解剖学和形态学
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abstract::In the past years, enantioanalysis became very important for clinical analysis; biomarkers/substances of biomedical importance with chiral structure should be analyzed and their presence correlated with the specific disorder. Therefore, we developed a method for the assay of l- and d-glucose, based on molecular recogn...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22843
更新日期:2018-05-01 00:00:00
abstract::Supercritical fluid chromatography (SFC) is already used for enantioseparation in the pharmaceutical industry, but it is rarely used for the separation of chiral pesticides. Comparing with high performence liquid chromatography, SFC uses much more environmnetal friendly and economic mobile phase, supercritical CO2 . I...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22836
更新日期:2018-05-01 00:00:00
abstract::The enantiomeric resolution of DL-alanine-DL-tryptophan dipeptide is described on amylose stationary phase. The eluent used was CH3 OH─CH3 COONH4 (10mM)─CH3 CN (50: 40, 10) at 0.8-mL/min flow, 230-nm detection, 25-minute run time, and 25°C ± 1°C temperature. The chiral phase was amylose [AmyCoat RP (15 cm × 0.46 cm × ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22813
更新日期:2018-04-01 00:00:00
abstract::The two enantiomers of 2,2'-bioxirane were synthesized, and their chiroptical properties were thoroughly investigated in various solvents by polarimetry, vibrational circular dichroism (VCD), and Raman optical activity (ROA). Density functional theory (DFT) calculations at the B3LYP/aug-cc-pVTZ level revealed the pres...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22814
更新日期:2018-04-01 00:00:00
abstract::The special relationship between France and the polarization of light from the beginning of the 19th century until the present day is reviewed in the lives and works of Étienne Louis Malus, François Arago, Jean-Baptiste Biot, Augustin Fresnel, Louis Pasteur, Frédéric Wallerant, Aimé Cotton, Francis Perrin, and Alain A...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22818
更新日期:2018-04-01 00:00:00
abstract::Numbers of resolving factors were investigated to improve resolution of venlafaxine 1. An effective resolving agent, O,O'-di-p-toluoyl-(R, R)-tartaric acid 2, was screened using similar method of 'Dutch resolution' from tartaric acid derivatives. The resolution efficiency was up to 88.4%, when the ratio of rac-1 and 2...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22790
更新日期:2018-03-01 00:00:00
abstract::The present study describes a generic strategy using capillary electrophoretic (CE) method for chiral enantioseparation of anti-Alzheimer drugs, namely, donepezil (DON), rivastigmine (RIV), and antifungal drugs, namely, ketoconazole (KET), Itraconazole (ITR), fluconazole (FLU), and sertaconazole (SRT) in which these d...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22777
更新日期:2018-02-01 00:00:00
abstract::Three β-keto sulfoxides (1-3) were synthesized in enantiopure form and investigated by means of circular dichroism (CD) spectroscopy, both in electronic and vibrational range (ECD, VCD), in combination with quantum chemical calculations. For compound 2, the X-ray structure was available; thus, the ECD in the solid sta...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22773
更新日期:2018-01-01 00:00:00
abstract::The use of stereodynamic probes is becoming one of the leading strategies for the fast and effective determination of enantiomeric excess. Recently, we reported a series of novel molecular architectures based on a modified tris(2-pyridylmethyl)amine complex (TPMA), which are able to amplify the electronic CD, in the c...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22780
更新日期:2018-01-01 00:00:00
abstract::Separations of six dihydropyridine enantiomers on three commercially available cellulose-based chiral stationary phases (Chiralcel OD-RH, Chiralpak IB, and Chiralpak IC) were evaluated with high-performance liquid chromatography (HPLC). The best enantioseparation of the six chiral drugs was obtained with a Chiralpak I...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22690
更新日期:2017-03-01 00:00:00
abstract::High-performance liquid chromatography (HPLC) is a powerful method in the area of chiral separation. In this study, a method of HPLC using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral selector was developed for enantioseparation of nine indanone and tetralone derivatives. The separation was performed on a conventi...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22665
更新日期:2017-01-01 00:00:00
abstract::A simple, green, and direct three-component condensation of acetophenone, aromatic aldehydes with 3-oxo-N-phenylbutanamide (acetoacetanilide) to generate some novel (1S,6R)/(1R,6S)-2-oxo-N,4,6-triarylcyclohex-3-enecarboxamide derivatives was carried out over K2 CO3 (10 mol%) with high efficiency in water/ethanol as gr...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22653
更新日期:2016-11-01 00:00:00
abstract::In order to investigate the chiral benzedrine molecules corresponding to their different characteristics in biochemical systems, we studied their interaction with D3 R using the docking method, molecular dynamic simulation, and quantum chemistry. The obtained results indicate that the active residues for R-benzedrine ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22630
更新日期:2016-10-01 00:00:00
abstract::Novel enantiopure 1,2,4-trizole-3-thiones containing a benzensulfonamide moiety were synthesized via multistep reaction sequence starting with D-phenylalanine methyl ester and L-phenylalanine ethyl ester as a source of chirality. The chemical structures of all compounds were characterized by elemental analysis, UV, IR...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22607
更新日期:2016-06-01 00:00:00
abstract::Searching the 3D structural fragments of organic molecules is challenging because of structural differences between X-ray and theoretically calculated geometries and the conformational flexibility of substituents. The codification program called Conformational Code for Organic Molecules (CCOM) can be used to unambiguo...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22596
更新日期:2016-05-01 00:00:00
abstract::Three chiral derivatives of the alkaloid sparteine (bispidines), characterized by the 3,7-diazabicyclo[3.3.1]nonane moiety, were designed as efficient ligands in a number of enantioselective reactions due to their metal coordination properties. A full evaluation of the 3D properties of the compounds was carried out, a...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22586
更新日期:2016-04-01 00:00:00
abstract::A molecular docking study, using molecular mechanics calculations with AutoDock and semi-empirical PM3 calculations, was used to predict the enantiodiscrimination of heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TMβCD) and ketoconazole (KTZ) enantiomers. A Density Functional Theory (DFT) single-point calculation at the...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22554
更新日期:2016-03-01 00:00:00
abstract::In this review, the recently reported approaches for the preparation of cyclodextrin-functionalized capillary monolithic columns are highlighted, with few applications in chiral separations using capillary liquid chromatography (CLC) and capillary electrochromatography (CEC). Chirality 28:97-109, 2016. © 2015 Wiley Pe...
