Asymmetric aldol reactions catalyzed by efficient and recyclable silica-supported proline-based peptides.

Abstract:

:A series of silica-supported proline-based peptides were synthesized and applied as catalysts for direct asymmetric intermolecular aldol reactions. Among these, a peptide with two L-proline units was found to be the most efficient one for the asymmetric aldol reactions between acetone and aromatic aldehydes. The reactions generated the corresponding products with satisfactory isolated yields (up to 97%) and enantiomeric excesses (up to 96%) in the presence of this catalyst (5 mol %). Furthermore, the silica-supported organocatalyst could be recovered and recycled by a simple filtration of the reaction solution and used for five consecutive trials without loss of its reactivity.

journal_name

Chirality

journal_title

Chirality

authors

Yan J,Wang L

doi

10.1002/chir.20603

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

413-20

issue

4

eissn

0899-0042

issn

1520-636X

journal_volume

21

pub_type

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