Abstract:
:The endocrine function of the ovary is dependent upon the ovarian follicle, which on a cellular basis consists of an oocyte surrounded by adjacent somatic cells responsible for generating sex steroid hormones and maintenance of hormonal stasis with the hypothalamic-pituitary axis. As females age, both fertility and the endocrine function of the ovary decline due to waning follicle numbers as well as aging-related cellular dysfunction. Although there is currently no cure for ovarian failure and endocrine disruption, recent advances in ovarian biology centered on ovarian stem cell and progenitor cell populations have brought the prospects of cell- or tissue-based therapeutic strategies closer to fruition. Herein, we review the relative contributions of ovarian stem cells to ovarian function during the reproductive lifespan, and postulate steps toward the development of ovarian stem cell-based approaches to advance fertility treatments, and also importantly to provide a physiological long-term means of endocrine support.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Truman AM,Tilly JL,Woods DCdoi
10.1016/j.mce.2016.10.012subject
Has Abstractpub_date
2017-04-15 00:00:00pages
74-84eissn
0303-7207issn
1872-8057pii
S0303-7207(16)30420-8journal_volume
445pub_type
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