Abstract:
:A series of silica-supported proline-based peptides were synthesized and applied as catalysts for direct asymmetric intermolecular aldol reactions. Among these, a peptide with two L-proline units was found to be the most efficient one for the asymmetric aldol reactions between acetone and aromatic aldehydes. The reactions generated the corresponding products with satisfactory isolated yields (up to 97%) and enantiomeric excesses (up to 96%) in the presence of this catalyst (5 mol %). Furthermore, the silica-supported organocatalyst could be recovered and recycled by a simple filtration of the reaction solution and used for five consecutive trials without loss of its reactivity.
journal_name
Chiralityjournal_title
Chiralityauthors
Yan J,Wang Ldoi
10.1002/chir.20603subject
Has Abstractpub_date
2009-04-01 00:00:00pages
413-20issue
4eissn
0899-0042issn
1520-636Xjournal_volume
21pub_type
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