journal_title:Chirality
pub_type: 杂志文章,评审
doi:10.1002/chir.22550
更新日期:2016-02-01 00:00:00
abstract::A rapid and effective RP-UHPLC-DAD method for enantioseparation of three flavanones, i.e., flavanone, naringenin, and hesperetin, was developed and validated. Chromatographic separation of the analytes was performed using a Chiralpak AD-3R analytical column under reverse phase conditions with methanol as the mobile ph...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22559
更新日期:2016-02-01 00:00:00
abstract::Chiral pesticides are now receiving more and more attention in the food-making process. This experiment studied the enantioselective behavior of diclofop-methyl (DM) and its main metabolite, diclofop (DC), during the soy sauce brewing process. Two kinds of commonly used strains, Aspergillus oryzae and Saccharomyces ro...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22545
更新日期:2016-01-01 00:00:00
abstract::The optically active mixed-ligand fac(S)-tris(thiolato)rhodium(III) complexes, ΔL -fac(S)-[Rh(aet)2 (L-cys-N,S)](-) (aet = 2-aminoethanethiolate, L-cys = L-cysteinate) () and ΔLL -fac(S)-[Rh(aet)(L-cys-N,S)2 ](2-) were newly prepared by the equatorial preference of the carboxyl group in the coordinated L-cys ligand. T...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22546
更新日期:2016-01-01 00:00:00
abstract::We studied the interaction of poly-l-lysine (PLL) and poly-l-arginine (PLAG) with sodium dodecyl sulfate (SDS) surfactant and the interaction of poly-l-glutamic acid (PLGA) and poly-l-aspartic acid (PLAA) with tetradecyltrimethylammonium bromide (TTAB) surfactant using vibrational circular dichroism (VCD) spectroscopy...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22534
更新日期:2015-12-01 00:00:00
abstract::Vibrational circular dichroism spectra (VCD) in the mid-IR region and electronic circular dichroism (ECD) spectra for three carnitine derivatives in the form of hydrochloride salts were recorded in deuterated methanol solutions. Density Functional Theory calculations help one to understand the significance of the obse...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22532
更新日期:2015-12-01 00:00:00
abstract::In this research, 10 chiral pesticides in fruits and vegetables were simultaneously determined using chiral liquid chromatography triple quadrupole-linear ion trap hybrid mass spectrometry (LC-QqLIT). The QuEChERS method was applied for sample preparation, and an enhanced product ion (EPI) scan was used to acquire tan...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22531
更新日期:2015-12-01 00:00:00
abstract::Caffeic acid-derived polyethers are a class of natural products isolated from the root extracts of comfrey and bugloss, which are endowed with intriguing pharmacological properties as anticancer agents. The synthesis of new polyether derivatives is achieved through ring-opening polymerization of chiral 2,3-disubstitut...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22539
更新日期:2015-12-01 00:00:00
abstract::Chiral discrimination in a racemic mixture of dipalmitoylphosphatidylcholine (DPPC) is induced by a new selector at the water-air interface: L-DPPC is segregated in the condensed phase of a Langmuir monolayer upon interactions with an enantiopure amphiphilic compound. ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22508
更新日期:2015-11-01 00:00:00
abstract::A simple one-dimensional (13)C NMR method is presented to discriminate between stereoisomers of organic compounds with more than one chiral center. By means of this method it is possible to discriminate between all eight stereoisomers of α-tocopherol. To achieve this the chiral solvating agent (S)-(+)-1-(9-anthryl)-2,...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22535
更新日期:2015-11-01 00:00:00
abstract::The attempts of applying chiroptical spectroscopy to supramolecular chirality are reviewed with a focus on vibrational circular dichroism (VCD). Examples were taken from gels, solids, and monolayers formed by low-molecular mass weight chiral gelators. Particular attention was paid to a group of gelators with perfluoro...
