Abstract:
:Synthesis and catalyst performance of 2,3- (types and ) and 2,8-disubstituted (type ) thiourea bifunctional organocatalysts was attempted. The synthesis of catalyst of type has, so far, not been realized, while catalysts of type , i.e., the 2,3-exo- and the 2-endo-3-exo-thiourea catalysts, were prepared in six steps starting from (+)-camphor. The catalysts of type were prepared from (+)-camphor in eight steps. All the potential catalysts as well as most of the intermediate products were carefully structurally characterized. The thiourea bifunctional organocatalysts were tested in a model reaction of Michael addition of dimethyl malonate to trans-β-nitrostyrene.
journal_name
Chiralityjournal_title
Chiralityauthors
Ričko S,Golobič A,Svete J,Stanovnik B,Grošelj Udoi
10.1002/chir.22386subject
Has Abstractpub_date
2015-01-01 00:00:00pages
39-52issue
1eissn
0899-0042issn
1520-636Xjournal_volume
27pub_type
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