Abstract:
:The five-steps synthesis of a hemicryptophane cage combining a benzene-1,3,5-tricarboxamide unit and a cyclotriveratrylene (CTV) moiety is described. Chiral high-performance liquid chromatography (HPLC) was used to resolve the racemic mixture. The absolute configuration of the isolated enantiomers was assigned by comparison of the experimental electronic circular dichroism (ECD) spectra with the calculated ones. X-ray molecular structures reveal that the capped benzene-1,3,5-tricarboxamide unit adopts a structurally chiral conformation in solid state: the chirality of CTV moiety controls the Λ or Δ orientation of the three amides.
journal_name
Chiralityjournal_title
Chiralityauthors
Long A,Jean M,Albalat M,Vanthuyne N,Giorgi M,Górecki M,Dutasta JP,Martinez Adoi
10.1002/chir.23131subject
Has Abstractpub_date
2019-11-01 00:00:00pages
910-916issue
11eissn
0899-0042issn
1520-636Xjournal_volume
31pub_type
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