Stereoselective renal secretion of carbenicillin in rabbits: role of the organic anion transporter at the renal brush border membrane.

abstract：:The aim of this work was to establish structure-reactivity relationships between chiral aggregates (micelles, vesicles, and "pseudo-micelles" of amphiphilic dendrimers) and asymmetric induction. In water, micelles or vesicles formed with sugar-headed surfactants gave less than 10% ee in the reduction of prochiral keto...

journal_title：Chirality

authors： Rico-Lattes I I,Schmitzer A,Perez E,Lattes A

更新日期：2001-01-01 00:00:00

abstract：:The direct separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol, 1-(α-aminoalkyl)-2-naphthol, 2-(α-aminoarylmethyl)-1-naphthol analogs, and 2-(1-amino-2-methylpropyl)-1-naphthol) was performed on a newly developed chiral stationary phase containing isopropyl carbamate-cyclofructan6 as chiral selector, wit...

journal_title：Chirality

authors： Aranyi A,Ilisz I,Pataj Z,Szatmári I,Fülöp F,Armstrong DW,Péter A

更新日期：2011-08-01 00:00:00

abstract：:Diamino carboxylic acids have recently come to the attention of scientists working in the field of early life and its development. These are the monomers of a hypothetic early form of genetic material, the so-called Peptide Nucleic Acid (PNA) (Nielson et al., Proc Natl Acad Sci USA 2000;97:3868-3871). Since all biopol...

journal_title：Chirality

authors： Bredehöft JH,Breme K,Meierhenrich UJ,Hoffmann SV,Thiemann WH

更新日期：2007-07-01 00:00:00

abstract：:The present study describes the development of two approaches for the determination of the enantiopurity of both enantiomers of indatraline. Initially, a method was developed using different chiral solvating agents (CSAs) for diastereomeric discrimination regarding signal separation in (1)H nuclear magnetic resonance ...

journal_title：Chirality

authors： Grimm SH,Allmendinger L,Höfner G,Wanner KT

更新日期：2013-12-01 00:00:00

abstract：:This review tracks a decade of dynamic kinetic resolution developments with a biocatalytic inclination using enzymatic/microbial means for the resolution part followed by the racemization reactions either by means of enzymatic or chemocatalyst. These fast developments are due to the ability of the biocatalysts to sign...

journal_title：Chirality

authors： Kamaruddin AH,Uzir MH,Aboul-Enein HY,Halim HN

更新日期：2009-04-01 00:00:00

abstract：:In order to cope with the increasing number of publications on the separation of enantiomers by chromatography on a chiral stationary phase, the graphical molecular database CHIRBASE was created. In the present state, the database package covers information (structural, bibliographic, and chromatographic data) on liqu...

journal_title：Chirality

authors： Koppenhoefer B,Nothdurft A,Pierrot-Sanders J,Piras P,Popescu C,Roussel C,Stiebler M,Trettin U

更新日期：1993-01-01 00:00:00

abstract：:Previously, a diazaphospholidine has been synthesized and evaluated as a chiral derivatizing reagent for the determination of the optical purity of chiral alcohols via 31P NMR spectroscopy (Alexakis et al., J. Org. Chem. 57:1224-1237, 1992). Our laboratory is interested in the advantageous and practical applications o...

journal_title：Chirality

authors： House KL,O'Connor MJ,Silks LA 3rd,Dunlap RB,Odom JD

更新日期：1994-01-01 00:00:00

abstract：:Studies on the interactions between L-O- phosphoserine, as one of the simplest fragments of membrane components, and the Cinchona alkaloid cinchonine, in the crystalline state were performed. Cinchoninium L-O-phosposerine salt dihydrate (PhSerCin) crystallizes in a monoclinic crystal system, space group P2(1), with un...

journal_title：Chirality

authors： Wesełucha-Birczyńska A,Oleksyn BJ,Watroba J

更新日期：2010-06-01 00:00:00

abstract：:2-Alkenyl- and 2-vinyl-5-pyrimidyl alkanols are highly enantioselective asymmetric autocatalysts with significant amplification of enantiomeric excess in the enantioselective addition of diisopropylzinc to 2-alkenyl- and 2-vinylpyrimidine-5-carbaldehydes. Consecutive asymmetric autocatalysis starting from 7% ee increa...

journal_title：Chirality

authors： Sato I,Yanagi T,Soai K

更新日期：2002-02-01 00:00:00

abstract：:A new enantiomerically pure P-chiral phosphine, (S)-cyclohexylmethyl- (1-naphthyl)phosphine (1) was prepared by phosphine-borane methodology and used in a mechanistic study of the Mitsunobu reaction. Enantiomerically enriched (S)-cyclo- hexylmethyl(1-naphtyl)phosphine oxide (8) is obtained if the reaction proceeds thr...

