Abstract:
:A new enantiomerically pure P-chiral phosphine, (S)-cyclohexylmethyl- (1-naphthyl)phosphine (1) was prepared by phosphine-borane methodology and used in a mechanistic study of the Mitsunobu reaction. Enantiomerically enriched (S)-cyclo- hexylmethyl(1-naphtyl)phosphine oxide (8) is obtained if the reaction proceeds through the phosphonium salt 4, whereas the intermediate dialkoxyphosphorane 5 leads to racemic phosphine oxide 8. The results of the experiments including the variation of the reaction conditions and the natures of alcohol and carboxylic acid used in the Mitsunobu reaction prove the competition of two alternative mechanisms (reaction via 4 or 5) on the second stage of the Mitsunobu reaction.
journal_name
Chiralityjournal_title
Chiralityauthors
Watanabe T,Gridnev ID,Imamoto Tdoi
10.1002/(SICI)1520-636X(2000)12:5/6<346::AID-CHIR8subject
Has Abstractpub_date
2000-06-01 00:00:00pages
346-51issue
5-6eissn
0899-0042issn
1520-636Xpii
10.1002/(SICI)1520-636X(2000)12:5/6<346::AID-CHIR8journal_volume
12pub_type
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