From cosmic chirality to protein structure: Lord Kelvin's legacy.

abstract：:4-l-menthyloxycarbonyl 5-aryl prolinates were studied as organocatalysts of a novel three-component reaction of cyclohexanone, benzoic acid, and β-nitrostyrene. The presence of ortho-halogen atom in 5-aryl fragment of the catalyst is favored for driving the formation of chiral 7a-hydroxyoctahydro-2H-indol-2-one scaffo...

journal_title：Chirality

authors： Ivantcova PM,Kudryavtsev KV

更新日期：2020-06-01 00:00:00

abstract：:The present study describes a generic strategy using capillary electrophoretic (CE) method for chiral enantioseparation of anti-Alzheimer drugs, namely, donepezil (DON), rivastigmine (RIV), and antifungal drugs, namely, ketoconazole (KET), Itraconazole (ITR), fluconazole (FLU), and sertaconazole (SRT) in which these d...

journal_title：Chirality

authors： Abdel-Megied AM,Hanafi RS,Aboul-Enein HY

更新日期：2018-02-01 00:00:00

abstract：:Despite the fact that several studies have reported the concentrations of various free amino acids in tobacco, their enantiomeric composition is unknown. Both the absolute and enantiomeric compositions of proline, alanine, asparagine, aspartic acid, valine, methionine, leucine,and phenylalanine were determined for thr...

journal_title：Chirality

authors： Kullman JP,Chen X,Armstrong DW

更新日期：1999-01-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) are short-lived leukocytes that die by apoptosis. Although PMNs are crucial in the defense against infection, they have been implicated in the pathogenesis of tissue injury observed in inflammatory diseases. The induction or prevention of PMN apoptosis is currently discussed as a k...

journal_title：Chirality

authors： Zielińska-Przyjemska M,Główka FK,Klaczyńska J

更新日期：2008-02-01 00:00:00

abstract：:Ibuprofen was used to demonstrate that isolated rat hepatocytes offer a suitable in vitro model to investigate the metabolic chiral inversion of anti-inflammatory 2-arylpropionic acids (profens). The inversion of the pharmacologically inactive (-)-(R)-ibuprofen to the active (+)-(S)-ibuprofen was shown to obey apparen...

journal_title：Chirality

authors： Müller S,Mayer JM,Etter JC,Testa B

更新日期：1990-01-01 00:00:00

abstract：:The measurement of optical rotation (OR) and optical rotatory dispersion has been finding renewed interest for some years, because of advancement in computational methods and in the performance of new experiments. Here, we shortly review the traditional and most-used experimental methods. We define and discuss the two...

journal_title：Chirality

authors： Castiglioni E,Abbate S,Longhi G

更新日期：2011-10-01 00:00:00

abstract：:Reaction of (S)- or (R)-3-aminoquinuclidine with 2-chloropyrimidine or 2-bromopyrimidine led to an unexpected formation of both cis- and trans-octahydropyrrolo [2,3]pyridine derivatives. A single-step synthesis of two of the four stereoisomers of these octahydropyrrolo[2,3]pyridine derivatives provides a convenient wa...

journal_title：Chirality

authors： Goljer I,Molinari A,He Y,Nogle L,Sun W,Campbell B,McConnell O

更新日期：2009-07-01 00:00:00

abstract：:The two enantiomers of 2,2'-bioxirane were synthesized, and their chiroptical properties were thoroughly investigated in various solvents by polarimetry, vibrational circular dichroism (VCD), and Raman optical activity (ROA). Density functional theory (DFT) calculations at the B3LYP/aug-cc-pVTZ level revealed the pres...

journal_title：Chirality

authors： Daugey N,De Rycke N,Brotin T,Buffeteau T

更新日期：2018-04-01 00:00:00

abstract：:The five-steps synthesis of a hemicryptophane cage combining a benzene-1,3,5-tricarboxamide unit and a cyclotriveratrylene (CTV) moiety is described. Chiral high-performance liquid chromatography (HPLC) was used to resolve the racemic mixture. The absolute configuration of the isolated enantiomers was assigned by comp...

journal_title：Chirality

authors： Long A,Jean M,Albalat M,Vanthuyne N,Giorgi M,Górecki M,Dutasta JP,Martinez A

更新日期：2019-11-01 00:00:00

abstract：:The synthesis of the eight stereoisomers of muscarine has been efficiently accomplished by utilizing the two enantiomers of lactic esters as starting material. The synthetic strategy is based on a SnCl4-catalyzed addition of allyltrimethylsilane to O-protected lactic aldehydes followed by an iodocyclization process. A...