journal_title：Chirality

authors： Watanabe T,Gridnev ID,Imamoto T

更新日期：2000-06-01 00:00:00

abstract：:Integrating spheres are widely used with UV-Vis and occasionally with infrared spectrophotometers to measure different types of samples, either in transmission mode (scattered transmission accessories) or in total/diffuse reflectance mode. We built a prototype sphere of the demountable type, which fits easily the samp...

journal_title：Chirality

authors： Castiglioni E,Albertini P

更新日期：2000-05-01 00:00:00

abstract：:Efficient synthesis of several new atropisomeric amino alcohols having 1-phenyl-1H-pyrrole skeleton are reported. Steric arrangements of the products were confirmed by a single-crystal X-ray measurement. The consequences of the size of the N-substituents on enantioinduction were examined by employing the enantioselect...

journal_title：Chirality

authors： Faigl F,Deák S,Erdélyi Z,Holczbauer T,Czugler M,Nyerges M,Mátravölgyi B

更新日期：2015-03-01 00:00:00

abstract：:Three chiral derivatives of the alkaloid sparteine (bispidines), characterized by the 3,7-diazabicyclo[3.3.1]nonane moiety, were designed as efficient ligands in a number of enantioselective reactions due to their metal coordination properties. A full evaluation of the 3D properties of the compounds was carried out, a...

journal_title：Chirality

authors： Castellano C,Sacchetti A,Meneghetti F

更新日期：2016-04-01 00:00:00

abstract：:Plasmonic nanoparticles (NPs) adsorbing onto helical bacteria can lead to formation of NP helicoids with micron scale pitch. Associated chiroptical effects can be utilized as bioanalytical tool for bacterial detection and better understanding of the spectral behavior of helical self-assembled structures with different...

journal_title：Chirality

authors： Feng W,Kadiyala U,Yan J,Wang Y,DiRita VJ,VanEpps JS,Kotov NA

更新日期：2020-07-01 00:00:00

abstract：:Both epimers of the naturally occurring nonproteinogenic amino acid L-cyclopentenylglycine, (2S,1'S)- and (2S, 1'R)-2-(cyclopent-2'-enyl)glycine, were obtained via a procedure involving condensation of 3-chlorocyclopentene with diethyl acetylaminomalonate, deethoxycarbonylation, chromatographic separation of the resul...

journal_title：Chirality

authors： Andersen L,Nielsen B,Jaroszewski JW

更新日期：2000-10-01 00:00:00

abstract：:An enantiocontrolled total synthesis of 19,20-dihydroakuammicine using a catalytic asymmetric Michael addition of dimethyl malonate to cyclohexenone as the key step is described. The above catalytic asymmetric Michael addition proceeds quite efficiently in the presence of a heterobimetalic asymmetric catalyst (ALB-KO-...

journal_title：Chirality

authors： Ohori K,Shimizu S,Ohshima T,Shibasaki M

更新日期：2000-06-01 00:00:00

abstract：:An enantioseparation of the antipsychotic drug butaclamol in human plasma by high-performance liquid chromatography (HPLC) with solid phase extraction is presented. The separation was achieved on the vancomycin macrocyclic antibiotic chiral stationary phase (CSP) Chirobiotic V with a polar ionic mobile phase (PIM) con...

journal_title：Chirality

authors： Aboul-Enein HY,Hefnawy MM

更新日期：2004-03-01 00:00:00

abstract：:The attempts of applying chiroptical spectroscopy to supramolecular chirality are reviewed with a focus on vibrational circular dichroism (VCD). Examples were taken from gels, solids, and monolayers formed by low-molecular mass weight chiral gelators. Particular attention was paid to a group of gelators with perfluoro...

journal_title：Chirality

authors： Sato H,Yajima T,Yamagishi A

更新日期：2015-10-01 00:00:00

abstract：:Despite that a number of experimental and theoretical investigations have been carried out to determine the structure of trialanine in water, the reported populations of polyproline II (PPII) and β-strand conformers vary and were found to be dependent on which spectroscopic method was used. Such discrepancies are due ...

journal_title：Chirality

authors： Oh KI,Lee KK,Park EK,Yoo DG,Hwang GS,Cho M

更新日期：2010-01-01 00:00:00

abstract：:Anodic oxidation of 1-acetoxy-3,4-dihydronaphthalene (1) and alpha-acetoxy-beta-alkylstyrenes (3) at -78 degrees C in a mixed solvent of acetonitrile (CH(3)CN), tetrahydrofuran (THF), and acetic acid (AcOH) containing (S)-tetraethylammonium camphorsulfonate as a chiral supporting electrolyte brought about enantioselec...

