Abstract:
:The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to successfully discovering and developing chiral drugs in the pharmaceutical industry. This has been due to the rapid increase over the past 10-15 years in potential drug candidates containing one or more asymmetric centers. Based on the experiences of one pharmaceutical company, a summary of the establishment of a Chiral Technology toolbox, including the implementation of known tools as well as the design, development, and implementation of new Chiral Technology tools, is provided.
journal_name
Chiralityjournal_title
Chiralityauthors
McConnell O,Bach A 2nd,Balibar C,Byrne N,Cai Y,Carter G,Chlenov M,Di L,Fan K,Goljer I,He Y,Herold D,Kagan M,Kerns E,Koehn F,Kraml C,Marathias V,Marquez B,McDonald L,Nogle L,Petucci C,Schlingmann G,Tawa G,Tisdoi
10.1002/chir.20399subject
Has Abstractpub_date
2007-09-01 00:00:00pages
658-82issue
9eissn
0899-0042issn
1520-636Xjournal_volume
19pub_type
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