Abstract:
:We report the preparative separation of rac-zopiclone using malic acid as the resolving agent. Furthermore, two different methods for the analytical determination of zopiclone enantiomers by HPLC on chiral stationary phases are described. The benzodiazepine receptor binding of the isolated enantiomers was investigated. Half-maximal inhibitory concentrations of (+)- and (-)-zopiclone were 21 or 1,130 nmol/liter, respectively, indicating a more than 50 times higher affinity of the (+)-enantiomer toward the receptor.
journal_name
Chiralityjournal_title
Chiralityauthors
Blaschke G,Hempel G,Müller WEdoi
10.1002/chir.530050605subject
Has Abstractpub_date
1993-01-01 00:00:00pages
419-21issue
6eissn
0899-0042issn
1520-636Xjournal_volume
5pub_type
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