journal_title：Chirality

authors： De Amici M,Dallanoce C,De Micheli C,Grana E,Dondi G,Ladinsky H,Schiavi G,Zonta F

更新日期：1992-01-01 00:00:00

abstract：:A cyclic alpha-aminophosphonate was found to be a novel organocatalyst for Michael type addition reactions of carbonyl compounds to nitroolefins to afford the corresponding adducts in high enantio- and diastereoselectivities. ...

journal_title：Chirality

authors： Tao Q,Tang G,Lin K,Zhao YF

更新日期：2008-07-01 00:00:00

abstract：:Studies of xenobiotic disposition in rodents often employ experimental designs using differing routes of administration. In an effort to investigate the effects of route of administration on enantioselective disposition of xenobiotics, a chiral polychlorinated biphenyl (PCB), racemic PCB 136, was administered as a sin...

journal_title：Chirality

authors： Kania-Korwel I,Shaikh NS,Hornbuckle KC,Robertson LW,Lehmler HJ

更新日期：2007-01-01 00:00:00

abstract：:We have developed an improved circular dichroism (CD) and linear dichroism (LD) simultaneous measurement system for the vacuum ultraviolet (VUV) region by polarization modulation techniques using a four-period Onuki-type crossed undulator as a polarized light source. The system has been constructed at the VUV beamline...

journal_title：Chirality

authors： Tanaka M,Yagi-Watanabe K,Yamada T,Kaneko F,Nakagawa K

更新日期：2006-02-01 00:00:00

abstract：:In this work, a new capillary electrokinetic chromatography (EKC) approach using ethanediamine-bonded poly (glycidyl methacrylate) (Ami-PGMA) microspheres as pseudostationary phases (PSPs) for enantioseparation with a polysaccharide, chondroitin sulfate E (CSE), as the chiral selector. The CSE@Ami-PGMA EKC system was ...

journal_title：Chirality

authors： Sun X,Yu T,Xu G,Du Y,Chen J,Li X

更新日期：2019-02-01 00:00:00

abstract：:A new colorimetric chiral sensor material consisting of three different functional sites such as chromophore (2,4-dinitrophenylazophenol dye), binding site (crown ether), and chiral barrier (3,3'-diphenyl-1,1'-binaphthyl group) was prepared and applied to the recognition of the two enantiomers of primary amino alcohol...

journal_title：Chirality

authors： Cho EN,Li Y,Kim HJ,Hyun MH

更新日期：2011-04-01 00:00:00

abstract：:The present work firstly described the enantioseparation and determination of flumequine enantiomers in milk, yogurt, chicken, beef, egg, and honey samples by chiral liquid chromatography-tandem mass spectrometry. The enantioseparation was performed under reversed-phase conditions on a Chiralpak IC column at 20°C. The...

journal_title：Chirality

authors： Li S,Liu B,Xue M,Yu J,Guo X

更新日期：2019-11-01 00:00:00

abstract：:The interaction between the tetra-anionic porphyrin H2TPPS and its copper derivative, CuTPPS, with the tetra-cationic porphyrin H2T4 and its copper derivative, CuT4, leads, in aqueous solution, to the formation of remarkably stable and kinetically inert heteroaggregates. The aggregation process is under hierarchic con...

journal_title：Chirality

authors： Rosaria L,D'urso A,Mammana A,Purrello R

更新日期：2008-03-01 00:00:00

abstract：:A calculation of the circular dichroism (CD) spectra of carbonmonoxy- and deoxy-myoglobin is carried out in relation to a time-resolved CD experiment. This calculation allows us to assign a dominant role to the proximal histidine in the definition of the electronic normal modes and to interpret the transient CD struct...

journal_title：Chirality

authors： Dartigalongue T,Hache F

更新日期：2006-05-05 00:00:00

abstract：:Both novel enantiopure trans-1-aminobenz[f]indan-2-ols (4) were obtained from the racemate by the diastereomeric salt formation with (+)- and (-)-dibenzoyltartaric acids (8), respectively, and the absolute configuration of the enantiomer 4 in the less-soluble diastereomeric salt of racemic 4 with (+)-8 was determined ...

journal_title：Chirality

authors： Kobayashi Y,Kinbara K,Sato M,Saigo K

更新日期：2005-02-01 00:00:00

abstract：:Compared to simulated moving bed (SMB) chromatography, fractional crystallization is a simple and economical method for enantioseparation. Therefore, the coupling of SMB chromatography and fractional crystallization is suggested for enantioseparation of racemic compounds. In this work, a nonsteroidal antiinflammatory ...

