Abstract:
:Although the organocatalytic direct asymmetric Michael reactions of carbonyl compounds to nitroalkenes have been investigated intensely, the Michael reaction of the thioether-based donors remains a rather undeveloped field. This work concerns the asymmetric Michael addition of aryl sulfanyl-propan-2-one to nitroalkenes with benzoic acid as an additive, and chiral amine-thiourea as a bifunctional organocatalyst. The reactions provided the highly functionalized chiral adducts with excellent enantioselectivities (up to 96% ee) and good yields. Moreover, the further transformed products exhibited excellent diastereoselectivity.
journal_name
Chiralityjournal_title
Chiralityauthors
Jiang X,Zhang B,Zhang Y,Lin L,Yan W,Wang Rdoi
10.1002/chir.20689subject
Has Abstractpub_date
2010-07-01 00:00:00pages
625-34issue
7eissn
0899-0042issn
1520-636Xjournal_volume
22pub_type
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