Modulatory effect of chiral nonsteroidal anti-inflammatory drugs on apoptosis of human neutrophils.

abstract：:In the past years, enantioanalysis became very important for clinical analysis; biomarkers/substances of biomedical importance with chiral structure should be analyzed and their presence correlated with the specific disorder. Therefore, we developed a method for the assay of l- and d-glucose, based on molecular recogn...

journal_title：Chirality

authors： Stefan-van Staden RI,Mitrofan G

更新日期：2018-05-01 00:00:00

abstract：:To investigate the impacts of the widely used chiral herbicide fenoxaprop-ethyl (FE) on aquatic organisms, the enrichment, metabolism, acute toxicity, and oxidative stress of fenoxaprop-ethyl and its main metabolites fenoxaprop (FA), ethyl-2-(4-hydroxyphenoxy)propanoate (EHPP), 2-(4-hydroxyphenoxy)propanoic acid (HPPA...

journal_title：Chirality

authors： Xu Y,Jing X,Zhai W,Li X

更新日期：2020-07-01 00:00:00

abstract：:Experimental studies suggest that amide bond may significantly deviate from planar arrangement even in linear peptides and proteins. In order to find out the extent to which such deviation may influence principal amide spectroscopic properties, we conducted a computational study of nonplanar N-methylacetamide (NMA) co...

journal_title：Chirality

authors： Bednárová L,Malon P,Bour P

更新日期：2007-11-01 00:00:00

abstract：:A molecular docking study, using molecular mechanics calculations with AutoDock and semi-empirical PM3 calculations, was used to predict the enantiodiscrimination of heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TMβCD) and ketoconazole (KTZ) enantiomers. A Density Functional Theory (DFT) single-point calculation at the...

journal_title：Chirality

authors： Arsad SR,Maarof H,Wan Ibrahim WA,Aboul-Enein HY

更新日期：2016-03-01 00:00:00

abstract：:The objective of this brief highlight is to point out the central role of the exciton chirality method to gain insights on the structural basis of the recently achieved ligand gating of synthetic ion channels. This unprecedented ligand gating was achieved with an equally unprecedented transmembrane rigid-rod pi-stack ...

journal_title：Chirality

authors： Sakai N,Talukdar P,Matile S

更新日期：2006-02-01 00:00:00

abstract：:Stereoselectivity in the renal secretion of carbenicillin (CBPC) was studied in rabbits. Significant renal secretion of CBPC was observed in vivo, with the secretion of the S-epimer being greater than that of the R-epimer. Stereoselective transport of CBPC was further studied in vitro using basolateral and brush borde...

journal_title：Chirality

authors： Itoh T,Nakaura H,Koyano S,Tsuda Y,Yamada H

更新日期：1998-01-01 00:00:00

abstract：:Recent discovery of asymmetric desymmetrization of meso-heterocycles using (R,R)-(salen)manganese complex 2 as a catalyst allowed easy access to optically active 2,3,4-trisubstituted pyrrolidines. Taking advantage of this new reaction, we could achieve the short-step synthesis of (-)-swainsonine 1. ...

journal_title：Chirality

authors： Punniyamurthy T,Irie R,Katsuki T

更新日期：2000-06-01 00:00:00

abstract：:Three β-keto sulfoxides (1-3) were synthesized in enantiopure form and investigated by means of circular dichroism (CD) spectroscopy, both in electronic and vibrational range (ECD, VCD), in combination with quantum chemical calculations. For compound 2, the X-ray structure was available; thus, the ECD in the solid sta...

journal_title：Chirality

authors： Górecki M,Capozzi MAM,Albano G,Cardellicchio C,Di Bari L,Pescitelli G

更新日期：2018-01-01 00:00:00

abstract：:The direct asymmetric aldol reactions of equivalent molar amounts of aldehydes and ketones were carried out at -20 degrees C over alkaline Al(2)O(3) with 20 mol % of Pro-Trp as catalyst and 20 mol % of N-methylmorpholine or 1,4-diazabicyclo[2.2.2]octane as additive. After simple and environmentally friendly work-up, m...

journal_title：Chirality

authors： Lei M,Xia S,Wang J,Ge Z,Cheng T,Li R

更新日期：2010-06-01 00:00:00

abstract：:Two new chiral thiosemicarbazide ligands and their Cu (II), Ni (II), Pd (II), and Zn (II) complexes were synthesized and characterized by nuclear magnetic resonance (NMR) (only for ligand), Fourier transform infrared (FT-IR), ultraviolet visible (UV-Vis), mass, and elemental analysis. The antioxidant activity of ligan...

