Enantioselective and diastereoselective Michael addition of ketone/aldehyde to trans-nitroolefins catalyzed by a novel chiral pyrrolidine-thiourea.

Abstract:

:The direct Michael addition reaction of cyclohexanone/aliphatic aldehydes with nitroolefins, catalyzed by a novel chiral pyrrolidine-thiourea catalyst 1a, is described. The desired 1,4-adducts were obtained in moderate yields with enantioselectivities up to 99% ee and dr up to 99:1 of the syn product.

journal_name

Chirality

journal_title

Chirality

authors

Shen Z,Zhang Y,Jiao C,Li B,Ding J,Zhang Y

doi

10.1002/chir.20382

subject

Has Abstract

pub_date

2007-05-05 00:00:00

pages

307-12

issue

4

eissn

0899-0042

issn

1520-636X

journal_volume

19

pub_type

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