Abstract:
:A series of 1,4-disubstituted piperazine derivatives with hypnotic activity were examined on three polysaccharide-based chiral stationary phases, namely, Chiracel OD, Chiracel OJ and Chiralpak AD. It was possible to resolve all the compounds on all the phases examined (1.13 = alpha = 3.54). Cellulose tris(4-methylbenzoate) (Chiracel OJ) exhibited remarkable differences in the selectivity of enantiomeric resolution as compared to cellulose tris(3, 5-dimethylphenylcarbamate)-Chiracel OD and amylose tris(3, 5-dimethylphenylcarbamate)-Chiralpak AD. The differences in selectivity towards particular homologs on these phases could be explained in terms of lipophilicity and steric factors. Copyright 1999 Wiley-Liss, Inc.
journal_name
Chiralityjournal_title
Chiralityauthors
Chilmonczyk Z,Ksycinska H,Mazgajska M,Aboul-Enein HYdoi
10.1002/(SICI)1520-636X(1999)11:10<790::AID-CHIR9>subject
Has Abstractpub_date
1999-01-01 00:00:00pages
790-4issue
10eissn
0899-0042issn
1520-636Xpii
10.1002/(SICI)1520-636X(1999)11:10<790::AID-CHIR9>journal_volume
11pub_type
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