journal_title：Chirality

authors： Başaran E,Sıcak Y,Sogukomerogullari HG,Karaküçük-Iyidoğan A,Oruç-Emre EE,Sönmez M,Öztürk M

更新日期：2019-06-01 00:00:00

abstract：:The influence of endotoxin-induced inflammation on the enantioselective pharmacokinetics of propranolol, oxprenolol, and verapamil, which bind to alpha 1-acid glycoprotein, was studied in the rat. The racemic mixtures were given orally. In the control animals, for propranolol and oxprenolol, the plasma concentrations ...

journal_title：Chirality

authors： Laethem ME,Belpaire FM,Wijnant P,Rosseel MT,Bogaert MG

更新日期：1994-01-01 00:00:00

abstract：:The direct Michael addition reaction of cyclohexanone/aliphatic aldehydes with nitroolefins, catalyzed by a novel chiral pyrrolidine-thiourea catalyst 1a, is described. The desired 1,4-adducts were obtained in moderate yields with enantioselectivities up to 99% ee and dr up to 99:1 of the syn product. ...

journal_title：Chirality

authors： Shen Z,Zhang Y,Jiao C,Li B,Ding J,Zhang Y

更新日期：2007-05-05 00:00:00

abstract：:This work presents results of methyl 7-oxoabiet-13(14)-en-18-oate (3) self-oxidation with air-oxygen in the presence of various bases such as triethylamine or sodium t-butoxide. While under aerobic conditions, the use of sodium t-butoxide as a base results in the formation of four isomeric alcohols, an addition of tri...

journal_title：Chirality

authors： Masnyk M,Kuśmirek D,Trzybiński D,Frelek J

更新日期：2020-04-01 00:00:00

abstract：:A method for the determination of (R)- and (S)-atenolol in human plasma and urine is described. The enantiomers of atenolol are extracted into dichloromethane containing 3% heptafluorobutanol followed by acetylation with acetic anhydride at 60 degrees C for 2 h. The acetylated enantiomers were separated on a chiral al...

journal_title：Chirality

authors： Enquist M,Hermansson J

更新日期：1989-01-01 00:00:00

abstract：:In this review, the recently reported approaches for the preparation of cyclodextrin-functionalized capillary monolithic columns are highlighted, with few applications in chiral separations using capillary liquid chromatography (CLC) and capillary electrochromatography (CEC). Chirality 28:97-109, 2016. © 2015 Wiley Pe...

journal_title：Chirality

authors： Adly FG,Antwi NY,Ghanem A

更新日期：2016-02-01 00:00:00

abstract：:Reaction of (S)- or (R)-3-aminoquinuclidine with 2-chloropyrimidine or 2-bromopyrimidine led to an unexpected formation of both cis- and trans-octahydropyrrolo [2,3]pyridine derivatives. A single-step synthesis of two of the four stereoisomers of these octahydropyrrolo[2,3]pyridine derivatives provides a convenient wa...

journal_title：Chirality

authors： Goljer I,Molinari A,He Y,Nogle L,Sun W,Campbell B,McConnell O

更新日期：2009-07-01 00:00:00

abstract：:Parallel kinetic resolution of Evans' phenylglycine derived oxazolidinone using an equimolar combination of quasi-enantiomeric active esters (derived from [D,13C]-labeled 2-phenylpropionic acid) was achieved. The levels of stereocontrol were high, leading to products with predictable configurations. ...

journal_title：Chirality

authors： Coumbarides GS,Dingjan M,Eames J,Flinn A,Northen J

更新日期：2007-05-05 00:00:00

abstract：:Ropivacaine hydrochloride monohydrate (ropivacaine) is a new local anaesthetic agent which is administered exclusively as the (-)-(S)-form. The aim of the study was to determine whether metabolic racemisation of (-)-(S)-ropivacaine occurs. This was tested in man, rat, dog, and sheep after different routes of administr...

journal_title：Chirality

authors： Arvidsson T,Bruce HF,Halldin MM

更新日期：1995-01-01 00:00:00

abstract：:A selection of my work on chirality is sketched in two distinct parts of this lecture. Symmetry and Chirality explains how the discrete symmetries of parity P, time reversal T, and charge conjugation C may be used to characterize the properties of chiral systems. The concepts of true chirality (time-invariant enantiom...

journal_title：Chirality

authors： Barron LD

更新日期：2012-11-01 00:00:00

abstract：:Many drugs contain a chiral centre, or such a centre is introduced during metabolism of the drug in man and in animals. If a single chiral centre is present, the drug will normally exist as a mixture of two enantiomers, of which one may have quite different pharmacologic and/or toxic effects than the other. Chiral dru...

