Abstract:
:The possibility that enantiodiscrimination of bilirubin might be involved in neuronal membrane destabilization, and therefore in bilirubin toxicity, was investigated, by circular dichroism, on model membranes composed of phospholipids. The equilibrium between bilirubin enantiomers is displaced at some extent by the interaction with certain phospholipids. The extent of equilibrium displacement depends on the molecular structure of phospholipids and on the state of charge of bilirubin. The results obtained validate the hypothesis of a possible involvement of chirality in bilirubin toxicity and support a previously suggested model for the molecular mechanism of the interaction of bilirubin with the synaptic membrane.
journal_name
Chiralityjournal_title
Chiralityauthors
Bernardini C,D'Arrigo P,Elemento G,Mancini G,Servi S,Sorrenti Adoi
10.1002/chir.20610subject
Has Abstractpub_date
2009-01-01 00:00:00pages
87-91issue
1eissn
0899-0042issn
1520-636Xjournal_volume
21pub_type
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