Abstract:
:The chiral discrimination ability of two recently prepared chiral stationary phases (CSP 1 and CSP 2), based on a leucine derived chiral selector, was tested for the enantiomers of dihydropyrimidone (DHPM) derivatives and compared with the commercially available Hyun-leucine CSP 3 and classical Pirkle-leucine CSP 4. By combining all of these CSPs, the enantiomers of all DHPM derivatives used in this study can be properly resolved. Particularly good enantioresolutions were achieved for thioureide derivatives, such as Monastrol. The results presented show that sulfur-aromatic interactions are meritorious for these very good separations.
journal_name
Chiralityjournal_title
Chiralityauthors
Forjan DM,Gazić I,Vinković Vdoi
10.1002/chir.20396subject
Has Abstractpub_date
2007-06-01 00:00:00pages
446-52issue
6eissn
0899-0042issn
1520-636Xjournal_volume
19pub_type
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