journal_title:Chirality
pub_type: 杂志文章,评审
doi:10.1002/chir.22482
更新日期:2015-10-01 00:00:00
abstract::The stereolability of chiral Hoveyda-Grubbs II type ruthenium complexes bearing N-heterocyclic carbene (NHC) ligands with Syn-phenyl groups on the backbone and Syn- or Anti-oriented o-tolyl N-substituents was studied by resorting to dynamic high-performance liquid chromatography (D-HPLC). A complete chromatographic pi...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22487
更新日期:2015-10-01 00:00:00
abstract::Stereoselective high-performance liquid chromatographic separations of eight sterically constrained cyclic β-amino acid enantiomer pairs were carried out using the newly developed Cinchona alkaloid-based zwitterionic chiral stationary phases Chiralpak ZWIX(+) and ZWIX(-). The effects of the mobile phase composition, t...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22458
更新日期:2015-09-01 00:00:00
abstract::Cyclic triamides bearing amidino groups at the meta position of the phenyl rings were synthesized, and their conformational properties in the crystal and in solution were examined. Compound exists as a capsule-type dimer of the enantiomers with a bowl-shaped syn conformation in the crystal state. Compound exists mainl...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22476
更新日期:2015-08-01 00:00:00
abstract::Novel chiral diisopropyl spiro bis(isoxazoline) ligands, anti-i-Pr-SPRIX and syn-i-Pr-SPRIX, were designed and synthesized. Their catalytic utility, X-ray crystallographic analyses, and complexation studies demonstrated the structural features of tetraisopropyl spiro bis(isoxazoline) ligand, i-Pr-SPRIX, which is a pro...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22467
更新日期:2015-08-01 00:00:00
abstract::The application of helical poly[(S)-3-vinyl-2,2'-dihydroxy-1, 1'-binaphthyl] (L*) in the asymmetric borane reduction of prochiral ketones was studied. The results showed that L* had excellent catalytic activity as well as enantioselectivity, giving up to 96% yield and up to 99% enantiomeric excess (ee) of the correspo...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22459
更新日期:2015-07-01 00:00:00
abstract::Patterning of solid surfaces with functional organic molecules has been a convenient route to fabricate two-dimensional materials with programmed architecture and activities. One example is the chiral nanoporous networks that can be created via controlled self-assembly of star-shaped molecules under 2D confinement. In...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22437
更新日期:2015-07-01 00:00:00
abstract::Three aldohexoses, glucose, galactose, and mannose, and three aldopentoses, arabinose, xylose, and ribose, were derivatized with L-tryptophanamide (L-TrpNH2 ) under alkaline conditions. Using a basic mobile phase (pH 9.2), the three aldohexoses or the three aldopentoses were simultaneously enantioseparated, respective...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22456
更新日期:2015-07-01 00:00:00
abstract::Nine β-aminoketones were synthesized via Mannich reaction when benzaldehyde was condensed with some primary amines and acetophenone. The purified compounds were identified by using spectroscopic methods. The enantiomeric separation of these derivatives was carried out by high-performance liquid chromatography (HPLC) u...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22434
更新日期:2015-05-01 00:00:00
abstract::Efficient synthesis of several new atropisomeric amino alcohols having 1-phenyl-1H-pyrrole skeleton are reported. Steric arrangements of the products were confirmed by a single-crystal X-ray measurement. The consequences of the size of the N-substituents on enantioinduction were examined by employing the enantioselect...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22415
更新日期:2015-03-01 00:00:00
abstract::Synthesis and catalyst performance of 2,3- (types and ) and 2,8-disubstituted (type ) thiourea bifunctional organocatalysts was attempted. The synthesis of catalyst of type has, so far, not been realized, while catalysts of type , i.e., the 2,3-exo- and the 2-endo-3-exo-thiourea catalysts, were prepared in six steps s...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22386
更新日期:2015-01-01 00:00:00
abstract::C2 -symmetric N,N-bis(phosphinomethyl)amines were prepared by the thermal reaction of aromatic aldehydes with ammonia and hypophosphorus acid as previously described. Both enantiomers of C2 -symmetric N,N-bis(phosphinomethyl)amine were obtained in a high enantiomeric purity through the diastereomeric salt formation wi...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22391
更新日期:2015-01-01 00:00:00
abstract::The concentration sensitivity of a racemic drug (chlorpheniramine maleate) in chiral capillary electrophoresis with electrospray ionization – mass spectrometric detection was improved ~500-fold via stacking. Enantiomeric separation was achieved through the use of a neutral chiral pseudostationary phase (2-hydroxpropyl...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22257
更新日期:2014-11-01 00:00:00