journal_title：Chirality

authors： Maekawa H,Itoh K,Goda S,Nishiguchi I

更新日期：2003-01-01 00:00:00

abstract：:The effects of temperature on the chiral recognition of cyclic β-amino acid enantiomers on zwitterionic [Chiralpak ZWIX(+) and ZWIX(-)] chiral stationary phases were investigated. Experiments were performed at different mobile phase compositions and under 10°C column temperature increments in the temperature range 10-...

journal_title：Chirality

authors： Ilisz I,Pataj Z,Gecse Z,Szakonyi Z,Fülöp F,Lindner W,Péter A

更新日期：2014-08-01 00:00:00

abstract：:Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the ...

journal_title：Chirality

authors： Liu CL,Wei CY,Wang SW,Peng YG

更新日期：2011-11-01 00:00:00

abstract：:The assignment of the absolute configuration of novel anti-inflammatory pyrrole derivatives has been accomplished by a combined strategy based on independent physical methods. The key step of our stereochemical characterization approach is the production at mg-scale of enantiomerically pure forms by HPLC on Chiralpak ...

journal_title：Chirality

authors： Biava M,Cirilli R,Fares V,Ferretti R,Gallinella B,La Torre F,Poce G,Porretta GC,Supino S,Villani C

更新日期：2008-06-01 00:00:00

abstract：:6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separated by supercritical fluid extraction using carbon dioxide. Diastereoisomeric salts were formed from the racemic base with less than one equivalent of O,O'-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification was achieved by part...

journal_title：Chirality

authors： Kmecz I,Simándi B,Bálint J,Székely E,Fogassy E,Kemény S

更新日期：2001-01-01 00:00:00

abstract：:The novel chiral spirobipyridopyrans 1 and 2 were synthesized by the acid catalyzed aldol type condensation of 5-deoxypyridoxal with the appropriate ketone and subsequent reaction of the resulting pyrylium salt with base. The indolinospiropyridopyrans 3-5, which contain the modified B(6) unit, were prepared by aldol r...

journal_title：Chirality

authors： Loncar-Tomaskovic L,Pustet N,Mrvos-Sermek D,Nagl A,Mintas M,Mannschreck A

更新日期：2001-02-01 00:00:00

abstract：:Novel enantiopure 1,2,4-trizole-3-thiones containing a benzensulfonamide moiety were synthesized via multistep reaction sequence starting with D-phenylalanine methyl ester and L-phenylalanine ethyl ester as a source of chirality. The chemical structures of all compounds were characterized by elemental analysis, UV, IR...

journal_title：Chirality

authors： Başaran E,Karaküçük-Iyidoğan A,Schols D,Oruç-Emre EE

更新日期：2016-06-01 00:00:00

abstract：:The enantioselective hydrogenation of C==N-C group containing compounds over modified metal catalysts is as yet an uninvestigated research area. This work contains results obtained on the hydrogenation of 1-pyrroline-2-carboxylate esters and sodium salt over cinchona alkaloid-modified alumina-supported Pd catalyst. Th...

journal_title：Chirality

authors： Szöllösi G,Kun I,Bartók M

更新日期：2001-01-01 00:00:00

abstract：:The UV absorption and electronic circular dichroism (ECD) spectra of (R)- and (S)-nicotine and (S)-nornicotine in aqueous solution were measured to a significantly lower wavelength range than previously reported, allowing the identification of four previously unobserved electronic transitions. The ECD spectra of the t...

journal_title：Chirality

authors： Clayton PM,Vas CA,Bui TT,Drake AF,McAdam K

更新日期：2013-05-01 00:00:00

abstract：:Gold particles covered with 1,1'-binaphthyl-2,2'-dithiol (BINAS) were prepared. Using size exclusion chromatography, it was possible for the first time to separate the sample into fractions with different sizes and colors. Transmission electron microscopy shows that the particles are very small, in the order of 1 nm o...

journal_title：Chirality

authors： Gautier C,Taras R,Gladiali S,Bürgi T

更新日期：2008-03-01 00:00:00

abstract：:Chiral molecules can either be handed (i.e., "shoes") or nonhanded ("potatoes"). The only chiral ligand partition for tetrahedral metal complexes (or for a tetrahedral carbon atom such as that found in amino acids and other chiral biological molecules) is the fully unsymmetrical degree 6 partition (1(4)), which leads ...

journal_title：Chirality

authors： King RB

更新日期：2001-08-01 00:00:00