journal_title：Chirality

authors： Coutts RT,Baker GB

更新日期：1989-01-01 00:00:00

abstract：:Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Binding kinetics were followed by recording changes in the fluorescence of warfarin upon binding to HSA using the stopped...

journal_title：Chirality

authors： Fitos I,Visy J,Kardos J

更新日期：2002-05-15 00:00:00

abstract：:This work reports confirmation of the experimental assignment of the absolute-handedness chirality of single-walled carbon nanotubes (SWNTs). This was achieved by applying the scanning tunneling microscopy (STM) imaging technique to a supramolecular composite consisting of a metalized porphyrin derivative (nickel-5,15...

journal_title：Chirality

authors： Abd El-Mageed AIA,Ogawa T

更新日期：2020-03-01 00:00:00

abstract：:A detailed experimental investigation of an aza-Michael reaction of aniline and chalcone is presented. A series of Cinchona alkaloid-derived organocatalysts with different functional groups were prepared and used in the aza-Michael and retro-aza-Michael reaction. There was an interesting finding that a complete revers...

journal_title：Chirality

authors： Cai YF,Li L,Luo MX,Yang KF,Lai GQ,Jiang JX,Xu LW

更新日期：2011-05-01 00:00:00

abstract：:Compound A, a novel disubstituted pyrrolidine acid, is a member of a new class of agents that are potentially useful for the treatment of diabetes and dyslipidemia. The absolute configuration of this compound was determined by using vibrational circular dichroism (VCD). The results are in agreement with the assignment...

journal_title：Chirality

authors： Freedman TB,Cao X,Phillips LM,Cheng PT,Dalterio R,Shu YZ,Zhang H,Zhao N,Shukla RB,Tymiak A,Gozo SK,Nafie LA,Gougoutas JZ

更新日期：2006-09-01 00:00:00

abstract：:Trigonostemons G and H, two novel dimeric dinorditerpenoids, were isolated from the stem barks of Trigonostemon chinensis. Their planar structures and relative configurations were established by extensive analysis of spectroscopic data. Trigonostemons G and H possess a homodimeric biaryl skeleton obtained from two rea...

journal_title：Chirality

authors： Zhu Q,Tang C,Mándi A,Kurtán T,Ye Y

更新日期：2020-03-01 00:00:00

abstract：:Vibrational circular dichroism spectra (VCD) in the mid-IR region and electronic circular dichroism (ECD) spectra for three carnitine derivatives in the form of hydrochloride salts were recorded in deuterated methanol solutions. Density Functional Theory calculations help one to understand the significance of the obse...

journal_title：Chirality

authors： Mazzeo G,Abbate S,Longhi G,Castiglioni E,Villani C

更新日期：2015-12-01 00:00:00

abstract：:Human carboxylesterase 1 (hCES1) is an enzyme that plays an important role in hydrolysis of pharmaceuticals in the human liver. In this study, elucidation of the chiral recognition ability of hCES1 was attempted using indomethacin esters in which various chiral alcohols were introduced. Indomethacin was condensed with...

journal_title：Chirality

authors： Takahashi M,Takani D,Haba M,Hosokawa M

更新日期：2020-01-01 00:00:00

abstract：:Herein we report CD spectroscopic studies on complexes of (R,R)-dimethyl-, (R,R)-diisobutyl-, and (S,S)-di-sec-butyl-phenazino-18-crown-6 ligands (Scheme 1) with selected alkali (Na+, K+), alkaline earth (Mg2+, Ca2+), and transition-metal (Ag+, Zn2+, Ni2+, Cd2+, Pb2+) cations. The complexation was monitored in the 300...

journal_title：Chirality

authors： Szarvas S,Szalay L,Vass E,Hollósi M,Samu E,Huszthy P

更新日期：2005-06-01 00:00:00

abstract：:Four racemic esters of (1R*,7aR*)-3,6,7,7a-tetrahydro-1-hydroxy-7a-methyl-1H-inden-5(2H)-one were prepared and subjected to hydrolysis with two types of hydrolases, including alcalase and three lipases. Alcalase and lipase showed opposite enantiopreference on these esters. Based on this result, we developed a gram-sca...

journal_title：Chirality

authors： Lo LC,Chou TC,Shie JJ

更新日期：2004-05-05 00:00:00

abstract：:The chiral discrimination ability of two recently prepared chiral stationary phases (CSP 1 and CSP 2), based on a leucine derived chiral selector, was tested for the enantiomers of dihydropyrimidone (DHPM) derivatives and compared with the commercially available Hyun-leucine CSP 3 and classical Pirkle-leucine CSP 4. B...

journal_title：Chirality

authors： Forjan DM,Gazić I,Vinković V

更新日期：2007-06-01 00:00:00