Abstract:
:The binding of the title benzodiazepine enantiomers and its modulation by warfarin and bilirubin were studied by chromatography on human serum albumin (HSA) immobilized on Sepharose 4B, and also by a combination of ultrafiltration and circular dichroism (UF-CD) methods. In the absence of warfarin and bilirubin the binding of the benzodiazepine was not stereoselective. (S)-Benzodiazepine and (S)-warfarin mutually increased the binding of each other, while the binding of (R)-benzodiazepine was preferentially enhanced on HSA saturated with bilirubin.
journal_name
Chiralityjournal_title
Chiralityauthors
Fitos I,Visy J,Magyar A,Kajtár J,Simonyi Mdoi
10.1002/chir.530020307subject
Has Abstractpub_date
1990-01-01 00:00:00pages
161-6issue
3eissn
0899-0042issn
1520-636Xjournal_volume
2pub_type
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