocrinology

authors： Crescitelli MC,Rauschemberger MB,Cepeda S,Sandoval M,Massheimer VL

更新日期：2019-12-01 00:00:00

abstract：:A large part of germ cells die apoptotically during testicular development in rodents. In the present study, a wave of germ cell apoptosis was observed between days 10 and 30 of postnatal life by in situ 3'-end labeling and DNA fragmentation analysis. To explore the potential involvement of Bcl-2 family members in thi...

journal_title：Molecular and cellular endocrinology

authors： Yan W,Suominen J,Samson M,Jégou B,Toppari J

更新日期：2000-07-25 00:00:00

abstract：:17β-Hydroxysteroid dehydrogenases (HSD17B) catalyze the oxidation/reduction of 17β-hydroxy/keto group in position C17 in C18- and C19 steroids. Most HSD17Bs are also catalytically active with substrates other than steroids. A subset of these enzymes is able to process thioesters of carboxylic acids. This group of enzy...

journal_title：Molecular and cellular endocrinology

authors： Hiltunen JK,Kastaniotis AJ,Autio KJ,Jiang G,Chen Z,Glumoff T

更新日期：2019-06-01 00:00:00

abstract：:Primary cultures of ovine thyroid cells were induced to differentiate by addition of thyrotropin (TSH). This was demonstrated as an accumulation of 2 thyroid-specific proteins, thyroglobulin and thyroid peroxidase, using immunofluorescent staining methods and immunoprecipitation of biosynthetically labeled cultures. A...

journal_title：Molecular and cellular endocrinology

authors： Errick JE,Eggo MC,Burrow GN

更新日期：1985-11-01 00:00:00

abstract：:A thyroid-specific enhancer element located upstream from the bovine thyroglobulin gene had been shown to contain three contiguous regions that are protected by thyroid transcription factor 1 (TTF-1) in footprinting experiments in vitro. The functional relevance of the individual TTF-1 binding sites was investigated i...

journal_title：Molecular and cellular endocrinology

authors： Christophe-Hobertus C,Christophe D

更新日期：1999-03-25 00:00:00

abstract：:The expression of the gene coding for thyroperoxydase, the main enzyme involved in the synthesis of the thyroid hormones, is controlled by thyroid stimulating hormone. In vitro transcription assays performed on nuclei isolated from dog thyroid cells in primary culture showed that this control is at the transcription l...

journal_title：Molecular and cellular endocrinology

authors： Gerard CM,Lefort A,Libert F,Christophe D,Dumont JE,Vassart G

更新日期：1988-12-01 00:00:00

abstract：:Allatostatins, peptides with an YXFGL-amide C-terminus, cause a rapid and reversible inhibition of the sesquiterpenoid juvenile hormone III biosynthesis by cockroach corpora allata in vitro. Inhibition is relieved by farnesol and by mevalonate, and neither HMG-CoA reductase nor HMG-CoA synthesis (HMG-CoA synthase and ...

journal_title：Molecular and cellular endocrinology

authors： Sutherland TD,Feyereisen R

更新日期：1996-07-01 00:00:00

abstract：:The present study examines the involvement of cAMP in the transduction of the short-term effect of gonadotropin-releasing hormone (GnRH) on gonadotropin release in the teleost fish, tilapia. A 5 min pulse of dibutyryl cyclic AMP (dbcAMP; 0.03-3 mM) or forskolin (0.1-10 microM) resulted in dose-dependent surges in tila...

journal_title：Molecular and cellular endocrinology

authors： Levavi-Sivan B,Yaron Z

更新日期：1992-06-01 00:00:00

abstract：:Expression of insulin-like growth factor 1 (IGF-1) mRNAs splice forms was recently shown to be stimulated by myofibrillar proteins released from the damaged muscle. In this study, we report that individual subfragments of titin and myomesin composed of Fn type III and Ig-like domains can activate expression of two IGF...

journal_title：Molecular and cellular endocrinology

authors： Kravchenko IV,Furalyov VA,Chatziefthimiou S,Wilmanns M,Popov VO

更新日期：2015-01-05 00:00:00