Abstract:
:Many drugs contain a chiral centre, or such a centre is introduced during metabolism of the drug in man and in animals. If a single chiral centre is present, the drug will normally exist as a mixture of two enantiomers, of which one may have quite different pharmacologic and/or toxic effects than the other. Chiral drugs that are used in psychiatry, and some other pharmacologically related drugs are identified, and the implications of the presence of one or two chiral centres in these drugs are discussed. Differences in pharmacologic properties of drug and metabolite enantiomers are identified and discussed. Also reviewed are the properties of some drugs used in psychiatry that both are chiral and display geometric isomerism.
journal_name
Chiralityjournal_title
Chiralityauthors
Coutts RT,Baker GBdoi
10.1002/chir.530010204subject
Has Abstractpub_date
1989-01-01 00:00:00pages
99-120issue
2eissn
0899-0042issn
1520-636Xjournal_volume
1pub_type
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