Abstract：
:Gonadotrophins are fundamental to the mechanisms regulating follicle status and development. Follicles in the ovary are either quiescent or committed to one of two pathways: growth or atresia. The requirement for gonadotrophins by the follicles varies with development: committed follicles grow independently of gonadotrophins (primarily FSH) until the late preantral stage when antrum formation is contingent upon FSH. The involvement of estrogen in regulating gonadotrophin secretion is well documented and while evidence for a local regulatory role of estrogen in the ovary mounts, an obligatory role for estrogen in the folliculogenic process has not been established. The availability of a wide range of gene-disrupted mice termed 'knockouts', is providing information relevant to the study of folliculogenesis. Mice deficient in either estrogen or estrogen receptors, are infertile primarily due to either a block in folliculogenesis prior to antrum formation or as a consequence of failing to ovulate. Blocking estrogen stimulated, post-receptor molecules such as cyclin D2, severely retards granulosa cell proliferation and leads to infertility, although the contribution of estrogen in this model is not so clear given that FSH also stimulates cyclin D2. Similar problems dissociating the roles of FSH and estrogen are evident with the FSH deficient animal models. Nevertheless, estrogen is clearly an important and probably obligatory regulator of folliculogenesis, especially in the post antral stage. The exact points in the folliculogenic process where estrogen exerts its principal effects remains to be elucidated.
journal_name
Mol Cell Endocrinoljournal_title
Molecular and cellular endocrinologyauthors
Drummond AE,Findlay JKdoi
10.1016/s0303-7207(99)00038-6keywords:
subject
Has Abstractpub_date
1999-05-25 00:00:00pages
57-64issue
1-2eissn
0303-7207issn
1872-8057pii
S0303-7207(99)00038-6journal_volume
151pub_type
杂志文章,评审abstract：:Inhibin A and B are dimeric proteins capable of suppressing FSH both in vitro and in vivo. The principal form in the male is inhibin B which is produced in the testis and circulates to inhibit pituitary FSH secretion. Activin A, B and AB are dimeric proteins that share the same beta subunits with the inhibins but, in ...
journal_title：Molecular and cellular endocrinology
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journal_title：Molecular and cellular endocrinology
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/0303-7207(90)90053-b
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journal_title：Molecular and cellular endocrinology
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journal_title：Molecular and cellular endocrinology
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journal_title：Molecular and cellular endocrinology
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更新日期：2019-09-15 00:00:00
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journal_title：Molecular and cellular endocrinology
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更新日期：2015-02-05 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
doi：10.1016/j.mce.2008.04.003
更新日期：2008-08-13 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章
doi：10.1016/0303-7207(82)90013-2
更新日期：1982-04-01 00:00:00
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journal_title：Molecular and cellular endocrinology
pub_type： 杂志文章,评审
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更新日期：1998-10-25 00:00:00
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更新日期：1986-04-01 00:00:00