journal_title：Chirality

authors： Hong Lu Y,Bun Ching C

更新日期：2004-10-01 00:00:00

abstract：:In order to get further insight into the mechanism by which bovine serum albumin (BSA) discriminates between enantiomers of organic acids, some radioisotopically labeled, nonaromatic carboxylic acids were studied under varying mobile phase conditions. It was found for a series of N-alkanoyl-DL-[3H]leucines that the D-...

journal_title：Chirality

authors： Allenmark S

更新日期：1993-01-01 00:00:00

abstract：:The electronic circular dichroism (ECD) spectra of two sesquiterpenoids (1 and 2) related to oplopanone, obtained from a methanolic extract of the plant Serphidium stenocephalum (Artemisia stenocephala), were measured and reproduced by means of time-dependent density functional theory (TDDFT) calculations, establishin...

journal_title：Chirality

authors： Shafiq N,Saleem M,Riaz N,Tousif MI,Jabbar A,Tareen RB,Pescitelli G

更新日期：2014-01-01 00:00:00

abstract：:A series of silica-supported proline-based peptides were synthesized and applied as catalysts for direct asymmetric intermolecular aldol reactions. Among these, a peptide with two L-proline units was found to be the most efficient one for the asymmetric aldol reactions between acetone and aromatic aldehydes. The react...

journal_title：Chirality

authors： Yan J,Wang L

更新日期：2009-04-01 00:00:00

abstract：:Several biologically active compounds structurally include the enantiopure 2-substituted-1,4-benzodioxane scaffold. The straightforward racemization that affects reactions involving most of the common chemical reactives is thus a crucial issue. The developing of a completely stereo-controlled synthetic route that does...

journal_title：Chirality

authors： Straniero V,Casiraghi A,Fumagalli L,Valoti E

更新日期：2018-07-01 00:00:00

abstract：:A variety of reactions can be categorized under the global concept of the "interconversion of stereoisomers." Thus, racemization or epimerization can result from inversion of labile chiral centers. From the examples available, some predictive rules are suggested for a chiral center of the type R"R'RC-H undergoing base...

journal_title：Chirality

authors： Testa B,Carrupt PA,Gal J

更新日期：1993-01-01 00:00:00

abstract：:N-formylphenylalanine was subjected to optical resolution using a chiral agent such as phenylethylamine enantiomer, (R)-phenylglycine methyl ester, (S)-N-benzyl-2-aminobutanol, alone or in a mixture with each other or in a mixture with benzylamine. ...

journal_title：Chirality

authors： Pálovics E,Fogassy E,Schindler J,Nógrádi M

更新日期：2007-01-01 00:00:00

abstract：:Chiral Eu3+ -based systems are frequently studied via circularly polarized luminescence spectroscopy. The emission lifetimes of each circular polarization, however, are virtually always ignored, because in a homogeneous sample of emitters, there should be no difference between the two. However, we show that in less ro...

journal_title：Chirality

authors： Hananel U,Schwartz G,Paiss G,Arrico L,Zinna F,Di Bari L,Cheshnovsky O,Markovich G

更新日期：2020-12-30 00:00:00

abstract：:Nine patients taking oral doses of 10 mg/12 h rac-pindolol as part of their treatment for hypertension in pregnancy were recruited for the study. Maternal and fetal gestational age ranged from 20-38 years and 28-41 weeks, respectively. Blood was collected from the umbilical cord vein and from the mother from zero to 1...

journal_title：Chirality

authors： Gonçalves PV,Matthes Ado C,Da Cunha SP,Lanchote VL

更新日期：2002-08-01 00:00:00

abstract：:The possibility that enantiodiscrimination of bilirubin might be involved in neuronal membrane destabilization, and therefore in bilirubin toxicity, was investigated, by circular dichroism, on model membranes composed of phospholipids. The equilibrium between bilirubin enantiomers is displaced at some extent by the in...

journal_title：Chirality

authors： Bernardini C,D'Arrigo P,Elemento G,Mancini G,Servi S,Sorrenti A

更新日期：2009-01-01 00:00:00

abstract：:The gem-disubstituted cyclotriphosphazene 1 reacted with piperazine (pip) to give the piperazine-bridged derivative 2, which is expected to exist in meso and racemic forms because the two PCl (pip) groups are stereogenic. The proton-decoupled (31)P NMR spectrum of 2 gave rise to two similar sets of ABX signals in a 1:...

journal_title：Chirality

authors： Bui TT,Coles SJ,Davies DB,Drake AF,Eaton RJ,Hursthouse MB,Kiliç A,Shaw RA,Yeşilot S

更新日期：2005-10-01 00:00:00