The possible role of enantiodiscrimination in bilirubin toxicity.

Abstract:

:The possibility that enantiodiscrimination of bilirubin might be involved in neuronal membrane destabilization, and therefore in bilirubin toxicity, was investigated, by circular dichroism, on model membranes composed of phospholipids. The equilibrium between bilirubin enantiomers is displaced at some extent by the interaction with certain phospholipids. The extent of equilibrium displacement depends on the molecular structure of phospholipids and on the state of charge of bilirubin. The results obtained validate the hypothesis of a possible involvement of chirality in bilirubin toxicity and support a previously suggested model for the molecular mechanism of the interaction of bilirubin with the synaptic membrane.

journal_name

Chirality

journal_title

Chirality

authors

Bernardini C,D'Arrigo P,Elemento G,Mancini G,Servi S,Sorrenti A

doi

10.1002/chir.20610

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

87-91

issue

1

eissn

0899-0042

issn

1520-636X

journal_volume

21

pub_type

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